Microbial polymers as a degradable carrier for pesticide delivery

Voinova, O. N.; Калачева, Г. С.; Grodnitskaya, I. D.; Volova, Tatiana G.

doi:10.1134/s0003683809040061

Cited by 48 publications

(39 citation statements)

References 12 publications

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“…The aim of this work was to develop (involving preparation, characterization and evaluation of the release profile) a release system for the herbicide ametryn, using microparticles produced with two different polymers, PHB and PHBV, since these polymers are biodegradable and their degradation products are nontoxic to the environment [24]. The purpose of encapsulating ametryn in PHB or PHBV microparticles was to produce a modified release system that could enable the herbicide to be used more safely in agriculture, minimizing its environmental impact.…”

Section: Introductionmentioning

confidence: 99%

Controlled release system for ametryn using polymer microspheres: Preparation, characterization and release kinetics in water

Grillo

Pereira

Melo

et al. 2011

Journal of Hazardous Materials

122

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a b s t r a c tThe purpose of this work was to develop a modified release system for the herbicide ametryn by encapsulating the active substance in biodegradable polymer microparticles produced using the polymers poly(hydroxybutyrate) (PHB) or poly(hydroxybutyrate-valerate) (PHBV), in order to both improve the herbicidal action and reduce environmental toxicity. PHB or PHBV microparticles containing ametryn were prepared and the efficiencies of herbicide association and loading were evaluated, presenting similar values of approximately 40%. The microparticles were characterized by scanning electron microscopy (SEM), which showed that the average sizes of the PHB and PHBV microparticles were 5.92 ± 0.74 m and 5.63 ± 0.68 m, respectively. The ametryn release profile was modified when it was encapsulated in the microparticles, with slower and more sustained release compared to the release profile of pure ametryn. When ametryn was associated with the PHB and PHBV microparticles, the amount of herbicide released in the same period of time was significantly reduced, declining to 75% and 87%, respectively. For both types of microparticle (PHB and PHBV) the release of ametryn was by diffusion processes due to anomalous transport (governed by diffusion and relaxation of the polymer chains), which did not follow Fick's laws of diffusion. The results presented in this paper are promising, in view of the successful encapsulation of ametryn in PHB or PHBV polymer microparticles, and indications that this system may help reduce the impacts caused by the herbicide, making it an environmentally safer alternative.

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Section: Introductionmentioning

confidence: 99%

Controlled release system for ametryn using polymer microspheres: Preparation, characterization and release kinetics in water

Grillo

Pereira

Melo

et al. 2011

Journal of Hazardous Materials

122

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“…Voinova et al have investigated the possibility of use of PHAs as a biodegradable carrier for pesticides (α-hexachlorocyclohexane and lindane) for targeted and controlled delivery of these compounds to soil. According to their investigation, pesticides embedded in a PHA carrier are released gradually and slowly, without surges, as the polymer is degraded by the soil microflora (258).…”

Section: (2) Medical and Pharmaceutical Applicationsmentioning

confidence: 99%

Bacterial polyhydroxyalkanoates-eco-friendly next generation plastic: Production, biocompatibility, biodegradation, physical properties and applications

Muhammadi

Shabina

Afzal

et al. 2015

Green Chemistry Letters and Reviews

274

139

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Polyhydroxyalkanoates (PHAs) are intracellular aliphatic polyesters synthesized as energy reserves, in the form of water-insoluble, nano-sized discrete and optically dense granules in cytoplasm by a diverse bacteria and some archae under conditions of limiting nutrients in the presence of excess carbon source. Bacteria synthesize different PHAs from coenzyme A thioesters of respective hydroxyalkanoic acid, and degrade intracellularly for reuse and extracellularly in natural environments by other microorganisms. In vivo, PHAs exist as amorphous mobile liquid and water-insoluble inclusions but in vitro, exhibit material and mechanical properties, ranging from stiff and brittle crystalline to elastomeric and molding, similar to petrochemical thermoplastics. Further, they are hydrophobic, isotactic, biocompatible and exhibit piezoelectric properties. But as commodity plastics their applications are limited by high production cost, low yield, in vivo degradation, complexity of technology and difficulty of extraction. Therefore, to replace the conventional plastic with PHAs, it is prerequisite to standardize the PHA production systems.

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“…Whether they adhere or not is important because loss of applied pesticides from plant leaves leads to their repeated application and more off-target effects [28–29]. OCL filomicelles, short worms and spheres loaded with PCL-Rho were sprayed onto Broccoli leaves and Pinto bean leaves and later assessed for their survival after air drying for several hours.…”

Section: Resultsmentioning

confidence: 99%

Spray stability of self-assembled filaments for delivery

Mahmud

Harada

Rajagopal

et al. 2017

Journal of Controlled Release

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Filamentous viruses are common in nature and efficiently deliver – sometimes via aerosol – genetic material, viral proteins, and other factors to animals and plants. Aerosolization can be a severe physicochemical test of the stability of any filamentous assembly whether it is made from natural polymers such as viral proteins or synthetic polymers. Here, worm-like “filomicelles” that self-assemble in water from amphiphilic block copolymers were investigated as aerosolized delivery vehicles. After spraying and drying, fluorophore-loaded filomicelles that were originally ~10–20 μm long could be imaged as 2–5 μm long fragments that survived rehydration on natural and artificial surfaces (i.e. plant leaves and glass). As a functional test of delivery, the hydrophobic pesticide bifenthrin was loaded into filomicelles (up to 25% w/w) and sprayed onto plants infested with two agricultural pests, beet army worm or two-spotted spider mites; pesticidal efficacy exceeded that of commercial formulations. Persistent delivery by the filomicelle formulation was especially notable and broadly consistent with previous intravenous delivery of other drugs and dyes with the highly elongated filomicelles.

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Microbial polymers as a degradable carrier for pesticide delivery

Cited by 48 publications

References 12 publications

Controlled release system for ametryn using polymer microspheres: Preparation, characterization and release kinetics in water

Controlled release system for ametryn using polymer microspheres: Preparation, characterization and release kinetics in water

Bacterial polyhydroxyalkanoates-eco-friendly next generation plastic: Production, biocompatibility, biodegradation, physical properties and applications

Spray stability of self-assembled filaments for delivery

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