Microbial exopolysaccharide-based nano-carriers with unique multi-functionalities for biomedical sectors

Asgher, Muhammad; Qamar, Sarmad Ahmad; Iqbal, Hafiz M.N.

doi:10.2478/s11756-020-00588-7

Cited by 29 publications

(23 citation statements)

References 104 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The nuclear magnetic resonance (NMR) analysis of purified EPS was performed using a 5 mm reverse probe Bruker AVANCE 400 MHz NMR spectrometer. The EPS was dissolved in deuterium oxide (D 2 O) at 10 mg mL −1 concentration and 1 H NMR and 13 C NMR spectra were measured. The NMR data were processed using Bruker TopSpin software (Waltham, MA, USA).…”

Section: Nmr and Sem Analysismentioning

confidence: 99%

“…Another doublet was found at 5.14 ppm identified as α-D-Mannopyranose (α-D-Manp) which contains the linkage at its 2nd and/or 6th position [70,71]. 13 C NMR spectra displayed NMR peaks in the range from 57.85 ppm to 104.18 ppm (Figure 6). The characteristic anomeric peak at 104.18 ppm was identified as anomeric C1 signal of β-D-Galp which should be a terminal β-D-Galp [72].…”

Section: H and 13 C Nmr Spectra Interpretation Of Epsmentioning

confidence: 99%

“…In addition to controlled drug administration in EPS, potential applications include vaccines, adjuvants and diagnostic imaging systems [ 13 ]. In commercial pharmaceuticals and medical devices, many potential applications are expected to be developed.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Structural Characterisation and Assessment of the Novel Bacillus amyloliquefaciens RK3 Exopolysaccharide on the Improvement of Cognitive Function in Alzheimer’s Disease Mice

et al. 2021

View full text Add to dashboard Cite

In this study Bacillus amyloliquefaciens RK3 was isolated from a sugar mill effluent-contaminated soil and utilised to generate a potential polysaccharide with anti-Alzheimer’s activity. Traditional and molecular methods were used to validate the strain. The polysaccharide produced by B. amyloliquefaciens RK3 was purified, and the yield was estimated to be 10.35 gL−1. Following purification, the polysaccharide was structurally and chemically analysed. The structural analysis revealed the polysaccharide consists of α-d-mannopyranose (α-d-Manp) and β-d-galactopyranose (β-d-Galp) monosaccharide units connected through glycosidic linkages (i.e, β-d-Galp(1→6)β-d-Galp (1→6)β-d-Galp(1→2)β-d-Galp(1→2)[β-d-Galp(1→6)]β-d-Galp(1→2)α-d-Manp(1→6)α-d-Manp (1→6)α-d-Manp(1→6)α-d-Manp(1→6)α-d-Manp). The scanning electron microscopy and energy-dispersive X-ray spectroscopy imaging of polysaccharides emphasise their compactness and branching in the usual tubular heteropolysaccharide structure. The purified exopolysaccharide significantly impacted the plaques formed by the amyloid proteins during Alzheimer’s disease. Further, the results also highlighted the potential applicability of exopolysaccharide in various industrial and pharmaceutical applications.

show abstract

Section: Nmr and Sem Analysismentioning

confidence: 99%

Section: H and 13 C Nmr Spectra Interpretation Of Epsmentioning

confidence: 99%

See 1 more Smart Citation

Structural Characterisation and Assessment of the Novel Bacillus amyloliquefaciens RK3 Exopolysaccharide on the Improvement of Cognitive Function in Alzheimer’s Disease Mice

et al. 2021

View full text Add to dashboard Cite

show abstract

“…[ 7,8 ] Nanosystem‐based methodologies for biomedical and pharmaceutical applications have explicitly raised high expectations. [ 9 ] Nanosystem possess various attractive properties and are not restricted to define the ineffective solubility of drug in aqueous media, the bioavailability of drug molecules during both blood circulation and storage, and the retention time of drug according to dynamic standards via active or passive target specifications. [ 9,10 ] Due to their biocompatible and biodegradable nature, and the presence of exceptional multifunctional groups, polysaccharide‐based nanoparticles have been considered as drug delivery vehicles for different medicinal agents.…”

Section: Introductionmentioning

confidence: 99%

“…[ 9,10 ] Due to their biocompatible and biodegradable nature, and the presence of exceptional multifunctional groups, polysaccharide‐based nanoparticles have been considered as drug delivery vehicles for different medicinal agents. [ 9,11 ]…”

Section: Introductionmentioning

confidence: 99%

Algal Polysaccharides‐Based Nanoparticles for Targeted Drug Delivery Applications

et al. 2022

Self Cite

View full text Add to dashboard Cite

A huge variety of polysaccharides can be obtained from algal biomass having several attractive properties such as cost‐effectiveness, non‐toxicity, biodegradability, abundant availability, and biocompatibility. In recent years, algal polysaccharides (including alginates, carrageenans, fucoidans, ulvans, and agaroses) have extensively been reported for their chemical properties and important bioactive potentialities. Furthermore, algal polysaccharides have gained huge scientific interest as they are a significant source of biologically active compounds, and they show various medical potentialities including anticancer, antiproliferative, anticoagulant, antitumoral, and antiviral properties. Exceptional physicochemical and biological characteristics make them interesting candidates for biotechnological and biomedical investigations. In this review, nanodrug delivery systems based on different algal‐polysaccharides (alginates, carrageenans, fucoidan, ulvan, and other) are described in a systematic way. Moreover, the current challenges and future prospects in the area of algal exploitation for biomedical applications are summarized at the end.

show abstract

Prospects of microbial polysaccharides‐based hybrid constructs for biomimicking applications

et al. 2022

Self Cite

View full text Add to dashboard Cite

Polysaccharides are biobased polymers obtained from renewable sources. They exhibit various interesting features including biocompatibility, biodegradability, and nontoxicity. Microbial polysaccharides are produced by several microorganisms including yeast, fungi, algae, and bacteria. Microbial polysaccharides have gained high importance in biotechnology due to their novel physiochemical characteristics and composition. Among microbial polysaccharides, xanthan, alginate, gellan, and dextran are the most commonly reported polysaccharides for the development of biomimetic materials for biomedical applications including targeted drug delivery, wound healing, and tissue engineering. Several chemical and physical cross‐linking reactions are performed to increase their technological and functional properties. Owning to the broad‐scale applications of microbial polysaccharides, this review aims to summarize the characteristics with different ways of physical/chemical crosslinking for polysaccharide regulation. Recently, several biopolymers have gained high importance due to their biologically active properties. This will help in the formation of bioactive nutraceuticals and functional foods. This review provides a perspective on microbial polysaccharides, with special emphasis given to applications in promising biosectors and the subsequent advancement on the discovery and development of new polysaccharides for adding new products.

show abstract

Microbial exopolysaccharide-based nano-carriers with unique multi-functionalities for biomedical sectors

Cited by 29 publications

References 104 publications

Structural Characterisation and Assessment of the Novel Bacillus amyloliquefaciens RK3 Exopolysaccharide on the Improvement of Cognitive Function in Alzheimer’s Disease Mice

Structural Characterisation and Assessment of the Novel Bacillus amyloliquefaciens RK3 Exopolysaccharide on the Improvement of Cognitive Function in Alzheimer’s Disease Mice

Algal Polysaccharides‐Based Nanoparticles for Targeted Drug Delivery Applications

Prospects of microbial polysaccharides‐based hybrid constructs for biomimicking applications

Contact Info

Product

Resources

About