Microangiopathy of the skin and the effect of leg compression in patients with chronic venous insufficiency

Abu-Own, A.; Shami, S. K.; Chittenden, S. J.; Farrah, J.; Scurr, J. H.; Smith, Philip

doi:10.1016/s0741-5214(94)70220-9

Cited by 59 publications

(28 citation statements)

References 35 publications

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“…The highest increase, up to 33%, was measured under a moderate bandage pressure of 20 to 30 mm Hg, but LDF was also significantly increased by 28% with a compression pressure in the higher range of 31 to 40 mm Hg. These findings are in agreement with LDF data under compression reported by Abu-Own et al 30,36 They also showed a similar flux increase in skin areas of the distal lower leg up to a pressure of 50 to 60 mm Hg, both in healthy individuals and in patients with lipodermatosclerosis, in the sitting position.…”

Section: Discussionsupporting

confidence: 92%

Compression therapy in mixed ulcers increases venous output and arterial perfusion

Mosti¹,

Iabichella²,

Partsch³

2012

Journal of Vascular Surgery

159

136

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In patients with mixed ulceration, an ankle-brachial pressure index >0.5 and an absolute ankle pressure of >60 mm Hg, inelastic compression of up to 40 mm Hg does not impede arterial perfusion but may lead to a normalization of the highly reduced venous pumping function. Such bandages are therefore recommended in combination with walking exercises as the basic conservative management for patients with mixed leg ulcers.

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Section: Discussionsupporting

confidence: 92%

Compression therapy in mixed ulcers increases venous output and arterial perfusion

Mosti¹,

Iabichella²,

Partsch³

2012

Journal of Vascular Surgery

159

136

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“…15 The pressure in the lower leg veins is 60-80 mmHg while standing and about 30-50 mmHg in the sitting position. Therefore the narrowing effect of a compression device exerting a pressure of 30 mmHg will be minimal.…”

Section: Discussionmentioning

confidence: 99%

Do we still need compression bandages? Haemodynamic effects of compression stockings and bandages

Partsch¹

2006

Phlebology

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Objective: To compare haemodynamic data obtained with elastic compression stockings and inelastic compression material applied with different pressure ranges on the lower extremities. Methods: Haemodynamic effects of compression therapy were demonstrated by measuring venous flow velocity, venous volume, venous reflux and venous pumping function using radioisotopes, phlebography, water displacement volumetry, duplex, air plethysmography, foot volumetry and phlebodynamometry. Results: Light-compression stockings are able to increase venous blood flow velocity in the supine position and to prevent leg swelling after prolonged sitting and standing. In the upright position an interface pressure of more than 50 mmHg is needed for an intermittent occlusion of incompetent veins and for a reduction of ambulatory venous hypertension during walking. Such high interface pressures may rather be achieved by short-stretch, multilayer bandages than by an elastic stocking. Conclusion: Elastic compression stockings exerting interface pressures up to 40 mmHg are effective in preventing or reducing oedema. Multilayer compression bandages with a pressure over 40 mmHg additionally improve severely disturbed venous pumping function.

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“…128 The acceleration of blood flow in the microcirculation, facilitated by compression, has been noted to favor white cell detachment from the endothelium and prevent further adhesion. 91 Taken together, this presumably allows fibrinolytic processes and inflammatory cells within the extravascular tissue to remove protein deposits without them being constantly replaced through plasma outflow; thus, resolving one of the key inflammatory stimuli. Observations consistent with this hypothesis have been made previously, 80 and intermittent pneumatic compression therapy has been demonstrated to stimulate fibrinolytic activity systemically.…”

Section: Translations/interventionsmentioning

confidence: 99%

“…These limbs demonstrate signs of elevated inflammatory cell infiltrates 87,88 known to be induced by fibrin(ogen) derived peptides. 22,89,90 Once there, these cells are proposed to increase local concentrations of proteases, such as MMPs and reactive oxygen species in the local environment 91 causing oxidative stress, leading to the damage of vessel walls and thereby facilitating the release of yet further fibrinogen into the extracellular space (Fig. 3b).…”

mentioning

confidence: 99%

Provisional Matrix Deposition in Hemostasis and Venous Insufficiency: Tissue Preconditioning for Nonhealing Venous Ulcers

Parker

Broadbent

McGovern

et al. 2015

Advances in Wound Care

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Microangiopathy of the skin and the effect of leg compression in patients with chronic venous insufficiency

Cited by 59 publications

References 35 publications

Compression therapy in mixed ulcers increases venous output and arterial perfusion

Compression therapy in mixed ulcers increases venous output and arterial perfusion

Do we still need compression bandages? Haemodynamic effects of compression stockings and bandages

Provisional Matrix Deposition in Hemostasis and Venous Insufficiency: Tissue Preconditioning for Nonhealing Venous Ulcers

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