Microbial growth and metabolism in house dust

Korpi, Anne; Pasanen, Anna‐Liisa; Pasanen, Pertti; Kalliokoski, Pentti

doi:10.1016/s0964-8305(97)00032-2

Cited by 77 publications

(73 citation statements)

References 27 publications

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“…However, the use of only one kind of medium for each fungal species (MEA or MEA15%) probably limited the MVOC emission. In fact, it is well-known how the production is strictly growth substrate-dependent (Matysik et al, 2009;Moularat et al, 2008) and several kinds of culture media, included contaminated building materials or settled dust samples, were generally included in the experiments (Korpi et al, 1997;Matysik et al, 2008;Vishwanath et al, 2011;Wady and Larsson, 2005;Wady et al, 2003;Wilkins et al, 2000). On the other hand, working with Cultural Heritage has often limitations and, because of the preciousness of the artefacts, most of the applied methods need to be non-invasive (Kostadinovska, 2015;Manente et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Detection of volatile metabolites of moulds isolated from a contaminated library

Micheluz

Manente

Rovea

et al. 2016

Journal of Microbiological Methods

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The principal fungal species isolated from a contaminated library environment were tested for their microbial volatile organic compound (MVOC) production ability. Aspergillus creber, A. penicillioides, Cladosporium cladosporioides, Eurotium chevalieri, E. halophilicum, Penicillium brevicompactum and P. chrysogenum were cultivated on suitable culture media inside sample bottles specifically designed and created for direct MVOC injection to a GC-MS instrument. The fungal emissions were monitored over several weeks to detect changes with the aging of the colonies, monitored also by respirometric tests. A total of 55 different MVOCs were detected and isopropyl alcohol, 3-methyl-1-butanol and 2-butanone were the principal compounds in common between the selected fungal species. Moreover, 2,4-dimethylheptane, 1,4-pentadiene, styrene, ethanol, 2-methyl-1-butanol, acetone, furan and 2-methylfuran were the most detected compounds. For the first time, the MVOC production for particular fungal species was detected. The species A. creber, which belongs to the recently revised group Aspergillus section Versicolores, was characterized by the production of ethanol, furan and 1,4-pentadiene. For the xerophilic fungus E. halophilicum, specific production of acetone, 2-butanone and 1,4-pentadiene was detected, supported also by respirometric data. The results demonstrated the potential use of this method for the detection of fungal contamination phenomena inside Cultural Heritage's preservation environments.

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Section: Discussionmentioning

confidence: 99%

Detection of volatile metabolites of moulds isolated from a contaminated library

Micheluz

Manente

Rovea

et al. 2016

Journal of Microbiological Methods

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“…produced by microorganisms as part of their metabolic processes; more than 200 compounds in this class have been discovered in chamber studies (Fiedler et al, 2001;Korpi et al, 1997;Pasanen et al, 1997;Scholler et al, 2002). MVOCs have been considered to be potential causative agents since Wessen and Schoeps (1996) reported having found 26 MVOCs whose concentrations were higher indoors than outdoors.…”

Section: Microbial Volatile Organic Compounds (Mvocs) Include a Rangementioning

confidence: 99%

The relationship between exposure to microbial volatile organic compound and allergy prevalence in single-family homes

Araki

Kanazawa

Kawai

et al. 2012

Science of The Total Environment

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Microbial volatile organic compounds (MVOCs) are a type of VOCs produced by microorganisms. Exposure to 1-octen-3-ol, one of the known MVOCs, has been reported to reduce nasal patency and increase nasal lavage myeloperoxidase, eosinophil cationic proteins, and lysozymes in both experimental and field studies. We reported in a previous paper that 1-octen-3-ol exposure at home is associated with mucosal symptoms. In this study, our aim was to investigate the relationship between asthma and allergies and MVOC exposure in single-family homes. The subjects were 624 inhabitants of 182 detached houses in six regions of Japan. Air samples were collected using diffusive samplers, and the concentrations of eight selected MVOCs were analyzed using gas chromatography/mass spectrometry in selected-ion-monitoring mode. Each inhabitant of each of the dwellings was given a self-administered questionnaire. Among the 609 subjects who answered all of the questions about allergies, history of the medical treatment for asthma, atopic dermatitis, allergic rhinitis, and allergic conjunctivitis within the past two years was 4.8%, 9.9%, 18.2%, and 7.1 %, respectively. A significant association between 1-octen-3-ol (per log 10 unit) and allergic rhinitis odds ratio (OR): 4.10, 95% confidence interval (CI): 1.71 to 9.80 and conjunctivitis (OR: 3.54, CI: 1.17 to 10.7) was found after adjusting for age, sex, environmental-tobacco-smoke exposure, wall-to-wall carpeting in the home, signs of dampness, history of treatment for hay fever, and other potentially relevant environmental factors. No relationships were found between any MVOCs and asthma or atopic dermatitis after the adjustment. The levels of MVOCs and airborne fungi were only weakly correlated. These results are consistent with previous studies that have associated higher levels of 1-octen-3-ol exposure with increased irritation of nasal 4 and ocular mucosae. Although the indoor-air concentrations of 1-octen-3-ol found in this study were relatively low, we conclude that exposure to MVOC may be related to rhinitis and conjunctivitis.

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“…3-Methylfuran and 1-octen-3-ol are commonly produced by mold (Borjesson et al, 1992;Borjesson et al, 1993;Korpi et al, 1997;Matysik et al, 2008). In human chamber studies, these compounds caused acute effects, such as objective and/or subjective signs of mild mucosal irritation of the eyes and airways due to exposure (Wålinder et al, 2005;Walinder et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Relationship between selected indoor volatile organic compounds, so-called microbial VOC, and the prevalence of mucous membrane symptoms in single family homes

Araki

Kawai

Eitaki

et al. 2010

Science of The Total Environment

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Abstract:Micro-organisms are known to produce a range of volatile organic compounds, so-called microbial VOC (MVOC). Chamber studies where humans were exposed to MVOC addressed the acute effects of objective and/or subjective signs of mucosal irritation. However, the effect of MVOC on inhabitants due to household exposure is still unclear. The purpose of this epidemiological study was to measure indoor MVOC levels in single family homes and to evaluate the relationship between exposure to them and sick building syndrome (SBS). All inhabitants of the dwellings were given a self-administered questionnaire with standardized questions to assess their symptoms.Air samples were collected and the concentrations of eight selected compounds in indoor air were analyzed by gas chromatography/mass spectrometry -selective ion monitoring mode (GC/MS-SIM). The most frequently detected MVOC was 1-pentanol at a detection rate of 78.6% and geometric mean of 0.60 μg/m 3 . Among 620 participants, 120 (19.4%) reported one or more mucous symptoms; irritation of the eyes, nose, airway, or coughing every week (weekly symptoms), and 30 (4.8%) reported that the symptoms were home-related (home-related symptoms). Weekly symptoms were not associated with any of MVOC, whereas significant associations between home-related mucous symptoms and 1-octen-3-ol (per log 10 -unit: odds ratio (OR) 5.6, 95% confidence interval (CI): 2.1 to 14.8) and 2-pentanol (per log 10 -unit: OR 2.3, 95%CI: 1.0 to 4.9) were obtained after adjustment for gender, age, and smoking.Associations between home-related symptoms and 1-octen-3-ol remained after mutual adjustment. However, concentrations of the selected compounds in indoors were lower than the estimated safety level in animal studies. Thus, the statistically significant association between 1-octen-3-ol may be due to a direct effect of the compounds or the associations may be being associated with other offending compounds. Additional studies are needed to evaluate these possibilities.

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Microbial growth and metabolism in house dust

Cited by 77 publications

References 27 publications

Detection of volatile metabolites of moulds isolated from a contaminated library

Detection of volatile metabolites of moulds isolated from a contaminated library

The relationship between exposure to microbial volatile organic compound and allergy prevalence in single-family homes

Relationship between selected indoor volatile organic compounds, so-called microbial VOC, and the prevalence of mucous membrane symptoms in single family homes

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