Microproteinuria and Long-term Prognosis with Respect to Renal Function and Survival in Normotensive and Hypertensive Women: A 24-year Follow-up of a Representative Population Sample of Women in Gothenburg, Sweden

Kristjansson, Karl; Ljungman, Susanne; Bengtsson, Calle; Björkelund, Cecilia; Sigurdsson, Jóhann Á.

doi:10.1080/00365590151030868

Cited by 4 publications

(2 citation statements)

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“…Medical examinations at baseline were subsequently combined with self testing of blood pressure of consenting women who wanted to neutralize midlife risk factors for kidney disorders, stroke and small vessel disease [6,14,21]. Consenting women were informed here that albuminuria predicts cardiovascular disorders of elderly persons indicating that aging further impaired regeneration of impaired endothelium [9,14,41,57].…”

Section: Discussionmentioning

confidence: 99%

“…Swedish women with thickening of the arterial intima are correlated with autoantibodies against transformed LDL-associated phospholipids while small vessel disease was not tested [13]. Medical studies further disclose that women with hypertension and proteinuria are at direct risk for kidney disorders predicting higher mortality as shown in a 24-year follow-up study in Sweden [14]. Male cohorts of the Karolinska University show that autoantibodies against transformed LDL-associated phospholipids are correlated with carotid intima thickness, hypertension and hyperinsulinemia whereby the followup studies subsequently show late arterial disorders of men at risk [15,16].…”

Section: Introductionmentioning

confidence: 99%

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Women with overweight, mixed hyperlipidemia, intolerance to glucose and diastolic hypertension

Korth¹

2014

Health

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Primarily healthy women who attended a practice of General Medicine were examined and coded data were evaluated using two statistical methods (n = 248, aged 36 ± 14 years). It was found that participants with LDL-related (mixed) hyperlipidemia showed higher blood pressure, a higher proportion of alcohol problems and/or smoking compared to normolipidemic women (p ≤ 0.05). These hyperlipidemic women who reported alcohol problems and/or smoking more often showed proteinuria and/or hematuria, rise of LDL/HDL, critical fasting blood glucose and lower HDL-cholesterol compared to hyperlipidemic women reporting healthy lifestyle (p ≤ 0.05). Likewise, high triglycerides were associated with rise of blood pressure and intolerance to glucose (p ≤ 0.05) and also with elevated total cholesterol. Alcohol-related hypertriglyceridemia overlapped with diastolic hypertension, rise of body weight and urine pathology, lowering of HDL-cholesterol and critical fasting blood glucose. The motivating message was that women with mixed hyperlipidemia and healthy lifestyle had functionally renal endothelium and healthy HDL-related baseline measures. Altogether, LDLrelated hyperlipidemia and/or high triglycerides were correlated with diastolic hypertension whereby critical alcohol consumption declined renal endothelium and lowered HDL-cholesterol implicating baseline strategies to neutralize early risk factors.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Women with overweight, mixed hyperlipidemia, intolerance to glucose and diastolic hypertension

Korth¹

2014

Health

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Gender, obesity, alcohol use, hyperlipidemia, hypertension and decline of renal endothelial barriers

Korth¹

2006

The Journal of Men's Health & Gender

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Background: Raised body weight and hypertension are locally relevant risk factors. Patients were examined in a Bavarian General Medicine Practice to investigate the relationship between raised body weight, hypertriglyceridemia and alcohol misuse with raised blood pressure or abnormal morning urines. Methods: The risk factors evaluated in this study of primary care patients were obesity, overweight, hypertriglyceridemia, self-reported alcohol misuse, raised blood pressure and proteinuria and/or hematuria in men (n = 86, 31 AE 12 years) and women (n = 160, 30 AE 10 years). Results: Men or women with obesity (BMI 2 ) or alcohol misuse (AHA 1 ) had significantly higher systolic or diastolic blood pressure and significantly lower HDL levels (p < 0.05) compared with men or women of normal weight or without alcohol problems and the ratio of serum albumin to triglycerides was significantly lower with obesity or alcohol misuse (p = 0.001, p = 0.001, respectively). Men with hypertriglyceridemia tended to be overweight and showed significantly higher blood pressure than men with normal triglyceride levels (p < 0.05). Obese men showed significantly higher diastolic blood pressure compared to obese women (p = 0.049). An increase in systolic (p = 0.0026) or diastolic (p = 0.0002) blood pressure was significantly associated with raised body weight (BMI 1 + BMI 2 ), while a rise in diastolic blood pressure was linked with alcohol misuse (p = 0.0005) using multivariate modelling. Proteinuria and/or hematuria in men's morning urine samples were significantly associated with misuse of alcohol or nicotine (p = 0.041, p = 0.045, respectively). Conclusion: The data showed significant associations between raised systolic or diastolic blood pressure and raised body weight. Raised diastolic blood pressure or proteinuria and/or hematuria were associated with misuse of alcohol and indicated a decline in renal endothelial barriers.

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Renal function and cardiovascular risk markers in a remote Australian Aboriginal community

McDonald

Maguire

Hoy

2003

Nephrology Dialysis Transplantation

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The high prevalence of markers of renal disease in this community was consistent with their high rates of ESRD. The distribution of microalbuminuria suggested a 'cohort effect', representing a group who will progress to overt albuminuria. The powerful association of renal disease markers with CV risk factors confirms a strong link between renal and CV disease in the early, asymptomatic stages of each. Thus, pathologic albuminuria, in part, might be a manifestation of the metabolic/haemodynamic syndrome and both conditions might arise out of a common menu of risk factors. Hence, a single agenda of primary and secondary intervention may benefit both.

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Microproteinuria and Long-term Prognosis with Respect to Renal Function and Survival in Normotensive and Hypertensive Women: A 24-year Follow-up of a Representative Population Sample of Women in Gothenburg, Sweden

Cited by 4 publications

References 31 publications

Women with overweight, mixed hyperlipidemia, intolerance to glucose and diastolic hypertension

Women with overweight, mixed hyperlipidemia, intolerance to glucose and diastolic hypertension

Gender, obesity, alcohol use, hyperlipidemia, hypertension and decline of renal endothelial barriers

Renal function and cardiovascular risk markers in a remote Australian Aboriginal community

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