Microalbuminuria in Elderly Hypertensives: Variability and Relation to Clinic and Ambulatory Blood Pressure

James, Michael; Fotherby,; Potter, John F.

doi:10.1093/ageing/22.suppl_2.p9-c

Cited by 10 publications

(10 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…21 Previous research in diabetes has found relationships between higher ABP and microalbuminuria in patients with diabetes 2-4,22-30 or essential hypertension. 31 Studies in younger subjects with type 1 diabetes have found that sleep ABP predicts the development of microalbuminuria even in subjects with normal office BP 2 and that nocturnal BP correlated directly with pathological evidence of renal injury. 32 In a cross-sectional study, Equiluz-Bruck et al 3 showed that middle-aged subjects with type 2 diabetes and microalbuminuria had significantly higher night systolic BP than nondiabetic, normoalbuminuric hypertensive controls, but their sample size was small, and office BP measurements were not obtained.…”

Section: Discussionmentioning

confidence: 99%

Office and Ambulatory Blood Pressure Are Independently Associated With Albuminuria in Older Subjects With Type 2 Diabetes

et al. 2006

View full text Add to dashboard Cite

Abstract-Blood pressure strongly predicts microalbuminuria and later progression to renal failure in people with diabetes.Ambulatory blood pressure monitoring seems to be superior to office blood pressure in predicting progression to microalbuminuria in type 1 diabetes. The associations of ambulatory blood pressure with office blood pressure and microalbuminuria in type 2 diabetes remain unclear. We studied the association of office blood pressure taken with an automated device and ambulatory blood pressure with spot urine albumin:creatinine ratio in 1180 older people with type 2 diabetes participating in the Informatics for Diabetes Education and Telemedicine Study. Office and awake systolic blood pressure were independently associated with albuminuria (PϽ0.001 for both) in a multivariate linear regression analysis that adjusted for age, gender, duration of diabetes, hemoglobin A1c, number of antihypertensive medications, and use of an angiotensin-converting enzyme inhibitor or angiotensin receptor blocker. Twelve percent of participants had well-controlled office blood pressure but not ambulatory blood pressure, whereas 14% had well-controlled ambulatory but not office blood pressure. The prevalence of microalbuminuria and macroalbuminuria in these subgroups was intermediate between those with well-controlled or uncontrolled blood pressure by both methods. We found, in a multiethnic group of older subjects with type 2 diabetes, that office systolic blood pressure and awake systolic ambulatory blood pressure exhibited independent associations with degree of albuminuria.

show abstract

Section: Discussionmentioning

confidence: 99%

Office and Ambulatory Blood Pressure Are Independently Associated With Albuminuria in Older Subjects With Type 2 Diabetes

et al. 2006

View full text Add to dashboard Cite

show abstract

“…On the other hand, clinic SBP/PP and morning PP were significantly associated with increased UAR across the 3 age groups. Elevated PP has been shown to be associated with increased UAR in both middle‐aged 33,34 and elderly participants 35 regardless of whether clinic or out‐of‐clinic BP was used. In a study of the very elderly (older than 80 years), both clinic and ambulatory SBP/DBP were closely associated with increased UAR 32 .…”

Section: Discussionmentioning

confidence: 99%

Age‐Specific Impact of Self‐Monitored Pulse Pressure on Hypertensive Target Organ Damage in Treated Hypertensive Patients

Eguchi

Matsui²,

Shibasaki³

et al. 2007

J of Clinical Hypertension

View full text Add to dashboard Cite

The authors examined the relationship of clinic and self-measured pulse pressure with target organ damage in 597 treated hypertensive patients without clinical evidence of renal dysfunction or a history of heart failure. The cross-sectional relationships of plasma brain natriuretic peptide (BNP) and urinary albumin/creatinine ratio with clinic and self-monitored pulse pressures were estimated in age tertile groups: younger than 67 years (n=193), 67 to 75 years (n=216), and older than 75 years (n=188), controlling for various confounding factors. In multivariable analyses, both clinic and self-monitored higher pulse pressures were associated with increased urinary albumin/creatinine ratio in all 3 age groups. Self-monitored higher pulse pressure, but not clinic pulse pressure, was consistently associated with increased BNP in the younger and middle-aged patients. In the very old (older than 75 years), however, there were no consistent associations between pulse pressure measures and BNP. More studies are needed in the evaluation of cardiac risk with hemodynamic measures in the very old.

show abstract

“…All studies of u-protein measurements have to deal with the problem of a large variation in protein excretion at different times of the day (22) or from day to day (23). All studies of u-protein measurements have to deal with the problem of a large variation in protein excretion at different times of the day (22) or from day to day (23).…”

Section: Discussionmentioning

confidence: 99%

Microproteinuria and Long-term Prognosis with Respect to Renal Function and Survival in Normotensive and Hypertensive Women: A 24-year Follow-up of a Representative Population Sample of Women in Gothenburg, Sweden

Kristjansson

Ljungman

Bengtsson

et al. 2001

Scandinavian Journal of Urology and Nephrology

View full text Add to dashboard Cite

This study demonstrated that both a positive Albustix test and microproteinuria were associated with hypertension. Hypertension at baseline increased the risk for death during the follow-up period, while neither albuminuria, defined as a positive Albustix test, nor microproteinuria was associated with an impaired long-term prognosis with respect to renal function or survival in this cohort of Swedish middle-aged women during 24 years of follow-up. Microproteinuria in otherwise healthy normotensive or hypertensive women does not appear to impair the long-term prognosis.

show abstract

Microalbuminuria in Elderly Hypertensives: Variability and Relation to Clinic and Ambulatory Blood Pressure

Cited by 10 publications

References 0 publications

Office and Ambulatory Blood Pressure Are Independently Associated With Albuminuria in Older Subjects With Type 2 Diabetes

Office and Ambulatory Blood Pressure Are Independently Associated With Albuminuria in Older Subjects With Type 2 Diabetes

Age‐Specific Impact of Self‐Monitored Pulse Pressure on Hypertensive Target Organ Damage in Treated Hypertensive Patients

Microproteinuria and Long-term Prognosis with Respect to Renal Function and Survival in Normotensive and Hypertensive Women: A 24-year Follow-up of a Representative Population Sample of Women in Gothenburg, Sweden

Contact Info

Product

Resources

About