Microbial Biofilms in Endodontic Infections: An Update Review

Mohammadi, Zahed; Palazzi, Flavio; Giardino, Luciano; Shalavi, Sousan

doi:10.4103/2319-4170.110400

Cited by 54 publications

(53 citation statements)

References 85 publications

(121 reference statements)

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“…The main challenges to the immune system are: recognizing the reabsorption. 28 It has been demonstrated that LPS also induces the expression of the adhesion molecules of leukocytes in endothelial cells and stimulates osteoclast differentiation and bone resorption, particularly through interactions with the receptor TLR-4 in cells of osteoblastic lineage 3 .…”

Section: Role Of Lps Binding Protein (Lbp) and The Cd14 Receptor In Cmentioning

confidence: 99%

“…After the development of aerobic and facultative anaerobic bacteria, a polymicrobial infection sets inside the root canal, where, with time, the Gramnegative and anaerobic species predominate 1,3 .…”

Section: Etiology Of Periapical Lesions and The Role Of Endotoxin In mentioning

confidence: 99%

“…The complex cascade of events associated with the tissue destruction and repair mediated by inflammatory response is still a subject of great interest and has been the focus of many research studies. 12,19 Gram-negative microorganisms, in addition to having different virulence factors and generating products and by-products toxic to the periapical tissues, contain endotoxin in their cell wall 3,[20][21][22] . This knowledge is In more detail, the metabolism cycle of the arachidonic acid can be explained as follows: phospholipase A 2 is present in the cell membrane and remains inhibited through annexins (annexin 1).…”

Section: Etiology Of Periapical Lesions and The Role Of Endotoxin In mentioning

confidence: 99%

“…When free to act, the molecules of endotoxin do not cause cell or tissue injuries directly, but stimulate competent cells to release biochemical mediators. Studies have demonstrated that macrophages are the main means of activation of LPS 3 . According to Leonardo et al 16 , the effects of endotoxin depends on the response of the host, whose oppressive, uncontrolled, and destructive behavior is what makes it biologically harmful.…”

Section: Introductionmentioning

confidence: 99%

“…This made it possible to identify the predominant microbiota in cases of teeth with and without chronic periapical reactions [2][3] .…”

Section: Introductionmentioning

confidence: 99%

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Role of endotoxin in the etiology of periapical lesions: molecular mechanisms involved in endotoxin's recognition and cell activation

Lucisano

Filho

Silva

et al. 2014

RGO, Rev. Gaúch. Odontol.

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Periapical lesions are diseases resulting from contamination and necrosis of dental pulp and the progression of this infection toward the periapical tissues. Technological advances in microbiological culture and identification have shown that anaerobic microorganisms, especially Gram-negative, are RESUMOAs lesões periapicais são patologias resultantes da contaminação e necrose da polpa dental e progressão da infecção em direção aos tecidos periapicais. Os avanços tecnológicos na cultura e identificação microbiana demonstraram que, em canais radiculares de dentes portadores de necrose pulpar e lesão periapical crônica, predominam os microrganismos anaeróbios, particularmente os Gram-negativos. As bactérias Gram-negativas, além de possuírem diferentes fatores de virulência e gerarem produtos e subprodutos tóxicos aos tecidos apicais e periapicais, contêm a endotoxina em sua parede celular. Esse conhecimento é importante, uma vez que a endotoxina é liberada durante a multiplicação ou morte bacteriana, exercendo uma série de efeitos biológicos relevantes, que conduzem a uma reação inflamatória e à reabsorção dos tecidos mineralizados. Sendo assim, o objetivo deste trabalho foi efetuar uma revisão da literatura relativa ao papel da endotoxina bacteriana na etiologia das lesões periapicais, seu mecanismo de ação, bem como elucidar mecanismos moleculares envolvidos no seu reconhecimento pelo sistema imunológico e na ativação celular. Role of endotoxin in the etiology of periapical lesions: molecular mechanisms involved in endotoxin's recognition and cell activationPapel da endotoxina na etiologia da lesão periapical: mecanismos moleculares envolvidos no seu reconhecimento e na ativação celular

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Section: Role Of Lps Binding Protein (Lbp) and The Cd14 Receptor In Cmentioning

confidence: 99%

Section: Etiology Of Periapical Lesions and The Role Of Endotoxin In mentioning

confidence: 99%