Micro electric discharge milling is acquiring more importance in micro manufacturing because of its unique ability to produce three dimensional micro cavities with high aspect ratio in electrically conductive advanced materials regardless of its mechanical properties. The present study investigates the effects of major micro electric -discharge milling process variables (Voltage (V), Capacitance(C), electrode rotational speed (ERS) and feed rate (FR)) on Ti-6Al-4V. The output performance measures were identified as material removal rate (MRR) and tool wear rate (TWR) to assess the machinability of Ti-6AL-4V. Experiments were designed and carried out based on response surface methodology-Box Behnken statistical design. The most influencing parameters for responses (MRR, TWR) were found to be capacitance and feed rate. At a capacitance of 0.4 µF and feed rate of 18 mm/min, maximum MRR of 0.9756 mg/hr and TWR of 0.6342 mg/hr were observed. Similarly at 0.01 µF and 6mm/min, minimum MRR of 0.2308 mg/hr and TWR of 0.1259 mg/hr were obtained. Downloaded by [UNAM Ciudad Universitaria] at 20:25 25 December 2014 2