Microbial contamination of hydrogel contact lenses

Gopinathan, Usha; Stapleton, Fiona; Sharma, Savitri; Willcox, Mark; Sweeney, Deborah F.; Rao, Girish; Ba, Holden

doi:10.1111/j.1365-2672.1997.tb03598.x

Cited by 55 publications

(16 citation statements)

References 17 publications

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“…Estudos mostram que grande parte das contaminações das LC ocorre após o contato com as mãos dos usuários (10)(11) . Assim, torna-se importante a higiene das mãos e o uso adequado das soluções para desinfecção das LC.…”

Section: Resumo Introduçãounclassified

Avaliação da ação antimicrobiana de soluções multiuso para desinfecção de lentes de contato hidrofílicas, in vitro

Lui¹,

Netto²,

Silva³

et al. 2009

Arq. Bras. Oftalmol.

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Section: Resumo Introduçãounclassified

Avaliação da ação antimicrobiana de soluções multiuso para desinfecção de lentes de contato hidrofílicas, in vitro

Lui¹,

Netto²,

Silva³

et al. 2009

Arq. Bras. Oftalmol.

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“…It is therefore obvious that there are controversies about the effect of soft contact lenses on ocular microbiota and the associated diseases. Many authors reported that asymptomatic lens wear for extended periods did increase ocular microbiota (Larkin et al, 1991;Hart et al, 1993) and others reported that asymptomatic lens worn for extended periods did not increase normal ocular microbiota (Gopinathan et al, 1997;Willcox et al, 1997). However, Efron et al (2005) suggested that ocular diseases of contact lens wearer could be as a result of noncompliance or omission of surfactant cleaning rub and rinse steps, the use of disinfecting solution of marginal efficacy and lenses that attract and rapidly deposit protein.…”

Section: Discussionmentioning

confidence: 95%

Bacteria isolated from contact and non contact lens and antibiotic susceptibility patterns of isolated Pseudomonas aeruginosa

Al-Zahrani¹

2012

Afr. J. Microbiol. Res.

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The aim of this study was to investigate the prevalence and type of microbial contamination, associated with contact lenses and lens care accessories used by a group of contact lens wearers. Results show that a total of 178 strains were isolated, including, 100 Gram positive and 78 Gram negative bacteria. Staphylococcus epidermidis and Pseudomonas aeruginosa were the most common microorganisms isolated (25.281 and 13.483% respectively. 24 P. aeruginosa were isolated from lenses and eyes of contact lens and non-contact lens wearers. All isolates were susceptible to the tested aminoglycosides and fluoroquinolones. Aminoglycosides and fluoroquinolones (ciprofloxacin) were more efficient than β-lactams. 91.67% of the strains had intermediate-resistant to cefotaximee; 4.17% were resistant and 4.17% were sensitive to Cefotaximee. 95.83% of the strains were sensitive, while 4.17% were resistant to Imipenem. 20.83 and 12.5% of P. aeruginosa strains were resistant and sensitive to Ceftriaxone respectively, while 66.67% were moderately-resistant to ceftriaxone of the β-lactam class. All isolates were sensitive to the other tested β-lactam.

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“…There was no increase in frequency of contamination or numbers of bacteria during that time period, with the exception of Propionibacterium sp in which the frequency of colonization increased at the 2-year visit. Furthermore, Gopinathan et al 53 followed up 50 patients wearing low Dk disposable lenses for EW over 18 months and also found no difference in lens contamination with time. Alternatively, some studies have assessed the effect of lens age as opposed to patient-years of experience on microbial bioburden of worn CLs.…”

Section: Bioburdenmentioning

confidence: 99%

Microbial Contamination of Contact Lenses, Lens Care Solutions, and Their Accessories: A Literature Review

Szczotka-Flynn

Pearlman

Ghannoum

2010

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

210

155

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Purpose A contact lens (CL) can act as a vector for microorganisms to adhere to and transfer to the ocular surface. Commensal microorganisms that uneventfully cohabitate on lid margins and conjunctivae and potential pathogens that are found transiently on the ocular surface can inoculate CLs in vivo. In the presence of reduced tissue resistance, these resident microorganisms or transient pathogens can invade and colonize the cornea or conjunctiva to produce inflammation or infection. Methods The literature was reviewed and used to summarize the findings over the last 30 years on the identification, enumeration, and classification of microorganisms adherent to CLs and their accessories during the course of normal wear and to hypothesize the role that these microorganisms play in CL infection and inflammation. Results Lens handling greatly increases the incidence of lens contamination, and the ocular surface has a tremendous ability to destroy organisms. However, even when removed aseptically from the eye, more than half of lenses are found to harbor microorganisms, almost exclusively bacteria. Coagulase-negative Staphylococci are most commonly cultured from worn lenses; however, approximately 10% of lenses harbor Gram-negative and highly pathogenic species, even in asymptomatic subjects. In storage cases, the incidence of positive microbial bioburden is also typically greater than 50%. All types of care solutions can become contaminated, including up to 30% of preserved products. Conclusions The process of CL-related microbial keratitis and inflammation is thought to be preceded by the presence or transfer or both of microorganisms from the lens to the ocular surface. Thus, this detailed understanding of lens-related bioburden is important in the understanding of factors associated with infectious and inflammatory complications. Promising mechanisms to prevent bacterial colonization on lenses and lens cases are forthcoming, which may decrease the incidence of microbially driven CL complications.

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Microbial contamination of hydrogel contact lenses

Cited by 55 publications

References 17 publications

Avaliação da ação antimicrobiana de soluções multiuso para desinfecção de lentes de contato hidrofílicas, in vitro

Avaliação da ação antimicrobiana de soluções multiuso para desinfecção de lentes de contato hidrofílicas, in vitro

Bacteria isolated from contact and non contact lens and antibiotic susceptibility patterns of isolated Pseudomonas aeruginosa

Microbial Contamination of Contact Lenses, Lens Care Solutions, and Their Accessories: A Literature Review

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