Micro‐RNAs as critical regulators of matrix metalloproteinases in cancer

Noruzi, Somaye; Azizian, Mitra; Mohammadi, Rezvan Sadr; Hosseini, Seyede Atefe; Rashidi, Bahman; Mohamadi, Yousef; Nesaei, Abolfazl; Seiri, Parvaneh; Sahebkar, Amirhossein; Salarinia, Reza; Aghdam, Arad Mobasher; Mirzaei, Hamed

doi:10.1002/jcb.27182

Cited by 30 publications

(46 citation statements)

References 210 publications

(303 reference statements)

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“…43 MiRNAs is a class of noncoding RNAs that act as epigenetic modulators. [44][45][46][47][48][49][50][51] These molecules via affecting a wide range of cellular and molecular targets exert their regulatory effects. [52][53][54][55][56][57][58] It has been showed that deregulation of this molecules are associated with initiation and progression of various diseases and pathological conditions.…”

Section: Curcumin and Retinal Diseases Therapymentioning

confidence: 99%

Curcumin: A new candidate for retinal disease therapy?

Farajipour

Rahimian

Taghizadeh

2018

J of Cellular Biochemistry

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The retina is the neural portion and light‐sensitive layer of the eye, which has been observed in most of the vertebrates. The retina is composed of light‐sensitive cells that absorb light and convert it into neural signals. These signals are sent to the brain for visual recognition. It has been shown that many pathogenesis conditions, including inﬂammation, angiogenesis, oxidative stress, and imbalanced histone modiﬁcations in the retina are associated with initiation and progression of retinal diseases (ie, glaucoma, diabetic retinopathy, and age‐related macular degeneration). Currently available treatments include laser surgery, freezing, stem‐cell therapy, shrinking abnormal blood vessels. It has some limitations, such as invasive methods, high costs, and many side effects. Hence, finding a new therapeutic platform for stopping or slowing of the disease progression is required. Curcumin is a natural product, which is associated with a wide range of properties, such as antioxidant, anti‐inflammatory, antiangiogenic, and antitumor activates. It exerts therapeutic effects via activation/inhibition cellular and molecular targets involved in various diseases, such as retinal diseases. Increasing evidence revealed that curcumin can be used as a therapeutic option in the treatment of different retinal diseases. Here, we summarized various clinical and preclinical studies that used curcumin as a therapeutic agent in the treatment of retinal disorders.

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Section: Curcumin and Retinal Diseases Therapymentioning

confidence: 99%

Curcumin: A new candidate for retinal disease therapy?

Farajipour

Rahimian

Taghizadeh

2018

J of Cellular Biochemistry

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“…MicroRNAs are small non‐coding RNAs which act as epigenetic regulators . These molecules play critical roles in regulation of gene expression in the RNA and protein levels .…”

Section: Microrna and Exosome‐based Vaccinementioning

confidence: 99%

“…96 9 | MICRORNA AND EXOSOME-BASED VACCINE MicroRNAs are small non-coding RNAs which act as epigenetic regulators. [99][100][101][102][103][104][105][106] These molecules play critical roles in regulation of gene expression in the RNA and protein levels. 22,[107][108][109][110][111][112][113] It has been shown that deregulation of microRNAs is associated with initiation and progression of various diseases such as infectious diseases, cardiovascular diseases, diabetes, neurogenerative diseases, and cancer.…”

Section: Influenza Rna Vaccinementioning

confidence: 99%

Influenza vaccine: Where are we and where do we go?

Keshavarz

Mirzaei

Salemi

et al. 2018

Reviews in Medical Virology

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Summary The alarming rise of morbidity and mortality caused by influenza pandemics and epidemics has drawn attention worldwide since the last few decades. This life‐threatening problem necessitates the development of a safe and effective vaccine to protect against incoming pandemics. The currently available flu vaccines rely on inactivated viral particles, M2e‐based vaccine, live attenuated influenza vaccine (LAIV) and virus like particle (VLP). While inactivated vaccines can only induce systemic humoral responses, LAIV and VLP vaccines stimulate both humoral and cellular immune responses. Yet, these vaccines have limited protection against newly emerging viral strains. These strains, however, can be targeted by universal vaccines consisting of conserved viral proteins such as M2e and capable of inducing cross‐reactive immune response. The lack of viral genome in VLP and M2e‐based vaccines addresses safety concern associated with existing attenuated vaccines. With the emergence of new recombinant viral strains each year, additional effort towards developing improved universal vaccine is warranted. Besides various types of vaccines, microRNA and exosome‐based vaccines have been emerged as new types of influenza vaccines which are associated with new and effective properties. Hence, development of a new generation of vaccines could contribute to better treatment of influenza.

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“…6 | MicroRNA AND PANCREATIC β CELLS: PHYSIOLOGICAL AND PATHOLOGICAL ASPECTS miRNAs are a group of noncoding RNAs which plays a crucial role in epigenetic procedures (Fathullahzadeh, Mirzaei, Honardoost, Sahebkar, & Salehi, 2016;Golabchi et al, 2018;Mashreghi et al, 2018;Mirzaei, Khataminfar, et al, 2016;Mirzaei, Naseri, et al, 2016;Mirzaei, Sahebkar, Jaafari, Goodarzi, & Mirzaei, 2017;Saadatpour et al, 2016;Salarinia et al, 2016). These structures exert their effects by means of affecting on some cellular and molecular pathways Jamali et al, 2018;Noruzi et al, 2018).…”

Section: Oxidative Stress and T2dmentioning

confidence: 99%

Molecular aspects of pancreatic β‐cell dysfunction: Oxidative stress, microRNA, and long noncoding RNA

Borujeni

Esfandiary

Baradaran

et al. 2018

Journal Cellular Physiology

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Metabolic syndrome is known as a frequent precursor of type 2 diabetes mellitus (T2D). This disease could affect 8% of the people worldwide. Given that pancreatic β‐cell dysfunction and loss have central roles in the initiation and progression of the disease, the understanding of cellular and molecular pathways associated with pancreatic β‐cell dysfunction can provide more information about the underlying pathways involved in T2D. Multiple lines evidence indicated that oxidative stress, microRNA, and long noncoding RNA play significant roles in various steps of diseases. Oxidative stress is one of the important factors involved in T2D pathogenesis. This could affect the function and survival of the β cell via activation or inhibition of several processes and targets, such as receptor‐signal transduction, enzyme activity, gene expression, ion channel transport, and apoptosis. Besides oxidative stress, microRNAs and noncoding RNAs have emerged as epigenetic regulators that could affect pancreatic β‐cell dysfunction. These molecules exert their effects via targeting a variety of cellular and molecular pathways involved in T2D pathogenesis. Here, we summarized the molecular aspects of pancreatic β‐cell dysfunction. Moreover, we highlighted the roles of oxidative stress, microRNAs, and noncoding RNAs in pancreatic β‐cell dysfunction.

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Micro‐RNAs as critical regulators of matrix metalloproteinases in cancer

Cited by 30 publications

References 210 publications

Curcumin: A new candidate for retinal disease therapy?

Curcumin: A new candidate for retinal disease therapy?

Influenza vaccine: Where are we and where do we go?

Molecular aspects of pancreatic β‐cell dysfunction: Oxidative stress, microRNA, and long noncoding RNA

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