Background: Diffused endothelial dysfunction in sepsis leads to an increase in systemic capillary permeability, the renal component manifesting as microalbuminuria. The degree of microalbuminuria correlates with the severity of the acute insult, the quantification of which may serve to predict sepsis and mortality in critically ill patients. Aim: To study the trend of microalbuminuria in sepsis patient, to evaluate microalbuminuria as novel biomarker of sepsis, To evaluate the capability of microalbuminuria for the prediction of ICU mortality. Methods: After exclusions, between November 2014 to May 2015, 50 consecutive adult patients were found eligible. Urine spot samples was collected at the time of ICU admission for Albumin Creatinine Ratio 1 and Albumin Creatinine Ratio 2 at 24hrs of ICU admission and Albumin creatinine Ratio 3. Results: Total of 50 patients were included into the study. The study included 56% of the patients as males and 44% as females. Out of 50 patients 78% of the patients had microalbuminuria, 66% of the patient were culture positive, out of which 79.49% of the patient had microalbuminuria. Majority of the patient (87.18%) with microalbuminuria require mechanical ventilation and the ICU stay was prolonged in survivor patients. Mortality rate was 61.54%. Microalbuminuria levels at 24 hours of admission among survivors and non survivors indicates its prognostic significance in ICU mortality. Conclusion: Microalbuminuria is a reliable marker of sepsis, At 48 hours of admission, increased levels of microalbuminuria compared to microalbuminuria levels at admission and 24 hour, indicates its prognostic significance among survivors and non survivors in critically ill patients.