Micro RNA, circular RNA, neutrophils, and myeloperoxydases in autoimmune diseases

Kéchida, M.; Daadaa, S.

doi:10.1016/b978-0-12-822564-6.00012-4

Cited by 1 publication

(2 citation statements)

References 134 publications

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“…The different inflammatory cytokines released that further facilitate the formation of autoantibodies interact with miRNA networks and consequently contribute to the pathogenesis of various autoimmune diseases 8 . In recent studies, it has been found that circular RNAs (circRNAs), a class of noncoding RNA, have high stability and evolutionarily conserved properties 124 . They are passive carriers of genetic expression and can affect auto‐antibody pathogenesis and formation.…”

Section: Role Of Mirna On Epigenetic Network Underlying Ad Progressionmentioning

confidence: 99%

“…8 In recent studies, it has been found that circular RNAs (circRNAs), a class of noncoding RNA, have high stability and evolutionarily conserved properties. 124 They are passive carriers of genetic expression and can affect auto-antibody pathogenesis and formation. They act as noninvasive biomarkers and consequently act along with miRNA for its upregulation and downregulation.…”

Section: Role Of Mirna On Epigenetic Network Underlying Ad Progressionmentioning

confidence: 99%

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Exploring the theranostic potentials of miRNA and epigenetic networks in autoimmune diseases: A comprehensive review

Nag,

Mitra,

Tripathi

et al. 2023

Immunity Inflam & Disease

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BackgroundAutoimmune diseases (AD) are severe pathophysiological ailments that are stimulated by an exaggerated immunogenic response towards self‐antigens, which can cause systemic or site‐specific organ damage. An array of complex genetic and epigenetic facets majorly contributes to the progression of AD, thus providing significant insight into the regulatory mechanism of microRNA (miRNA). miRNAs are short, non‐coding RNAs that have been identified as essential contributors to the post‐transcriptional regulation of host genome expression and as crucial regulators of a myriad of biological processes such as immune homeostasis, T helper cell differentiation, central and peripheral tolerance, and immune cell development.AimsThis article tends to deliberate and conceptualize the brief pathogenesis and pertinent epigenetic regulatory mechanism as well as miRNA networks majorly affecting five different ADs namely rheumatoid arthritis (RA), type 1 diabetes, multiple sclerosis (MS), systemic lupus erythematosus (SLE) and inflammatory bowel disorder (IBD) thereby providing novel miRNA‐based theranostic interventions.Results & DiscussionPertaining to the differential expression of miRNA attributed in target tissues and cellular bodies of innate and adaptive immunity, a paradigm of scientific expeditions suggests an optimistic correlation between immunogenic dysfunction and miRNA alterations.ConclusionTherefore, it is not astonishing that dysregulations in miRNA expression patterns are now recognized in a wide spectrum of disorders, establishing themselves as potential biomarkers and therapeutic targets. Owing to its theranostic potencies, miRNA targets have been widely utilized in the development of biosensors and other therapeutic molecules originating from the same.

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Section: Role Of Mirna On Epigenetic Network Underlying Ad Progressionmentioning

confidence: 99%

Section: Role Of Mirna On Epigenetic Network Underlying Ad Progressionmentioning

confidence: 99%

Exploring the theranostic potentials of miRNA and epigenetic networks in autoimmune diseases: A comprehensive review

Nag,

Mitra,

Tripathi

et al. 2023

Immunity Inflam & Disease

View full text Add to dashboard Cite

show abstract

Micro RNA, circular RNA, neutrophils, and myeloperoxydases in autoimmune diseases

Cited by 1 publication

References 134 publications

Exploring the theranostic potentials of miRNA and epigenetic networks in autoimmune diseases: A comprehensive review

Exploring the theranostic potentials of miRNA and epigenetic networks in autoimmune diseases: A comprehensive review

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