Microbats appear to have adult hippocampal neurogenesis, but post-capture stress causes a rapid decline in the number of neurons expressing doublecortin

Chawana, Richard; Alagaili, Abdulaziz N.; Patzke, Nina; Spocter, Muhammad A.; Mohammed, Osama B.; Kaswera, Consolate; Gilissen, Emmanuel; Bennett, Nigel C.; Ihunwo, Amadi O.; Manger, Paul P.R.

doi:10.1016/j.neuroscience.2014.07.063

Cited by 25 publications

(25 citation statements)

References 42 publications

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“…2F). The absence of AHN was confirmed in the wild North American brown bat (Eptesicus fuscus ]), but not in a series of other African bats (Chawana et al 2014), in which the expression of DCX immunoreactivity depended on the duration of posttrapping handling stress. Interestingly, our laboratory-bred tropical bats that were adapted to human handling and perfused within minutes after catching were also AHN negative using multiple AHN markers (Amrein et al 2007).…”

Section: Evidence Of Hippocampal Neurogenesis In Other Wild and Domesmentioning

confidence: 84%

Adult Hippocampal Neurogenesis in Natural Populations of Mammals

Amrein

2015

Cold Spring Harb Perspect Biol

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This review will discuss adult hippocampal neurogenesis in wild mammals of different taxa and outline similarities with and differences from laboratory animals. It begins with a review of evidence for hippocampal neurogenesis in various mammals, and shows the similar patterns of age-dependent decline in cell proliferation in wild and domesticated mammals. In contrast, the pool of immature neurons that originate from proliferative activity varies between species, implying a selective advantage for mammals that can make use of a large number of these functionally special neurons. Furthermore, rapid adaptation of hippocampal neurogenesis to experimental challenges appears to be a characteristic of laboratory rodents. Wild mammals show species-specific, rather stable hippocampal neurogenesis, which appears related to demands that characterize the niche exploited by a species rather than to acute events in the life of its members. Studies that investigate adult neurogenesis in wild mammals are not numerous, but the findings of neurogenesis under natural conditions can provide new insights, and thereby also address the question to which cognitive demands neurogenesis may respond during selection.

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Section: Evidence Of Hippocampal Neurogenesis In Other Wild and Domesmentioning

confidence: 84%

Adult Hippocampal Neurogenesis in Natural Populations of Mammals

Amrein

2015

Cold Spring Harb Perspect Biol

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“…While not parcellated into distinct regions, the dentate gyrus is one of the few regions of the adult brain to maintain neurogenesis throughout much of the adult life of mammals (Kempermann, 2012). Adult hippocampal neurogenesis has been reported in the dentate gyrus of all mammalian species studied to date (Cavegn et al, 2013;Chawana et al, 2014;Fasemore et al, 2018;Kempermann, 2012;Patzke et al, , 2015 to the exception of cetaceans, where this neural trait appears to be absent (Patzke et al, 2015). The six-layered subicular complex is composed of four parts, the dorsal and ventral subiculum, presubiculum, parasubiculum, and subicular transitional cortex, while the six-layered entorhinal cortex is most often described as being composed of medial and lateral cortical areas, but detailed analyses indicate the presence of several more cortical areas in this region Paxinos & Watson, 2009;Schulz & Engelhardt, 2014).…”

Section: Introductionmentioning

confidence: 99%

The brain of the tree pangolin (Manis tricuspis). IV. The hippocampal formation

Imam

Bhagwandin

Ajao

et al. 2019

J of Comparative Neurology

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Employing a range of standard and immunohistochemical stains we provide a description of the hippocampal formation in the brain of the tree pangolin. For the most part, the architecture, chemical neuroanatomy, and topological relationships of the component parts of the hippocampal formation of the tree pangolin were consistent with that observed in other mammalian species. Within the hippocampus proper fields CA1, 3, and 4 could be identified with certainty, while CA2 was tentatively identified as a small transitional zone between the CA1 and CA3 fields. Within the dentate gyrus evidence for adult hippocampal neurogenesis at a rate comparable to other mammals was observed. The subicular complex and entorhinal cortex also exhibited divisions typically observed in other mammalian species. In contrast to many other mammals, an architecturally and neurochemically distinct CA4 field was observed, supporting Lorente de Nó's proposed CA4 field, at least in some mammalian species. In addition, up to seven laminae were evident in the dentate gyrus. Calretinin immunostaining revealed the three sublamina of the molecular layer, while immunostaining for vesicular glutamate transporter 2 and neurofilament H indicate that the granule cell layer was composed of two sublamina. The similarities and differences observed in the tree pangolin indicate that the hippocampal formation is an anatomically and neurochemically conserved neural unit in mammalian evolution, but minor changes may relate to specific life history features and habits of species.

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“…Consequently, adult-born neurons are detected in the hypothalamus of several mammals including sheep, mouse, rats, vole, and hamster (Fowler et al, 2005; Xu et al, 2005; Pierce and Xu, 2010; Migaud et al, 2011; Mohr and Sisk, 2013; Robins et al, 2013; Batailler et al, 2014), suggesting that hypothalamic neurogenesis is a conserved process in mammals. Meanwhile, microchiropterans were previously reported to undergo no adult hippocampal neurogenesis (Amrein et al, 2007), later studies reported otherwise with significant expression of DCX detected via immunohistochemistry (Chawana et al, 2014). …”

Section: Introductionmentioning

confidence: 99%

Distinct Features of Doublecortin as a Marker of Neuronal Migration and Its Implications in Cancer Cell Mobility

Ayanlaja

Xiong

Gao

et al. 2017

Front. Mol. Neurosci.

107

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Neuronal migration is a critical process in the development of the nervous system. Defects in the migration of the neurons are associated with diseases like lissencephaly, subcortical band heterotopia (SBH), and pachygyria. Doublecortin (DCX) is an essential factor in neurogenesis and mutations in this protein impairs neuronal migration leading to several pathological conditions. Although, DCX is capable of modulating and stabilizing microtubules (MTs) to ensure effective migration, the mechanisms involved in executing these functions remain poorly understood. Meanwhile, there are existing gaps regarding the processes that underlie tumor initiation and progression into cancer as well as the ability to migrate and invade normal cells. Several studies suggest that DCX is involved in cancer metastasis. Unstable interactions between DCX and MTs destabilizes cytoskeletal organization leading to disorganized movements of cells, a process which may be implicated in the uncontrolled migration of cancer cells. However, the underlying mechanism is complex and require further clarification. Therefore, exploring the importance and features known up to date about this molecule will broaden our understanding and shed light on potential therapeutic approaches for the associated neurological diseases. This review summarizes current knowledge about DCX, its features, functions, and relationships with other proteins. We also present an overview of its role in cancer cells and highlight the importance of studying its gene mutations.

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Microbats appear to have adult hippocampal neurogenesis, but post-capture stress causes a rapid decline in the number of neurons expressing doublecortin

Cited by 25 publications

References 42 publications

Adult Hippocampal Neurogenesis in Natural Populations of Mammals

Adult Hippocampal Neurogenesis in Natural Populations of Mammals

The brain of the tree pangolin (Manis tricuspis). IV. The hippocampal formation

Distinct Features of Doublecortin as a Marker of Neuronal Migration and Its Implications in Cancer Cell Mobility

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