Microarray profiles of human basal cell carcinoma: Insights into tumor growth and behavior

Howell, Brandon G.; Solish, Nowell; Lü, Chen; Watanabe, Hideaki; Mamelak, Adam J.; Freed, Irwin; Wang, Binghe; Sauder, Daniel N.

doi:10.1016/j.jdermsci.2005.02.004

Cited by 35 publications

(45 citation statements)

References 62 publications

(59 reference statements)

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“…TIMP-1 was rarely detected in invasive BCC epithelium, while stromal expression was abundant in accordance with gene array data [22]. Macrophages showed significantly more TIMP-1 immunopositivity in the nonimmunosuppressed group, whereas the total amount of macrophages did not differ significantly between the groups as assessed by CD163 immunostaining (data not shown).…”

Section: Discussionsupporting

confidence: 83%

Differential expression of stromal MMP-1, MMP-9 and TIMP-1 in basal cell carcinomas of immunosuppressed patients and controls

et al. 2007

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Matrix metalloproteinases (MMPs) have an important role in the initiation, growth, and invasion of malignant tumors. Basal cell cancer (BCC) is the most common human malignancy. The risk of BCC is 10-16 times higher among organ transplant recipients compared with the nontransplanted population. The aim of this study was to compare the expression of several MMPs and their tissue inhibitors (TIMPs) in BCCs from kidney transplant recipients and controls. Expression of MMPs-1, -7, -8, -9, -10, -13, -26, and TIMPs-1 and -3 was evaluated by immunohistochemistry in 25 samples of BCC of kidney transplant recipients and 25 matched controls representing superficial and nodular subtypes. No significant differences were detected in MMP expression of BCC tumor cells between immunocompetent and immunodeficient patients. However, MMPs-1 and -9 and TIMP-1 were expressed more frequently in stromal macrophages in the BCCs of immunocompetent patients. When tumor subtypes were compared irrespective of the patient group, more MMP-1-positive fibroblasts and MMP-9-positive neutrophils were detected in the superficial subtype, while stromal MMP-10 expression was more abundant in nodular tumors. Our results suggest that abundant peritumoral expression of TIMP-1 in non-immunocompromised patients limits ECM degradation permissive for cancer cell migration.

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Section: Discussionsupporting

confidence: 83%

Differential expression of stromal MMP-1, MMP-9 and TIMP-1 in basal cell carcinomas of immunosuppressed patients and controls

et al. 2007

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“…20 Although these results suggest a link between SHH misregulation and BCL2, results on BCL2 gene expression in BCCs have been inconsistent. 25 MYCN (also known as the N-myc proto-oncogene)…”

Section: The Bcl2 Proto-oncogenementioning

confidence: 99%

The molecular genetics underlying basal cell carcinoma pathogenesis and links to targeted therapeutics

Iwasaki

Srivastava

Moy

et al. 2012

Journal of the American Academy of Dermatology

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“…The most useful and rapid method for evaluating hair growth promotion is by determining the dermal papilla growth rate as influenced by various samples [4]. After that, more detailed studies should be performed such as in vivo assays [5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Hair growth regulation by the extract of aromatic plant Erica multiflora

Kawano

Han

Kchouk³

et al. 2009

J Nat Med

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Hair growth problems can affect human physical and mental health and are of particular relevance during the aging process. In an effort to resolve such problems, we attempted to find plants having hair growth regulation activity and thus collected plant extracts from Tunisia for bioprospecting purposes. Among them, we investigated the Erica multiflora extract to evaluate the hair growth promotion activity by using the MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide) assay and cell cycle assay on human dermal papilla cells in vitro and an administration assay on mouse dorsal skin in vivo. The results showed that the Erica multiflora extract promotes dermal papilla cell growth and cell cycle with high activity, and induced hair growth in vivo by induction of anagen phase from telogen phase.

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Microarray profiles of human basal cell carcinoma: Insights into tumor growth and behavior

Cited by 35 publications

References 62 publications

Differential expression of stromal MMP-1, MMP-9 and TIMP-1 in basal cell carcinomas of immunosuppressed patients and controls

Differential expression of stromal MMP-1, MMP-9 and TIMP-1 in basal cell carcinomas of immunosuppressed patients and controls

The molecular genetics underlying basal cell carcinoma pathogenesis and links to targeted therapeutics

Hair growth regulation by the extract of aromatic plant Erica multiflora

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