Microarray patches: Breaking down the barriers to contraceptive care and HIV prevention for women across the globe

Paredes, Alejandro J.; Ramöller, Inken K.; McKenna, Peter E.; Abbate, Marco; Volpe‐Zanutto, Fabiana; Vora, Lalitkumar K.; Kilbourne-Brook, Maggie; Jarrahian, Courtney; Moffatt, Kurtis; Zhang, Chunyang; Tekko, Ismaiel A.; Donnelly, Ryan F.

doi:10.1016/j.addr.2021.04.002

Cited by 54 publications

(48 citation statements)

References 100 publications

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“…Rats with or without a vaccine were administrated with these microparticles; the vaccinated rats could be identified by exposing the rats to near-infrared light for quantum dot detection [ 96 ]. Microneedles are also used to deliver vaccines and antiretroviral drugs for the prevention and treatment of AIDS due to their convenience and could provide higher antibody levels [ 40 , 97 ]. Boopathy et al fabricated microneedles encapsulating antigen ovalbumin (OVA) in regenerated SF protein with a dissolving PAA polymer backing.…”

Section: Applicationsmentioning

confidence: 99%

Advances of Microneedles in Biomedical Applications

Xuan

et al. 2021

Molecules

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A microneedle (MN) is a painless and minimally invasive drug delivery device initially developed in 1976. As microneedle technology evolves, microneedles with different shapes (cone and pyramid) and forms (solid, drug-coated, hollow, dissolvable and hydrogel-based microneedles) have been developed. The main objective of this review is the applications of microneedles in biomedical areas. Firstly, the classifications and manufacturing of microneedle are briefly introduced so that we can learn the advantages and fabrications of different MNs. Secondly, research of microneedles in biomedical therapy such as drug delivery systems, diagnoses of disease, as well as wound repair and cancer therapy are overviewed. Finally, the safety and the vision of the future of MNs are discussed.

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Section: Applicationsmentioning

confidence: 99%

Advances of Microneedles in Biomedical Applications

Xuan

et al. 2021

Molecules

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“…The basic mechanism of skin-targeted cargo delivery with dissolving microneedles relies on mechanical and painless penetration of the outermost skin layers to generate transient microchannels and subsequent dissolution of microneedles with embedded biocargos in the targeted cutaneous microenvironment. Because dissolvable microneedles breach the outermost skin layers, they can effectively deliver a broad range of bioactive compounds, including proteins, hydrophobic and hydrophilic smallmolecule agents, and even recombinant viral vectors (Amani et al, 2021;Bachy et al, 2013;Erdos et al, 2020;Korkmaz et al, 2021b;Paredes et al, 2021b;Ye et al, 2018). Application-driven optimization of the geometry and materials of dissolving MNAs affords the capacity to achieve spatially and temporally controlled skin-targeted delivery of vaccine components and therapeutics in a reproducible manner.…”

Section: Dissolving Mna-directed Drug Deliverymentioning

confidence: 99%

Research Techniques Made Simple: Skin-Targeted Drug and Vaccine Delivery Using Dissolvable Microneedle Arrays

Balmert

Ghozloujeh

Carey

et al. 2021

Journal of Investigative Dermatology

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Skin-targeted drug delivery is broadly employed for both local and systemic therapeutics and is an important tool for discovery efforts in cutaneous biology. Recently, emerging technologies support efforts toward skintargeted biocargo delivery for local and systemic therapeutic benefit. Effective targeting of bioactive molecules, including large (molecular weight > 500 Da) or complex (hydrophilic and charged) molecules, to defined cutaneous microenvironments is intrinsically challenging owing to the protective barrier function of the skin. Dissolvable microneedle arrays (MNAs) have proven to be a promising technology to address the unmet need for controlled, minimally invasive, and reliable delivery of a wide range of biocargos to the skin. In this paper, we describe the unique properties of the skin that make it an attractive target for vaccine delivery, for immunemodulating therapies, and for systemic drug delivery and the structural characteristics of the skin that present obstacles to efficient intracutaneous and transdermal delivery of bioactive molecules. We provide an overview of MNA fabrication and the characteristics and mechanisms of dissolvable MNA cargo delivery to the cutaneous microenvironment. We present a representative example of a clinical application of MNAs and discuss future directions for MNA development and applications.

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“…Le contraceptif n'est alors plus visible. Selon la surface du système, la dose peut être adaptée et la durée de libération du principe actif prolongée, pour une semaine, voire un mois [29]. Cette technique a déjà été utilisée pour des vaccins.…”

Section: La Contraception Masculine Hormonaleunclassified

Contraception au futur

Sitruk-Ware

2021

Med Sci (Paris)

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L’amélioration des méthodes contraceptives et la recherche de nouvelles approches innovantes, avec un bénéfice médical ajouté, permettraient de satisfaire plus de couples, aux différentes étapes de leur vie reproductive. Les systèmes de délivrance s’améliorent, visant à une utilisation autonome et à une longue durée d’action, ce qui en facilite ainsi l’observance. Auto-injections, patchs à microaiguilles, anneaux vaginaux multipores, qui délivrent des molécules contraceptives et des molécules anti-infectieuses, promettent ainsi une double prévention, la grossesse non désirée et les maladies sexuellement transmissibles. Enfin, de nouveaux systèmes intra-utérins et de contraception permanente sont à l’étude. La recherche de nouveaux contraceptifs est une nécessité et doit se poursuivre, afin de diminuer la mortalité maternelle liée aux grossesses multiples et aux avortements, qui restent souvent à risque dans beaucoup de pays.

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Microarray patches: Breaking down the barriers to contraceptive care and HIV prevention for women across the globe

Cited by 54 publications

References 100 publications

Advances of Microneedles in Biomedical Applications

Advances of Microneedles in Biomedical Applications

Research Techniques Made Simple: Skin-Targeted Drug and Vaccine Delivery Using Dissolvable Microneedle Arrays

Contraception au futur

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