2009
DOI: 10.1002/smll.200801219
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Micro‐Nanostructured Protein Arrays: A Tool for Geometrically Controlled Ligand Presentation

Abstract: A novel approach for the rapid fabrication of extended areas of micrometer‐scaled patches of quasi‐hexagonally ordered gold nanoparticle arrays (see image) is presented. The resulting substrates serve as templates for the site‐specific immobilization of proteins to gold nanoparticles enabling nanoscopically and microscopically controlled protein deposition.

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Cited by 49 publications
(47 citation statements)
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“…By making use of the merits of topdown and bottom-up approaches, several combined patterning methods also have been recently reported. [23][24][25][26] The focus in this study is to produce patterns of low cost and high complexity (three or more addressable chemistries) over large areas. We present a straightforward and versatile method to create a long-range-ordered array of microscale "cups" with multiple material regions by a combination of CL and the bottom-up deposition techniques of plasma polymerization and evaporation as well as sputtering via physical vapor deposition (PVD).…”
Section: Doi: 101002/adma201100231mentioning
confidence: 99%
“…By making use of the merits of topdown and bottom-up approaches, several combined patterning methods also have been recently reported. [23][24][25][26] The focus in this study is to produce patterns of low cost and high complexity (three or more addressable chemistries) over large areas. We present a straightforward and versatile method to create a long-range-ordered array of microscale "cups" with multiple material regions by a combination of CL and the bottom-up deposition techniques of plasma polymerization and evaporation as well as sputtering via physical vapor deposition (PVD).…”
Section: Doi: 101002/adma201100231mentioning
confidence: 99%
“…Two-dimensional colloidal crystals have been attracting attention in science and technology as they have been applied in a variety of research fi elds including photonics, [ 1,2 ] nano-lithography, [ 3,4 ] and surface patterning, [ 5,6 ] plasmonics, [7][8][9][10] as well as sensing [11][12] or immobilization and positioning [ 13 ] of biologically relevant molecules. As assembly and deposition of classical, hexagonally ordered colloidal monolayers has matured into a widely used technology, the creation of increasingly complex colloidal arrangements can be identifi ed as an emerging challenge in colloidal crystallization.…”
Section: Introductionmentioning
confidence: 99%
“…[232] For several applications, the placement of such nanoparticles in a symmetric lattice is of crucial importance. As examples, platinum nanoparticles can then serve as etching masks to create highly ordered arrays of silicon nanopillars or nanoholes [121] while gold nanoparticle arrays have been used in plasmonics, [233] catalysis, [232] the generation of protein arrays [234] and to study cellsurface interactions. [16,235] Novel data storage devices might arise from the controlled placement of magnetic nanoparticles in symmetric arrays.…”
Section: Introductionmentioning
confidence: 99%