Microbial production of flavonoids and terpenoids

Dvora, Hila; Koffas, Mattheos A. G.

doi:10.1533/9780857093547.2.234

Cited by 3 publications

(3 citation statements)

References 96 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also, cytochromes P450 rely on P450 reductase enzymes (CPR) for cofactor regeneration, which are not present in bacteria and therefore need to be co-introduced into production strains [36]. In contrast, conversion of L -tyrosine into p-coumaric acid occurs in a single step catalyzed by a tyrosine ammonia-lyase (TAL), circumventing the need for C4H activity.…”

Section: Microbial Production Of Plant Polyphenols: Past Achievementsmentioning

confidence: 99%

“…The advent of functional "Omics", genome-scale modeling, and high-throughput screening technologies, combined with the evergrowing genome engineering, editing, and (heterologous) gene expression toolbox, has brought metabolic engineering to a more systematic and global level, thus significantly reducing the costs associated with the complete development of a novel bioprocess. The variety and complexity of chemicals that can now be produced using microbial cell factories has remarkably increased allowing now even the production of complex polyphenols with multiple biosynthetic pathways steps [35,36].…”

mentioning

confidence: 99%

See 1 more Smart Citation

Engineering of Microbial Cell Factories for the Production of Plant Polyphenols with Health-Beneficial Properties

Dudnik

Gaspar

Neves

et al. 2018

CPD

View full text Add to dashboard Cite

Polyphenols form a group of important natural bioactive compounds with numerous ascribed healthbeneficial attributes (e.g. antioxidant, anti-inflammatory, anti-microbial and tumor-suppressing properties). Some polyphenols can also be used as natural dyes or plastic precursors. Notwithstanding their relevance, production of most of these compounds still relies on extraction from plant material, which for most of it is a costly and an inefficient procedure. The use of microbial cell factories for this purpose is an emerging alternative that could allow a more efficient and sustainable production. The most recent advances in molecular biology and genetic engineering, combined with the ever-growing understanding of microbial physiology have led to multiple success stories. Production of multiple polyphenolic compounds or their direct precursors has been achieved not only in the common production hosts, such as Escherichia coli and Saccharomyces cerevisiae, but also in Corynebacterium glutamicum and Lactococcus lactis. However, boosting production of native compounds or introduction of heterologous biosynthetic pathways also brings certain challenges, such as the need to express, balance and maintain efficient precursor supply. This review will discuss the most recent advances in the field of metabolic engineering of microorganisms for polyphenol biosynthesis and its future perspectives, as well as outlines their potential health benefits and current production methods.

show abstract

Section: Microbial Production Of Plant Polyphenols: Past Achievementsmentioning

confidence: 99%

mentioning

confidence: 99%

Engineering of Microbial Cell Factories for the Production of Plant Polyphenols with Health-Beneficial Properties

Dudnik

Gaspar

Neves

et al. 2018

CPD

View full text Add to dashboard Cite

show abstract

“…6, in plants the biosynthesis of the core intermediate of the phenylpropanoid pathway, p-coumaric acid, begins from L-phenylalanine and occurs in two steps: a deamination reaction catalyzed by phenylalanine ammonia-lyase (PAL) and a hydroxylation reaction catalyzed by cinnamate 4-hydroxylase (C4H). The latter enzyme belongs to the CYP family that is often challenging to express in active form in prokaryotic systems (Dvora and Koffas 2013). However, in some bacteria and fungi there exists an alternative pathway where L-tyrosine is converted directly into p-coumaric acid via the action of tyrosine ammonia-lyase (TAL), hence bypassing the C4H step (Fig.…”

Section: Lactococcus Lactismentioning

confidence: 99%

BacHBerry: BACterial Hosts for production of Bioactive phenolics from bERRY fruits

et al. 2017

View full text Add to dashboard Cite

BACterial Hosts for production of Bioactive phenolics from bERRY fruits (BacHBerry) was a 3-year project funded by the Seventh Framework Programme (FP7) of the European Union that ran between November 2013 and October 2016. The overall aim of the project was to establish a sustainable and economically-feasible strategy for the production This article is written by the BacHBerry consortium (www. bachberry.eu) and represents the collective effort of all participating institutions. The authors are therefore listed in alphabetical order.Electronic supplementary material The online version of this article

show abstract

Theoretical investigation on excited state intramolecular proton transfer of 5-hydroxy-6,7,4'-trimethoxyflavone: state specific solvation approach versus linear response solvation

Das,

Gangopadhyay

2024

Molecular Physics

View full text Add to dashboard Cite

Microbial production of flavonoids and terpenoids

Cited by 3 publications

References 96 publications

Engineering of Microbial Cell Factories for the Production of Plant Polyphenols with Health-Beneficial Properties

Engineering of Microbial Cell Factories for the Production of Plant Polyphenols with Health-Beneficial Properties

BacHBerry: BACterial Hosts for production of Bioactive phenolics from bERRY fruits

Theoretical investigation on excited state intramolecular proton transfer of 5-hydroxy-6,7,4'-trimethoxyflavone: state specific solvation approach versus linear response solvation

Contact Info

Product

Resources

About