Microalbuminuria as Predictor of Vascular Disease in Non-Diabetic Subjects

Yudkin, J; Forrest, R D; Jackson, C. A.

doi:10.1016/s0140-6736(88)92657-8

Cited by 753 publications

(218 citation statements)

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“…Our finding that proteinuria alone predicted CVD is also in accord with findings from other studies [1][2][3][4][5][6][7][8][9][10][11][12]. Microalbuminuria has been shown to be related to insulin resistance and hyperinsulinaemia [35][36][37][38][39], and other components of metabolic syndrome, including blood pressure [40,41], high levels of triglycerides and apolipoprotein B [42,43] and obesity [44].…”

Section: Discussionsupporting

confidence: 91%

“…Microalbuminuria and proteinuria predict cardiovascular disease (CVD) events, not only in diabetic [1][2][3][4][5][6][7], but also in non-diabetic individuals [5,[8][9][10][11][12]. Microalbuminuria was included in the WHO definition of the metabolic syndrome in 1998 [13], but since then there has been debate about microalbuminuria as a component of the metabolic syndrome [14].…”

Section: Introductionmentioning

confidence: 99%

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Proteinuria and metabolic syndrome as predictors of cardiovascular death in non-diabetic and type 2 diabetic men and women

et al. 2005

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Proteinuria and metabolic syndrome as predictors of cardiovascular death in non-diabetic and type 2 diabetic men and women

et al. 2005

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“…[1][2][3] In maturity onset diabetes and in elderly subjects, microalbuminuria predicts premature cardiovascular mortality 3,4 and in men of the general population aged Ͼ40 years is an independent risk factor for coronary artery disease. 5 In essential hypertension, microalbuminuria is a recognised marker of cardiovascular complications and a reliable predictor of ischaemic heart disease. 6 Conversely, the prognostic value of increased UAE Correspondence: G Crippa, MD, Hypertension Unit, Civil Hosptial, Via Taverna 49, 29100 Piacenza, Italy E-mail: crippagȰaltrimedia.it to blood pressure reduction, but angiotensin-converting enzyme inhibitors and angiotensin-II-receptor antagonists show an additional beneficial effect on urinary albumin excretion.…”

Section: Introductionmentioning

confidence: 99%

Microalbuminuria in essential hypertension

Crippa

2002

J Hum Hypertens

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Microalbuminuria (urinary albumin excretion equal to 30-300 mg/24 h) is a reliable indicator of premature cardiovascular mortality in diabetic patients and in the general population. In insulin-dependent and non-insulin-dependent diabetes mellitus microalbuminuria is a marker of initial diabetic nephropathy and predicts the evolution toward renal insufficiency. In essential hypertension the clinical and prognostic role of microalbuminuria is more controversial. While it is a recognised marker of cardiovascular complications and a reliable predictor of ischaemic heart disease, its prognostic value on the risk of progressive renal alterations is still uncertain because no prospective studies, taking microalbuminuria as a selection criterion and renal insufficiency as an end point, are available. Blood pressure control with antihypertensive drugs is accompanied by a reduction in urinary albumin excretion. The favourable effects of antihypertensive agents on microalbuminuria appear to be proportional

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“…lation. [14][15][16] Only few major population-based studies of hypertensive individuals which explore the…”

Section: Introductionmentioning

confidence: 99%

Microalbuminuria and its relation to cardiovascular disease and risk factors. A population-based study of 1254 hypertensive individuals

Feldt‐Rasmussen

Borch‐Johnsen

et al. 1997

J Hum Hypertens

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Microalbuminuria has been proposed as a potential jects were characterized by higher age and systolic BP, and a male predominance, as compared to normoalbumatherosclerotic risk factor in hypertensive individuals. The aim of this cross-sectional population study was to inuric hypertensive subjects. urinary albumin excretion than insufficiently treated or untreated participants. It is concluded that slightly elevparticipants without diabetes mellitus or renal/urinary tract disease had arterial hypertension. Age range was ated albumin excretion in the urine is not only a pressure-dependent functional phenomenon in the glomeru-30-70 years. Microalbuminuria (nocturnal urinary albumin excretion Ͼ15 g/min) occurred in 5%, and cardiolar vessel walls, but associated with permanent atherosclerotic abnormalities in the entire vascular vascular disease (previous acute myocardial infarction or electrocardiographic Q-waves) also in 5% of the system. study population. Microalbuminuric hypertensive subKeywords: acute myocardial infarction; antihypertensive agents; arterial hypertension; atherosclerotic risk factors; cardiovascular disease; microalbuminuria; urinary albumin excretion it is not known whether prevention of cardiovascu-

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Microalbuminuria as Predictor of Vascular Disease in Non-Diabetic Subjects

Cited by 753 publications

References 31 publications

Proteinuria and metabolic syndrome as predictors of cardiovascular death in non-diabetic and type 2 diabetic men and women

Proteinuria and metabolic syndrome as predictors of cardiovascular death in non-diabetic and type 2 diabetic men and women

Microalbuminuria in essential hypertension

Microalbuminuria and its relation to cardiovascular disease and risk factors. A population-based study of 1254 hypertensive individuals

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