Microalgal Nanobiotechnology and Its Applications—A Brief Overview

Adelere, Isiaka Adedayo; Lateef, Agbaje

doi:10.1007/978-981-33-4777-9_8

Cited by 17 publications

(4 citation statements)

References 114 publications

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“…Therefore, it is necessary to develop an environment friendly method to synthesize AgNPs using gentle techniques and nontoxic chemicals during the synthesis process 12,13 . Recently, application of biomaterials for AgNPs synthesis have attracted the attention of investigators, the biomaterials include plant, fungi, bacteria and algae, metabolites of arthropods, enzymes animal and agricultural wastes materials et al [14][15][16][17][18][19][20][21][22][23] .Fungi can produce large amount of metabolites compared to other microorganisms, making it more suitable for nanoparticles production 24,25 . Many articles have reported that fungi have the ability to synthesize nanoparticles 26,27 .…”

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confidence: 99%

Fungus-mediated green synthesis of nano-silver using Aspergillus sydowii and its antifungal/antiproliferative activities

Wang

Xue

Wang

et al. 2021

Sci Rep

101

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Due to the increasing demand for eco-friendly, cost-effective and safe technologies, biosynthetic metal nanoparticles have attracted worldwide attention. In this study, silver nanoparticles (AgNPs) were extracellularly biosynthesized using the culture supernatants of Aspergillus sydowii. During synthesis, color change was preliminarily judge of the generation of AgNPs, and the UV absorption peak at 420 nm further confirms the production of AgNPs. Transmission electron microscopy and X-ray diffraction were also used to identify the AgNPs. The results shows that AgNPs has crystalline cubic feature and is a polydisperse spherical particle with size between 1 and 24 nm. Three main synthesis factors (temperature, pH and substrate concentration) were optimized, the best synthesis conditions were as follows 50 °C, 8.0 and 1.5 mM. In the biological application of AgNPs, it shows effective antifungal activity against many clinical pathogenic fungi and antiproliferative activity to HeLa cells and MCF-7 cells in vitro. Our research finds a new path to biosynthesis of AgNPs in an eco-friendly manner, and bring opportunity for biomedical applications in clinic.

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mentioning

confidence: 99%

Fungus-mediated green synthesis of nano-silver using Aspergillus sydowii and its antifungal/antiproliferative activities

Wang

Xue

Wang

et al. 2021

Sci Rep

101

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“…This method is swift, economical, and environmentally friendly; it permits the usage of very small amounts of chemicals accompanied by limited toxic byproducts [4]. The method involves the use of biological molecules ranging from microorganisms (bacteria, fungi, and microalgae), enzymes, animal metabolites, plant extract/biomass, to agrowastes as reducing and capping agents in the synthesis of nanoparticles [5][6][7]. However, the plant-mediated synthesis of nanoparticles (NPs) has attracted much research attention due to the ease of preparation of NPs, abundance of plants, the possession of wide arrays of bioactive compounds, and their many applications in biomedical elds.…”

Section: Introductionmentioning

confidence: 99%

Novel multitasking gold nanoparticles biosynthesized by Cassia fistula: antifungal, anti- obesity, anti-diabetic, and anti-ulcer activities

Ajayi,

Adebayo,

Lateef

2023

Preprint

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In this study, an aqueous extract of Cassia fistula leaves (CFLE) was employed for the biosynthesis of gold nanoparticles (CFL-AuNPs). The CFL-AuNPs were characterized and evaluated for antifungal, anti-obesity, anti-diabetic, and anti-ulcer activities in vitro. The characteristic change in color from colorless to wine red and the UV-visible absorption at 560 nm confirmed the phytosynthesis of CFL-AuNPs. The particles were anisotropic, with spherical and irregular shapes. Fourier transform infrared spectroscopy (FTIR) analysis revealed peaks that correspond to the -OH compound of phenols or alcohol, -NH2, -N-H amines of protein, and -C=O/-C-O of carbonyl groups. CFL-AuNPs were active against Aspergillus flavus (50.70%), A. fumigatus (47.73%), A. niger (44.29%), and Fusarium solani (47.65%). Similarly, CFL-AuNPs exhibited lipase inhibitory activity of 88.93±0.81% with an IC50 of 121.38 µg/ml comparable with standard Orlistat (89.46±0.50%) having an IC50 of 120.51 µg/ml showing anti-obesity potential. CFL-AuNPs also inhibited alpha-glucosidase activity by 42.93±4.12%. Proton potassium (H+-/K+-) ATPase inhibitory assay of CFL-AuNPs showed activity of 84.60±9.54% at IC50 <75 µg/ml which was more efficient than acetaminophen (IC50 of 187.6 µg/ml) with promising anti-ulcer activity. The phytosynthesized CFL-AuNPs exhibited a multitasking nature as demonstrated by the antifungal, anti-obesity, anti-diabetic, and anti-ulcer activities, making it a promising candidate for further study as a potential therapeutic agent for the treatment of multiple diseases. As far as we are aware, this is the foremost report on the in vitro evaluation of the anti-ulcer activities of AuNPs.

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“…This is due to several advantages of the process which include simplicity, high formation of nanoparticles, eco-friendliness and enhanced biocompatibility of MeNPs [ 10 ]. As a result, varieties of metabolites from plants, microorganisms and animals have been used extensively for the biosynthesis of MeNPs for diverse applications [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Recent advances in functionalization of nanotextiles: A strategy to combat harmful microorganisms and emerging pathogens in the 21st century

Aguda

Lateef

2022

Heliyon

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Microalgal Nanobiotechnology and Its Applications—A Brief Overview

Cited by 17 publications

References 114 publications

Fungus-mediated green synthesis of nano-silver using Aspergillus sydowii and its antifungal/antiproliferative activities

Fungus-mediated green synthesis of nano-silver using Aspergillus sydowii and its antifungal/antiproliferative activities

Novel multitasking gold nanoparticles biosynthesized by Cassia fistula: antifungal, anti- obesity, anti-diabetic, and anti-ulcer activities

Recent advances in functionalization of nanotextiles: A strategy to combat harmful microorganisms and emerging pathogens in the 21st century

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