Microbial Profiles of Patients With Antipsychotic-Related Constipation Treated With Electroacupuncture

Zheng, Yao; Jiang, Xiumin; Gao, Yacen; Yuan, Lexin; Wang, Xiaotong; Wu, Shengwei; Xia, Yucen; Yao, Lin; Yan, Jun; Liu, Lanying; Wei, Yiheng; Song, Zhiqiang; Lin, Yongcheng; Chen, Yongjun

doi:10.3389/fmed.2021.737713

Cited by 9 publications

(11 citation statements)

References 83 publications

(109 reference statements)

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“…The effect of GM on Parabacteroides was greater than that on GMOS. Parabacteroides have the ability to metabolize carbohydrates and produce SCFAs [35], and have beneficial effects on metabolic disorders [36,37]. However, it is debatable whether Parabacteroides are beneficial or pathogenic.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Enzymatic Production and Prebiotic Activity of Galactomannan Oligosaccharides Derived from Gleditsia microphylla

et al. 2023

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Oligosaccharides have received considerable attention as prebiotics because they exhibit potential health benefits related to their ability to modulate intestinal bacterial composition. This study evaluated the effects of galactomannan oligosaccharides (GMOS) derived from Gleditsia microphylla as a prebiotic on human intestinal bacteria. The β-mannanase used for the enzymatic hydrolysis of GMOS was produced by Trichoderma reesei Rut C-30. The enzymatic hydrolysis of GMOS was found to occur under optimal conditions at 50 °C, pH 5, 20 U/g-GM, and 20 g/L, and resulted in a yield of 70.78% ± 1.34%. The purity of GMOS after purification was 81.50%. Upon performing in vitro human fecal fermentation using GMOS as a carbon source, it was observed that GMOS effectively promoted the proliferation of intestinal bacteria, and the utilization efficiency of GMOS by intestinal bacteria was found to be at 98.40%. In addition, GMOS were found to have a stabilizing effect on intestinal pH. Additionally, 16S rRNA sequencing of GMOS revealed that GMOS significantly affected the diversity of gut microbiota. Specifically, GMOS exhibited a significant inhibitory effect on Fusobacteria at the phyla and genus level, and demonstrated a significant inhibitory effect on Fusobacterium. Moreover, the results for the prediction of metabolic function analysis showed that GMOS had a significant effect on the level two metabolism of carbohydrates, cofactors, and vitamins. Furthermore, during level three metabolism, the lipoic acid metabolism was significantly affected by GMOS. These results provide a theoretical basis for the potential use of galactomannan oligosaccharides from Gleditsia microphylla as prebiotics for regulating human intestinal bacteria.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the Enzymatic Production and Prebiotic Activity of Galactomannan Oligosaccharides Derived from Gleditsia microphylla

et al. 2023

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“…Acupuncture, as one of the TCM therapy methods, has been found to modulate the composition of intestinal flora in the progression of treating some diseases. [164][165][166]. Although there were few clinical trials exploring the mechanism of acupuncture in the management of diabetes from the perspective of intestinal flora, animal tests have manifested electroacupuncture was beneficial in increasing the diversity of gut flora and promoting colonic motility, which may be used to explain its hypoglycemic mechanism.…”

Section: Acupuncture Therapymentioning

confidence: 99%

Non-drug interventions of traditional Chinese medicine in preventing type 2 diabetes: a review

Liu,

Yao,

Wang

et al. 2023

Chin Med

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Traditional Chinese medicine (TCM) is increasingly used to manage type 2 diabetes and its nonpharmacological interventions are showing potential for preventing type 2 diabetes. This study mainly reviews relevant research. The most mentioned non-drug treatments for preventing type 2 diabetes in TCM are healthy diet, physical activity, emotional therapy, and acupuncture. In most studies, blood glucose status in patients with prediabetes and type 2 diabetes was significantly improved after TCM non-drug interventions, and there was no significant difference between the adverse effect of TCM and control groups or other intervention groups, while the methodological quality of the clinical trials involving TCM generally kept a low level. The effectiveness of TCM in preventing type 2 diabetes has yet to be validated in large randomized controlled trials and the underlying mechanism also needs further exploration.

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“…As described previously, some evidence in animal models of acupuncture on obesity and modulation of gut microbiota composition is presented. In humans, the evidence is still scarce but emerging changes in species abundance and diversity of the gut microbiome have been documented in patients undergoing treatment with EA ( 49 , 53 , 198 ). In perimenopausal women with abdominal obesity, EA for eight weeks in combination with diet decreased the abundance of the species and increased the species diversity of gut microbiota ( 49 ).…”

Section: Acupuncture Clinical Human Studiesmentioning

confidence: 99%

“…A recent sham-controlled study in adults with antipsychotic-related constipation treated with EA showed that richness of various bacterial strains such as Klebsiella and Gammaproteobacteria was significantly higher after acupuncture, and was associated with significantly increased spontaneous bowel movements and reduced use of rescue medication. Moreover, Firmicutes-to-Bacteroidetes ratio was increased post-treatment ( 198 ). In a population of patients with knee osteoarthritis, eight weeks of EA modified gut microbiota diversity and microbiota richness of species ( 53 ).…”

Section: Acupuncture Clinical Human Studiesmentioning

confidence: 99%

Acupuncture as multi-targeted therapy for the multifactorial disease obesity: a complex neuro-endocrine-immune interplay

Landgraaf,

Bloem,

Fumagalli

et al. 2023

Front. Endocrinol.

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The prevalence of obesity has reached pandemic dimensions. It is associated with multiple comorbidities and is becoming a clinical and public health threat. Obesity is a multifactorial disease with a complex pathophysiology and interplay of various systems. A strong interplay exists between the neuro-endocrine system, the immune system with systemic chronic low-grade inflammation, and microbiome dysbiosis that can lead to the development of obesity, which in turn can exacerbate each of these factors, hence creating a vicious cycle. The conventional treatment with lifestyle modifications such as diet, physical exercise, pharmacotherapy, and bariatric surgery does not always result in sufficient weight control thus paving the way for other strategies. As one such strategy, acupuncture is increasingly used worldwide to treat obesity. This narrative review outlines the evidence for this neuro-endocrine-immune interplay in the pathophysiology of obesity. Furthermore, the existing experimental and clinical evidence of acupuncture as a multi-targeted therapy for obesity is explained and future research perspectives are discussed.

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Microbial Profiles of Patients With Antipsychotic-Related Constipation Treated With Electroacupuncture

Cited by 9 publications

References 83 publications

Evaluation of the Enzymatic Production and Prebiotic Activity of Galactomannan Oligosaccharides Derived from Gleditsia microphylla

Evaluation of the Enzymatic Production and Prebiotic Activity of Galactomannan Oligosaccharides Derived from Gleditsia microphylla

Non-drug interventions of traditional Chinese medicine in preventing type 2 diabetes: a review

Acupuncture as multi-targeted therapy for the multifactorial disease obesity: a complex neuro-endocrine-immune interplay

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