Microbes are off the menu: Defective macrophage phagocytosis in COPD

Walton, Emma Louise

doi:10.1016/j.bj.2017.12.002

Cited by 4 publications

(1 citation statement)

References 19 publications

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“…The Mycobacterium infection impairs phagolysosome maturation and leads to granuloma formation in infected macrophages [ 91 ]. Despite a significant increase in the number of macrophages in the lungs of patients with COPD, deficiencies in bacterial phagocytic activity have been associated with increased colonization by bacteria such as Haemophilus influenzae , S. pneumoniae , and Moraxella catarrhalis [ 124 ]. Similarly, patients with COPD are highly susceptible to exacerbations triggered by bacterial colonization as well as viral and bacterial respiratory infections [ 125 ].…”

Section: Role Of Macrophages and Their Polarization In Copdmentioning

confidence: 99%

Macrophage Polarization and Functions in Pathogenesis of Chronic Obstructive Pulmonary Disease

Kim,

Lim,

Shin

2024

IJMS

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Chronic obstructive pulmonary disease (COPD), the major leading cause of mortality worldwide, is a progressive and irreversible respiratory condition characterized by peripheral airway and lung parenchymal inflammation, accompanied by fibrosis, emphysema, and airflow limitation, and has multiple etiologies, including genetic variance, air pollution, and repetitive exposure to harmful substances. However, the precise mechanisms underlying the pathogenesis of COPD have not been identified. Recent multiomics-based evidence suggests that the plasticity of alveolar macrophages contributes to the onset and progression of COPD through the coordinated modulation of numerous transcription factors. Therefore, this review focuses on understanding the mechanisms and functions of macrophage polarization that regulate lung homeostasis in COPD. These findings may provide a better insight into the distinct role of macrophages in COPD pathogenesis and perspective for developing novel therapeutic strategies targeting macrophage polarization.

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Section: Role Of Macrophages and Their Polarization In Copdmentioning

confidence: 99%