micro<scp>RNA</scp> level is raised in the hair shafts of patients with dematomyositis in comparison with normal subjects and patients with scleroderma

Inoue, Mayuri; Jinnin, Masatoshi; Wang, Zhongzhi; Nakamura, Kayo; Inoue, Kuniko; Ichihara, Asako; Moriya, Chikako; Sakai, Keisuke; Fukushima, Satoshi; Ihn, Hironobu

doi:10.1111/ijd.12958

Cited by 3 publications

(4 citation statements)

References 19 publications

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“…40 We next determined miR-214-3p levels in the hair, because miR-214-3p is a unique miRNA that is detected in the skin but not in serum. 41 Hair root and hair shafts were obtained from nine dermatomyositis patients, 18 scleroderma patients and 15 normal subjects. There were no significant differences in hair root miR-214-3p levels among normal subject, scleroderma patients and dermatomyositis patients.…”

Section: Polymyositis/dermatomyositismentioning

confidence: 99%

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Recent progress in studies of miRNA and skin diseases

Jinnin

2015

The Journal of Dermatology

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miRNA is a family of small non-coding RNA that consists of 22 nucleotides on average. miRNA are implicated in various cellular activities such as cell proliferation or migration via the modulation of gene expression, and also are linked to the pathogenesis of human diseases. This paper reviews recent research progress about the contribution of miRNA to the pathogenesis of various skin diseases, and possible application of miRNA as the disease markers in each disease. For example, downregulated miR-424-5p in psoriatic skin causes the overexpression of MEK1 and cyclin E1 in psoriatic keratinocytes, resulting in the keratinocyte overgrowth and hyperproliferation seen in the disease. Although there was no significant difference in the serum miR-424-5p levels between psoriasis patients and healthy controls, serum miR-1266-5p levels were significantly upregulated in psoriasis patients, and showed weak and inverse correlation with disease activity. Furthermore, combination of serum levels of miR-146a-5p and -203a-3p was more reliable to distinguish psoriasis patients and normal subjects, than each miRNA alone. Hair shaft miR-424-5p levels were significantly higher in psoriasis patients than normal subjects, while hair root miR-19a-3p levels in psoriasis patients were inversely correlated with the duration between symptom onset and the first visit to the hospital. Future researches of miRNA will enable the advances of their clinical applications including the clarification of pathogenesis, disease markers and novel treatments.

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Section: Polymyositis/dermatomyositismentioning

confidence: 99%

“…We next determined miR‐214‐3p levels in the hair, because miR‐214‐3p is a unique miRNA that is detected in the skin but not in serum . Hair root and hair shafts were obtained from nine dermatomyositis patients, 18 scleroderma patients and 15 normal subjects.…”

Section: Polymyositis/dermatomyositismentioning

confidence: 99%

Recent progress in studies of miRNA and skin diseases

Jinnin

2015

The Journal of Dermatology

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“…The stability of miRNAs in serum and plasma makes them an easy and feasible biomarker to investigate in diagnostic applications. Their differential expression in serum or plasma compared to that in a tissue sample was of extreme importance to better understand the specific processes associated with the pathophysiological condition [ 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ]. By comparing the serum expression of selected miRNAs in s-IBM patients with respect to healthy patients, we found that hsa-miR-192-5p was significantly downregulated in the serum of s-IBM patients compared to that of the control group, while hsa-miR-372-3p was significatively upregulated.…”

Section: Discussionmentioning

confidence: 99%

“…The miRNAs expression profile of IIMs patients has been investigated in muscles, skin, and hair shaft biopsies [ 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 ]. Circulating miRNAs has been less frequently explored in IIMs, mainly in dermatomyositis and polymyositis, with only one study evaluating whole blood miRNAs expression in s-IBM patients [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Serum-Circulating microRNAs in Sporadic Inclusion Body Myositis

Lucchini

Arcangelis

Santoro

et al. 2023

IJMS

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Background: Sporadic inclusion body myositis (s-IBM) represents a unique disease within idiopathic inflammatory myopathies with a dual myodegenerative–autoimmune physiopathology and a lack of an efficacious treatment. Circulating miRNA expression could expand our knowledge of s-IBM patho-mechanisms and provide new potential disease biomarkers. To evaluate the expression of selected pre-amplified miRNAs in the serum of s-IBM patients compared to those of a sex- and age-matched healthy control group, we enrolled 14 consecutive s-IBM patients and 8 sex- and age-matched healthy controls. By using two different normalization approaches, we found one downregulated and three upregulated miRNAs. hsa-miR-192-5p was significantly downregulated, while hsa-miR-372-3p was found to be upregulated more in the s-IBM patients compared to the level of the controls. The other two miRNAs had a very low expression levels (raw Ct data > 29). hsa-miR-192-5p and hsa-miR-372-3p were found to be significantly dysregulated in the serum of s-IBM patients. These miRNAs are involved in differentiation and regeneration processes, thus possibly reflecting pathological mechanisms in s-IBM muscles and potentially representing disease biomarkers.

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MicroRNA-21 in Skin Fibrosis: Potential for Diagnosis and Treatment

Zhang

Lei

et al. 2017

Mol Diagn Ther

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Skin fibrosis is a common pathological process characterized by fibroblast proliferation and excessive deposition of extracellular matrix. However, the pathogenesis of the disease is still not clear. Previous studies have shown that microRNA-21 may play pivotal roles in the regulation of a variety of skin fibrosis, including keloid, scleroderma, and hypertrophic scar. In this review, we outline the structure, expression, and regulation of microRNA-21 and its role in fibrotic skin diseases. In future, it may be useful as a prognostic or diagnostic marker. However, there is a significant amount of work required to increase our current understanding of the role of microRNA-21 in skin fibrosis.

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microRNA level is raised in the hair shafts of patients with dematomyositis in comparison with normal subjects and patients with scleroderma

Abstract: Hair shaft miR-214 levels are useful for diagnosis and evaluating the disease severity of dermatomyositis. Hair microRNA levels may have potential to be a novel and less invasive biomarker.

Cited by 3 publications

References 19 publications

Recent progress in studies of miRNA and skin diseases

Recent progress in studies of miRNA and skin diseases

Serum-Circulating microRNAs in Sporadic Inclusion Body Myositis

MicroRNA-21 in Skin Fibrosis: Potential for Diagnosis and Treatment

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