Microarrays and microneedle arrays for delivery of peptides, proteins, vaccines and other applications

Chandrasekhar, Saradha; Iyer, Lavanya K.; Panchal, Jainik P.; Topp, Elizabeth M.; Cannon, John F.; Ranade, Vasant

doi:10.1517/17425247.2013.797405

Cited by 51 publications

(36 citation statements)

References 134 publications

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“…There are numerous journal papers that have reviewed different types of DD technologies (Wu et al, 2012;Chandrasekhar et al, 2013;Fazil et al, 2013;Kamboj et al, 2013;Tuan-Mahmood et al, 2013;Ita, 2014;Nalwa, 2014;Wolff, 2014) and specific drug deliveries, such as insulin (Martanto et al, 2004;Zahn et al, 2005;Ito et al, 2006;Khanna et al, 2008;Taylor & Sahota, 2013;Bronger, 2014;Natayan, 2014). A number of review papers have also discussed specific technologies, e.g.…”

Section: Dd Routesmentioning

confidence: 99%

“…Problems can also arise from the TDP's peeling off due to the long periods for which they are required to be applied. Several approaches have been researched to overcome the problems with TDPs and allow delivery of compounds like proteins and DNA (Benson & Namjoshi, 2008;Daugimont et al, 2010;Garland et al, 2012;Chandrasekhar et al, 2013;Katsumi et al, 2014), so that they can permeate through the skin.…”

Section: Introductionmentioning

confidence: 99%

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Microneedles for drug delivery: trends and progress

2014

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In recent years, there has been a surge in the research and development of microneedles (MNs), a transdermal delivery system that combines the technology of transdermal patches and hypodermic needles. The needles are in the hundreds of micron length range and therefore allow relatively little or no pain. For example, biodegradable MNs have been researched in the literature and have several advantages compared with solid or hollow MNs, as they produce non-sharp waste and can be designed to allow rapid or slow release of drugs. However, they also pose a disadvantage as successful insertion into the stratum corneum layer of the skin relies on sufficient mechanical strength of the biodegradable material. This review looks at the various technologies developed in MN research and shows the rapidly growing numbers of research papers and patent publications since the first invention of MNs (using time series statistical analysis). This provides the research and industry communities a valuable synopsis of the trends and progress being made in this field.

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Section: Dd Routesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Microneedles for drug delivery: trends and progress

2014

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“…In addition to DNA microarrays, protein chips are also utilized in drug discovery (Chandrasekhar et al 2013). The feasibility of using protein microarray in HTS was established at the beginning of this century (MacBeath and Schreiber 2000; Zhu et al 2000).…”

Section: Protein Microarraymentioning

confidence: 99%

Application of chemical biology in target identification and drug discovery

et al. 2015

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Drug discovery and development is vital to the well-being of mankind and sustainability of the pharmaceutical industry. Using chemical biology approaches to discover drug leads has become a widely accepted path partially because of the completion of the Human Genome Project. Chemical biology mainly solves biological problems through searching previously unknown targets for pharmacologically active small molecules or finding ligands for well-defined drug targets. It is a powerful tool to study how these small molecules interact with their respective targets, as well as their roles in signal transduction, molecular recognition and cell functions. There have been an increasing number of new therapeutic targets being identified and subsequently validated as a result of advances in functional genomics, which in turn led to the discovery of numerous active small molecules via a variety of high-throughput screening initiatives. In this review, we highlight some applications of chemical biology in the context of drug discovery.

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“…The principal applications of these microneedle arrays involve fluid sampling [24] and extraction [25] since they provide the opportunity to overcome the skin barrier and thereby reach dermal biofluids, which are more reflective of systemic levels of key analytes. This novel technology can be used as a therapeutic tool for transdermal drug delivery, including insulin, and more recently as a diagnostic tool for the analysis of the biofluid contents.…”

Section: Microneedle Technologymentioning

confidence: 99%