Microbial Polysaccharides as Advance Nanomaterials

Bhatia, Saurabh

doi:10.1007/978-3-319-41926-8_2

Cited by 7 publications

(3 citation statements)

References 77 publications

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“…59 Hydrogel nanoparticles of curdlan derivatives have shown potential in the delivery of anticancer drugs. 60 Because EPSs are bio-compatible and non-toxic, they offer more benefits in the green synthesis of silver nanoparticles compared to synthetic polymers. 61…”

Section: Nano-and Micro-delivery Systemsmentioning

confidence: 99%

“…72 Partial sulfation of curdlan at the O-6 portion improves the aqueous solubility of curdlan hydrogel nanoparticles; however, the extent of substitution affects the thermal stability and ability to cross-link with polycytidylic acid. 60,73 Exopolysaccharides are also combined with other polysaccharides, biopolymers or synthetic polymers to optimize desirable material characteristics of these polymers and improve upon their limitations. This combination results in polymer blends with high-performance characteristics capable of being tailored toward various novel drug delivery applications.…”

Section: Modifications To Improve Drug Deliverymentioning

confidence: 99%

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Drug delivery applications and future prospects of microbial exopolysaccharides

Adegbolagun,

Odeniyi,

Odeniyi

2023

Polim. Med.

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Over the years, exopolysaccharides (EPSs) have been utilized in various areas of research, including health, industry, environment, and agriculture, due to their flexible physical, chemical and structural properties that can be readily modified to suit desired purposes. Current research trends have shown that EPS production is dependent on numerous factors which can be combined to varying extent to optimize production yields. Although the majority of research is directed towards their industrial and medicinal uses, these chemical substances possess peculiar characteristics which are also exploited for biomedical research, where they are being used as drug delivery systems, some of which include their abundance in nature, biocompatibility, biodegradability, non-toxicity, and ability to efficiently encapsulate sensitive bioactive agents. However, despite the numerous beneficial prospects of microbial EPSs in drug delivery, there are limitations to the commercial production and industrial applications of these biopolymers. These limitations have inspired revolutionary research into the cost-effective production of safe EPSs polymers. In this review, we classify EPSs and discuss their methods of extraction and characterization. We also summarized current drug delivery applications and discussed limitations to extensive industrial commercialization of EPSs, while highlighting prospects for the utilization of microbial EPSs and implications for research.

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Section: Nano-and Micro-delivery Systemsmentioning

confidence: 99%

Section: Modifications To Improve Drug Deliverymentioning

confidence: 99%

Drug delivery applications and future prospects of microbial exopolysaccharides

Adegbolagun,

Odeniyi,

Odeniyi

2023

Polim. Med.

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“…Exopolysaccharides (EPSs) secreted out of microorganisms are sugar biopolymers consisting of homo- or hetero-saccharides that are linked together by glycosidic bonds to generate long linear or branched chains. The naturally occurring EPSs are abundant, readily available, biodegradable, and potentially non-toxic ( Moscovici, 2015 ; Bhatia, 2016 ). EPSs have found a vast range of applications in nanotechnology, like green synthesis of metal nanoparticles ( Kanmani and Lim, 2013 ; Sathiyanarayanan et al, 2017 ), hydrogel ( Na et al, 2000 ; Maiti et al, 2011 ; Koop et al, 2015 ), coating materials ( Jang et al, 2013 ; You et al, 2014 ; Bondarenko et al, 2016 ), stabilizers ( Dey et al, 2016 ), nanoparticles ( Wang et al, 2013 ; Guo et al, 2014 ; Zhang et al, 2016 ), capping agents ( Wu et al, 2012 ; Yan et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Exopolysaccharide-Derived Carbon Dots for Microbial Viability Assessment

Lin

Chen

2018

Front. Microbiol.

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Fluorescent dye staining combined with fluorescence microscopy or flow cytometry is becoming a routine way to monitor microorganism viability that is necessary for food safety, antibiotic development, and human health. However, the conventional live/dead assay dyes suffer from high cost, inconvenient staining steps, and high cytotoxicity, which is urgently needed to overcome. Herein, cheap carbon dots, CDs-EPS605, were reported to successfully assess microbial viability in a convenient way with neglectable cytotoxicity. The fluorescent N-doped CDs-EPS605 could be facilely prepared from bacterial amino exopolysaccharide (EPS) by one-step hydrothermal carbonization, which is cost-effective and sustainable. The negatively charged CDs-EPS605 consisted of C, H, O, N, P, and S, and featured various functional groups, including -COOH, -OH, -CONH-, and -NH2. CDs-EPS605 were observed to sensitively and selectively stain dead microorganisms instead of live ones to enable discrimination of live/dead microorganisms. The labeling method with CDs-EPS605 did not require protection from light, or washing, which is convenient. Additionally, CDs-EPS605 displayed better photostability and much less cytotoxicity compared to the commercial counterpart. Altogether, CDs-EPS605 represent a simple, yet powerful staining agent for microbial viability assessment, and at the same time enrich the current applications of microbial EPS.

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