Micro flow rate particle beam interface for capillary liquid chromatography/mass spectrometry

Enantiomeric separation of chlorophenoxy acid herbicides by nano liquid chromatography‐UV detection on a vancomycin‐based chiral stationary phase

“…However, the main drawback of the nano-techniques is the relatively low injected volumes of samples, which can reduce the sensitivity. Other obvious advantages include the reduction of solvent due to the low flow rates employed, and the lower amount of sample required [14,15] The loss of sensitivity due to the small volumes injected can be avoided with on-column focusing techniques [16].…”

Peer Reviewed: Electron Ionization for LC/MS

“…The unavoidable long chain of interface mechanisms used to remove the solvent while saving the solute for ionization requires a compromise in performance: limits on sensitivity, range of linearity, tolerance for water in the mobile phase, and tolerance for nonvolatile, thermally sensitive compounds. The way to improve EI of an HPLC eluate is straightforward-reduce the flow rate (10). A few years ago, in collaboration with Waters, we developed a new LC/MS interface called capillary-EI (Cap-EI), which is based on a typical PB interface with a radically new nebulizer and simplified hardware (11).…”

Is particle beam an up-to-date LC-MS interface? State of the art and perspectives

“…Therefore, the generation of aerosols from a liquid input as low as 1 pLWmin requires specifically designed nebulizers. Some proposed techniques rely on ultrasonic or concentric nebulization (Richardson, Tarr, & Browner, 1993; Tarr, Zhu, & Browner, 1993), and, for the lowest flow-rates, on a modified pneumatic nebulization (Cappiello & Bruner, 1993). The validity of this approach has been widely demonstrated (Cappiello & Famiglini, 1994) and it involves, one after the other, all the aspects of the particle formation.…”