Microcup Arrays Featuring Multiple Chemical Regions Patterned with Nanoscale Precision

Ogaki, Ryosuke; Cole, Martin A.; Sutherland, Duncan S.; Kingshott, Peter

doi:10.1002/adma.201100231

Cited by 22 publications

(27 citation statements)

References 37 publications

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“…thiols on gold and silanes on oxide surfaces), where surfaces are fi rst patterned with different materials and sequentially incubated in different types of SAMs. Patterning of different materials can be carried out by, for example, photolithography [ 51 ] and CL [ 52 ] using physical vapor deposition (PVD) and/or chemical etching to make e.g. a stable chemical contrast or height variation.…”

Section: Chemical and Biomolecular Patterningmentioning

confidence: 99%

Guided Cellular Responses by Surface Cues for Nanomedicine Applications

Ogaki

Andersen

Foss

2016

Advances in Delivery Science and Technology

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Using surface cues to guide and ultimately control cellular responses is of paramount importance in numerous biomedical applications. Since cells react on feature sizes both on the micro and nanometer scale, these length scales are crucial parameters when designing new materials for applications in medicine e.g. for tissue engineering and drug delivery. Thus, variation of the features at the nanometer length scale is an integral part of nanomedicine research and development. In this chapter the interaction between biological systems and artifi cial materials will be addressed in general with focus on simplifi ed model systems where only one or a few parameters are varied at two-dimensional (2D) surfaces. At fi rst biomolecular adsorption/immobilization on surfaces will be addressed followed by a discussion of approaches to synthesize functionalized surfaces and the infl uence of such surfaces on cellular response. Some of the key parameters, which will be discussed in more detail, are topography, chemistry, and elastic modulus of the substrate. Even though there is a vast amount of published data it will become clear that there is still not a detailed understanding of the infl uence of these parameters on biosystems at the cellular level. Obviously, the degree of complexity increases when several of the surface cues are combined. The challenges in understanding the cellular responses in detail in real systems with the simultaneous variation of multiple parameters leads to the introduction of the fi eld of high throughput screening of biomaterials.

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Section: Chemical and Biomolecular Patterningmentioning

confidence: 99%

Guided Cellular Responses by Surface Cues for Nanomedicine Applications

Ogaki

Andersen

Foss

2016

Advances in Delivery Science and Technology

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“…Likewise, fragments with high negative loadings indicate that the fragments are present in higher concentrations in samples with high negative scores. On the heels of recent developments of SIMS instrumentations and applications of primary ions with higher secondary ion yields such as Bi þ , Bi 3 þ , C 60 þ , etc., static SIMS can provide chemical maps of biological or other complex materials in high spatial resolution [59][60][61][62][63][64]. The image resolution can be even higher in association with multivariate analysis methods (PCA and so on) to highlight the differences [65,66].…”

Section: Static Simsmentioning

confidence: 99%

“…The image resolution can be even higher in association with multivariate analysis methods (PCA and so on) to highlight the differences [65,66]. SIMS imaging is a powerful method to probe materials surface with complex chemistry, even chemical contrast can be verified in the sub-micrometre range [63,64]. For example, Ogaki et al [64] fabricated chemically complex and patterned substrates (Au-Polymer-Au-SiO 2 ) by combining different processes including particle self-assembling, plasma eching (optional), plasma polymerization, sputtering, evaporating, and finally ultrasonication.…”

Section: Static Simsmentioning

confidence: 99%

“…SIMS imaging is a powerful method to probe materials surface with complex chemistry, even chemical contrast can be verified in the sub-micrometre range [63,64]. For example, Ogaki et al [64] fabricated chemically complex and patterned substrates (Au-Polymer-Au-SiO 2 ) by combining different processes including particle self-assembling, plasma eching (optional), plasma polymerization, sputtering, evaporating, and finally ultrasonication. The Au and SiO 2 regions on the substrates are selectively functionalized with fluorinated thiol and chlorinated silane, respectively, to yield local specific signals (F À for Au and 35 Cl À / 37 Cl À for SiO 2 ).…”

Section: Static Simsmentioning

confidence: 99%

See 1 more Smart Citation

Characterization of biomaterials

Agrawal

Ong

Appleford

et al. 2013

Introduction to Biomaterials

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Characterization of Biomaterials will serve as a comprehensive resource for biomaterials researchers requiring detailed information on physical, chemical, mechanical, surface, in vitro or in vivo characterization. The book is designed for materials scientists, bioengineers, biologists, clinicians and biomedical device researchers seeking input towards planning on how to test their novel materials or structures or biomedical devices towards a specific application. Chapters are developed considering the need for both industrial researchers as well as academics"-Provided by publisher.

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“…The entire platform was chemically modified sequentially by immersing in solutions of 2‐methoxy (polyethyleneoxy) propyl‐trimethoxysilane (MPTS) and mixed thiols of biotinylated alkyl thiol (BAT) and methoxy‐terminated tri (ethylene glycol) undecane thiol (OEG). The sequential immersion of silanes followed by thiols enables MPTS and BAT/OEG to selectively assemble onto the SU‐8/Si regions and Au respectively, thus simultaneously rendering both the SU‐8 and silica nonfouling while allowing the Au regions to display biotin moieties (Figures S2 and S3, Supporting Information). Next, streptavidin was locally dispensed in individual SU‐8 wells containing chemical nanopatterns using an electronic multi‐pipette dispenser and incubated in a humid environment, and the entire wafer was washed with MilliQ water.…”

mentioning

confidence: 99%