Microbes versus microbes: immune signals generated by probiotic lactobacilli and their role in protection against microbial pathogens

Cross, M

doi:10.1016/s0928-8244(02)00377-2

Cited by 77 publications

(86 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Lactic acid bacteria are well recognized to polarize (strain specifically) host immune status (Cross 2002;Jood et al 2011). The metabolites produced by the action of probiotics on milk constituents also possess immuno-stimulating potentials (Cavallo et al 1996).…”

Section: Introductionmentioning

confidence: 99%

Dahi containing Lactobacillus acidophilus and Bifidobacterium bifidum improves phagocytic potential of macrophages in aged mice

Kaushal

Kansal

2012

J Food Sci Technol

View full text Add to dashboard Cite

The present study investigated the effect of Dahi containing potential probiotic bacterial strains on macrophage functions in ageing mice. Probiotic Dahi was prepared by co-culturing Dahi bacteria (Lactococcus lactis ssp. cremoris and Lactococcus lactis ssp. lactis biovar diacetylactis) along with Lactobacillus acidophilus LaVK2 (La-Dahi) or combined L. acidophilus LaVK2 and Bifidobacterium bifidum BbVK3 (LaBb-Dahi) in buffalo milk. The effect of ageing on phagocytic function was evaluated on 4 mo, 12 mo and 16 mo old mice. The effect of probiotic Dahi was evaluated for macrophage functions in ageing mice (12 mo old) fed La-Dahi or LaBb-Dahi supplements for 4 months. The production of extracellular superoxide and H 2 O 2 declined in peritoneal macrophages but enhanced in splenic macrophages, while intracellular superoxide declined in both peritoneal and splenic macrophages with ageing in mice. A decline in phagocytic activity of peritoneal macrophages was also observed in aged mice. Supplementation of diet with La-Dahi or LaBb-Dahi for 4 months improved production of reactive oxygen species and phagocytic and adherence indices of peritoneal macrophages in aged mice. These results suggest that oral administration of La-Dahi or LaBb-Dahi has potential to improve immune functions in ageing individuals.

show abstract

Section: Introductionmentioning

confidence: 99%

Dahi containing Lactobacillus acidophilus and Bifidobacterium bifidum improves phagocytic potential of macrophages in aged mice

Kaushal

Kansal

2012

J Food Sci Technol

View full text Add to dashboard Cite

show abstract

“…Recently the application of live bacteria as a potential mastitis therapeutic has gained interest. Probiotic bacteria can be used to control several infectious inflammatory and immunologic conditions through antagonism and immunomodulation (Cross, 2002). Commensal bacteria, with a broad spectrum of antimicrobial activity, have previously been isolated from healthy bovine udders and suggested as potential anti-mastitis agents (Al-Qumber & Tagg, 2006).…”

mentioning

confidence: 99%

Administration of a live culture ofLactococcus lactisDPC 3147 into the bovine mammary gland stimulates the local host immune response, particularlyIL-1β andIL-8gene expression

Beecher

Daly

Berry

et al. 2009

Journal of Dairy Research

View full text Add to dashboard Cite

Mastitis is one of the most costly diseases to the dairy farming industry. Conventional antibiotic therapy is often unsatisfactory for successful treatment of mastitis and alternative treatments are continually under investigation. We have previously demonstrated, in two separate field trials, that a probiotic culture, Lactococcus lactis DPC 3147, was comparable to antibiotic therapy to treat bovine mastitis. To understand the mode of action of this therapeutic, we looked at the detailed immune response of the host to delivery of this live strain directly into the mammary gland of six healthy dairy cows. All animals elicited signs of udder inflammation 7 h post infusion. At this time, clots were visible in the milk of all animals in the investigation. The most pronounced increase in immune gene expression was observed in Interleukin (IL)-1b and IL-8, with highest expression corresponding to peaks in somatic cell count. Infusion with a live culture of a Lc. lactis leads to a rapid and considerable innate immune response.

show abstract

“…According to Macdonald and Bell (2010), the influence of probiotic supplementation on immune response can be determined by the specific antibody levels in serum after vaccination, which correlates directly with the protection of the individual. This increase in antibody titers of groups supplemented with probiotics can be explained by a stimulatory effect on the immune system (ESPARZA; FRAGOSO, 2012;NOGUEIRA;GONÇALVES, 2011) that is attributable to lactic acid bacteria (CROSS, 2002;REIS, 2008), which were present in this study (Lactobacillus and Bifidobacterium). The bacteria in question potentiate vaccines via modulatory influences on the immune response such as increasing the production of antibodies and activating macrophages, T-cell proliferation and interferon production (ROOS, 2006).…”

Section: Frequency Of Cattle With Titers Of Antirabies Antibodiesmentioning

confidence: 51%

Efeito da concentração de bactérias probióticas como imunomodulador da produção de anticorpos antirrábicos em bovinos vacinados

et al. 2016

View full text Add to dashboard Cite

This study evaluated the effects of supplementation with a combination of probiotic microorganisms, added at different concentrations to the mineral mixture, on the production of serum antibodies against rabies virus in cattle vaccinated with a single dose of rabies vaccine. Forty-two male Nellore cattle, aged 12 months, were randomly divided into three groups (n = 14): the control group (CG) received 70 grams of mineral mixture/animal/day; and the 2 gram probiotic group (G2P) and 8 gram probiotic group (G8P) received 70 grams of mineral mix/animal/day with 2 and 8 grams added, respectively, of a combination of probiotic microorganisms (Lactobacillus acidophilus, Streptococcus faecium, Bifidobacterium thermophilum and Bifidobacterium longum). Individual antibody titers were determined using a neutralization in cell-based rapid fluorescent focus inhibition test (RFFIT) technique. One-way analysis of variance (one-way ANOVA) was used with contrasts using the Tukey method to determine whether the experimental groups differed within each time point, and the paired t-test was used to determine whether differences occurred between time points within each group. The level of significance was set at 5%. There were statistically significant differences between the mean serum concentrations of the CG and G8P groups at 30 and 60 days after the first vaccination, and at 60 days, 100% of the animals maintained minimum titers of protective antibodies only in the G8P group. There was also improvement in the production of antibodies in the G2P group compared with the CG after 30 and 60 days, but this difference was not statistically significant. In conclusion, increasing doses of probiotic added to the mineral mix beneficially affected the rabies humoral immune response, as determined by serum antibodies, and enabled the maintenance of minimum protective titers for a longer period in previously vaccinated cattle. ResumoEsse estudo avaliou o efeito da suplementação de uma associação de microrganismos probióticos, adicionados à mistura mineral em diferentes doses, na produção de anticorpos séricos antirrábicos em bovinos primovacinados. Quarenta e dois bovinos Nelore machos, com idade de 12 meses, foram divididos em três grupos (n=14): grupo controle (GC) recebeu 70 gramas de mistura mineral/animal/dia; grupos probiótico 2 gramas (G2P) e 8 gramas (G8P) receberam 70 gramas de mistura mineral/animal/dia adicionados respectivamente de 2 e 8 gramas de probióticos (Lactobacillus acidophilus, Streptococcus faecium, Bifidobacterium thermophilum e Bifidobacterium longum). Os títulos individuais de anticorpos antirrábicos foram determinados por meio da técnica de soroneutralização em células baseado no rapid fluorescent focus inhibition test (RFFIT). Os resultados obtidos foram comparados pelo teste t não pareado, com 5% de nível de significância. Houve diferenças estatísticas significativas entre as médias de concentrações séricas entre os grupos GC e G8P, após 30 e 60 dias da primovacinação e após 60 dias, somente o G8P manteve...

show abstract

Microbes versus microbes: immune signals generated by probiotic lactobacilli and their role in protection against microbial pathogens

Cited by 77 publications

References 44 publications

Dahi containing Lactobacillus acidophilus and Bifidobacterium bifidum improves phagocytic potential of macrophages in aged mice

Dahi containing Lactobacillus acidophilus and Bifidobacterium bifidum improves phagocytic potential of macrophages in aged mice

Administration of a live culture ofLactococcus lactisDPC 3147 into the bovine mammary gland stimulates the local host immune response, particularlyIL-1β andIL-8gene expression

Efeito da concentração de bactérias probióticas como imunomodulador da produção de anticorpos antirrábicos em bovinos vacinados

Contact Info

Product

Resources

About