Micro-particle manipulation by single beam acoustic tweezers based on hydrothermal PZT thick film

Zhu, Benpeng; Xu, Jiong; Liu, Ying; Xiong, Ke; Lee, Changyang; Yang, Xiaofei; Shiiba, Michihisa; Takeuchi, Shinichi; Zhou, Qifa; Shung, K. Kirk

doi:10.1063/1.4943492

Cited by 31 publications

(24 citation statements)

References 21 publications

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“…The most popular geometries of piezoelectric element used for the application of ultrasonic transducer are the concave shape, the focused ring configuration and the plane configuration . No matter which configuration is used, the ultrasound wave emitted by the piezoelectric element would converge or have the highest intensity at the focal point and then diverge along the propagation direction of ultrasound wave . To produce the vortex motion, the ultrasonic field has the following features: 1) the ultrasonic wave does not converge sharply at the center of the focus, 2) a hollow beam structure, and 3) the acoustic pressure at the center is as small as possible.…”

Section: Resultsmentioning

confidence: 99%

Helical‐Like 3D Ultrathin Piezoelectric Element for Complicated Ultrasonic Field

Chen

Qian

Lam

et al. 2019

Adv Funct Materials

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The developments of personalized medicine, ultrasound imaging, and contactless "microscopic handle" techniques are pushing ultrasonic transducers toward features of high frequency, device miniaturization, and even novel function. However, the conventional ultrasonic transducer has severely limited the development of novel ideas for applications due to its ordinary ultrasonic field. Although transducer arrays and monolithic acoustic holograms are capable of producing the complicated ultrasonic field, it is still difficult to achieve high frequency, device miniaturization, and novel function simultaneously. Here, a simple but effective approach is introduced that aims at reconstructing the complicated and high-frequency ultrasonic field via a compact single-element ultrasonic transducer. The 3D ultrathin piezoelectric element with a complex configuration is demonstrated theoretically and experimentally to produce the desired complicated ultrasonic field. With helical-like configuration, the single-element ultrasonic transducer offers efficient noncontact trapping and manipulation of suspended microparticles and biological cells. Moreover, its strong trapping capability leads to the 3D stacking of microparticles, which is a novel and interesting phenomenon achieved by a single-element ultrasonic transducer. This work brings the possibility of a complicated ultrasonic field for achieving novel high-frequency ultrasound applications through the design of smart structure ultrathin piezoelectric materials.

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Section: Resultsmentioning

confidence: 99%

Helical‐Like 3D Ultrathin Piezoelectric Element for Complicated Ultrasonic Field

Chen

Qian

Lam

et al. 2019

Adv Funct Materials

Self Cite

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“…This material is useful to increase the bandwidth of the ultrasonic devices [19]. However, large size material, which has high acoustic impedance, could increase the bandwidth, and lower the sensitivity of the ultrasonic devices, because the mechanical damping absorb the part of the acoustic powers [20,21]. In addition, proper acoustic matching layers of the ultrasonic devices are used to increase the bandwidth, but also lower the sensitivity of the ultrasonic devices [22].…”

Section: Introductionmentioning

confidence: 99%

Wide Bandwidth Class-S Power Amplifiers for Ultrasonic Devices

You

Choi

2020

Sensors

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Wide bandwidth ultrasonic devices are a necessity in high-resolution ultrasonic systems. Therefore, constant output voltages need to be produced across the wide bandwidths of a power amplifier. We present the first design of a wide bandwidth class-S power amplifier for ultrasonic devices. The −6 dB bandwidth of the developed class-S power amplifier was measured at 125.07% at 20 MHz, thus, offering a wide bandwidth for ultrasonic devices. Pulse-echo measurement is a performance measurement method used to evaluate the performance of ultrasonic transducers, components, or systems. The pulse-echo signals were obtained using an ultrasonic transducer with designed power amplifiers. In the pulse-echo measurements, time and frequency analyses were conducted to evaluate the bandwidth flatness of the power amplifiers. The frequency range of the ultrasonic transducer was measured and compared when using the developed class-S and commercial class-A power amplifiers with the same output voltages. The class-S power amplifiers had a relatively flat bandwidth (109.7 mV at 17 MHz, 112.0 mV at 20 MHz, and 109.5 mV at 23 MHz). When the commercial class-A power amplifier was evaluated under the same conditions, an uneven bandwidth was recorded (110.6 mV at 17 MHz, 111.5 mV at 20 MHz, and 85.0 mV at 23 MHz). Thus, we demonstrated that the designed class-S power amplifiers could prove useful for ultrasonic devices with a wide frequency range.

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“…Therefore, there is a need to manipulate the control parameters of the inducing sources to obtain suppression effects on the tumor cells. In contrast, high-frequency ultrasound has the potential to be focused onto targeted cells compared to low-frequency ultrasound [31][32][33][34]. However, the threshold conditions to stimulate tumor necrosis or cell suppression using additional photosensitizers with ultrasound are challenging to characterize in in vitro experiments because it is difficult to distinguish between intracellular and extracellular cavitation [35].…”

Section: Introductionmentioning

confidence: 99%

A Macro Lens-Based Optical System Design for Phototherapeutic Instrumentation

Choi

Choe

Ryu

2019

Sensors

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Light emitting diode (LED) and ultrasound have been powerful treatment stimuli for tumor cell growth due to non-radiation effects. This research is the first preliminary study of tumor cell suppression using a macro-lens-supported 460-nm LED combined with high-frequency ultrasound. The cell density, when exposed to the LED combined with ultrasound, was gradually reduced after 30 min of induction for up to three consecutive days when 48-W DC, 20-cycle, and 50 Vp-p sinusoidal pulses were applied to the LEDs through a designed macro lens and to the ultrasound transducer, respectively. Using a developed macro lens, the non-directional light beam emitted from the LED could be localized to a certain spot, likewise with ultrasound, to avoid additional undesirable thermal effects on the small sized tumor cells. In the experimental results, compared to LED-only induction (14.49 ± 2.73%) and ultrasound-only induction (13.27 ± 2.33%), LED combined with ultrasound induction exhibited the lowest cell density (6.25 ± 1.25%). Therefore, our measurement data demonstrated that a macro-lens-supported 460-nm LED combined with an ultrasound transducer could possibly suppress early stage tumor cells effectively.

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Micro-particle manipulation by single beam acoustic tweezers based on hydrothermal PZT thick film

Cited by 31 publications

References 21 publications

Helical‐Like 3D Ultrathin Piezoelectric Element for Complicated Ultrasonic Field

Helical‐Like 3D Ultrathin Piezoelectric Element for Complicated Ultrasonic Field

Wide Bandwidth Class-S Power Amplifiers for Ultrasonic Devices

A Macro Lens-Based Optical System Design for Phototherapeutic Instrumentation

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