Microbial community changes in a female rat model of Rett syndrome

Gallucci, Allison; Patterson, Kelsey; Weit, Abigael R.; Pol, William J. Van Der; Dubois, Laura G.; Percy, Alan K.; Morrow, Casey D.; Campbell, Susan L.; Olsen, Michelle L.

doi:10.1016/j.pnpbp.2021.110259

Cited by 11 publications

(8 citation statements)

References 48 publications

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“… 75 Similarly, the abundance of Oscillospira in male and female ASD rodent models exhibited substantial differences, and these differences may be due to sex specificity. 71 , 72 Xi et al found that the abundance of Oscillospira in the gut of specific-pathogen-free chickens decreased with increasing age. 74 Maron et al found that Oscillospira was commonly found in the gut of older calves compared to younger calves.…”

Section: Factors Affecting the Abundance Of Oscillospiramentioning

confidence: 99%

Oscillospira - a candidate for the next-generation probiotics

et al. 2021

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Oscillospira is a class of organism that often appears in high-throughput sequencing data but has not been purely cultured and is widely present in the animal and human intestines. There is a strong association between variation in Oscillospira abundance and obesity, leanness, and human health. In addition, a growing body of studies has shown that Oscillospira is also implicated in other diseases, such as gallstones and chronic constipation, and has shown some correlation with the positive or negative changes in its course. Sequencing data combined with metabolic profiling indicate that Oscillospira is likely to be a genus capable of producing short-chain fatty acids (SCFAs) such as butyrate, which is an important reference indicator for screening “next-generation probiotics “. Considering the positive effects of Oscillospira in some specific diseases, such as obesity-related metabolic diseases, it has already been characterized as one of the next-generation probiotic candidates and therefore has great potential for development and application in the future food, health care, and biopharmaceutical products.

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Section: Factors Affecting the Abundance Of Oscillospiramentioning

confidence: 99%

Oscillospira - a candidate for the next-generation probiotics

et al. 2021

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“…Even though mechanisms are not clearly understood yet, altered gut microbiota could be implicated in the GI pathophysiology of RTT. To resolve this question, intestinal microbiota was investigated in a female rat model of RTT 38 , and different abundance of microbial taxa between wild-type (WT) and RTT rat has been identified. The use of animal models allows experimental control of the diet and the host, and manipulation of the microbiota is necessary to further investigate the role of the gut microbiome in the severity and progression of RTT.…”

Section: Digestive Systemmentioning

confidence: 99%

Rett syndrome: think outside the (skull) box

Borloz¹,

Villard²,

Roux³

2021

Fac Rev

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Rett syndrome (RTT) is a severe X-linked neurodevelopmental disorder characterized by neurodevelopmental regression between 6 and 18 months of life and associated with multi-system comorbidities. Caused mainly by pathogenic variants in the MECP2 (methyl CpG binding protein 2) gene, it is the second leading genetic cause of intellectual disability in girls after Down syndrome. RTT affects not only neurological function but also a wide array of non-neurological organs. RTT-related disorders involve abnormalities of the respiratory, cardiovascular, digestive, metabolic, skeletal, endocrine, muscular, and urinary systems and immune response. Here, we review the different aspects of RTT affecting the main peripheral groups of organs and sometimes occurring independently of nervous system defects.

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“…Similarly, a previous study in Shank3 KO mice reported a significantly different gastrointestinal morphology and altered microbial composition 41 . A recent study in RTT mice also reported alteration of gut microbiome across postnatal development as behavioral symptoms appear and progress 42 . Together, the extensive observation of gut microbial remodeling in clinical patients and preclinical models sheds an additional layer of insights into neuropsychiatric diseases and genetic underpinnings ( Figure 1 ).…”

Section: Gut Dysfunction and Dysbiosis In Neuropsychiatric Diseasesmentioning

confidence: 90%

Gut microbiome at the crossroad of genetic variants and behavior disorders

Cheng

Chen

et al. 2023

Gut Microbes

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Genetic variants are traditionally known to shape the susceptibility to neuropsychiatric disorders. An increasing number of studies indicate that remodeling of the gut microbiome by genetic variance serves as a versatile regulator of gut-brain crosstalk and behavior. Evidence also emerges that certain behavioral symptoms are specifically attributed to gut microbial remodeling and gut-to-brain signals, which necessitates rethinking of neuropsychiatric disease etiology and treatment from a systems perspective of reciprocal gene-microbe interactions. Here, we present an emerging picture of how gut microbes and host genetics interactively shape complex psychiatric phenotypes. We illustrate the growing understanding of how the gut microbiome is shaped by genetic changes and its connection to behavioral outcome. We also discuss working strategies and open questions in translating associative gene-microbiome-behavior findings into causal links and novel targets for neurobehavioral disorders. Dual targeting of the genetic and microbial factors may expand the space of drug discovery for neuropsychiatric diseases.

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Microbial community changes in a female rat model of Rett syndrome

Cited by 11 publications

References 48 publications

Oscillospira - a candidate for the next-generation probiotics

Oscillospira - a candidate for the next-generation probiotics

Rett syndrome: think outside the (skull) box

Gut microbiome at the crossroad of genetic variants and behavior disorders

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