Microbial resistance: The role of efflux pump superfamilies and their respective substrates

Garcia, Ítalo Rodrigues; Garcia, Francisca Adilfa de Oliveira; Pereira, Pedro Silvino; Coutinho, Henrique Douglas Melo; Siyadatpanah, Abolghasem; Norouzi, Roghayeh; Wilairatana, Polrat; Pereira, Maria de Lourdes; Nissapatorn, Veeranoot; Tintino, Saulo Relison; Rodrigues, Fabíola Fernandes Galvão

doi:10.1016/j.lfs.2022.120391

Cited by 24 publications

(11 citation statements)

References 283 publications

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“…[ 42 43 ] Gram-positive bacteria are more easily eliminated than gram-negative bacteria because they have a porous cell wall. [ 44 ] Bacteria that were gram-positive and nonpathogenic made composed the organisms in group 2. Therefore, a lower concentration of chlorhexidine (0.01%) was sufficient to eradicate all the germs.…”

Section: Discussionmentioning

confidence: 99%

Sterilizing orthodontic appliances: A systematic review and meta-analysis on the available methods

Abutayyem,

Alam,

Kanwal

et al. 2023

Journal of Orthodontic Science

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Infection control is essential to protect both the doctor and the patient by preventing the spread of infectious diseases. There is no exception in the field of dentistry, particularly in orthodontics, where numerous appliances are used for a variety of functions and also because the mouth cavity has the highest concentration of bacteria of any body part. Through this systematic review, we aimed to assess the various methods of sterilization employed in an orthodontic setting. Using relevant keywords, reference searches, and citation searches, the databases such as PubMed, MEDLINE, Web of Science, Cochrane, and Scopus were all searched; a total of 206 documents were found, of which 113 were initially selected. The remaining 23 distinct papers were initially made available after 90 publications that were identical to or similar to one another were eliminated. The final selection was made from eight documents that met all inclusion and exclusion requirements. The existing methods of sterilization were found to be competent in dealing with the microorganisms found in a typical orthodontic setting. The chemical method of sterilization was the norm in most of the studies that we assessed, with glutaraldehyde and peracetic acid (PAA) being the most commonly employed compounds for disinfection. PROSPERO Registration Number: CRD42022380831.

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Section: Discussionmentioning

confidence: 99%

Sterilizing orthodontic appliances: A systematic review and meta-analysis on the available methods

Abutayyem,

Alam,

Kanwal

et al. 2023

Journal of Orthodontic Science

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“…Certain bacteria possess these genes on their chromosomes, providing an inherent survival mechanism in challenging environments. 28 In contrast, other bacteria can procure these genes through diverse mechanisms such as mutations within local repressor genes, activation of a regulon controlled by a global transcriptional regulator, or the presence of efflux pump genes on plasmids. 28 For example, the RND family efflux pumps play a crucial role in the intrinsic antibiotic resistance of gram-negative bacteria by actively expelling a diverse array of antibiotics and antimicrobials.…”

Section: Active Effluxmentioning

confidence: 99%

“…28 In contrast, other bacteria can procure these genes through diverse mechanisms such as mutations within local repressor genes, activation of a regulon controlled by a global transcriptional regulator, or the presence of efflux pump genes on plasmids. 28 For example, the RND family efflux pumps play a crucial role in the intrinsic antibiotic resistance of gram-negative bacteria by actively expelling a diverse array of antibiotics and antimicrobials. 29 In gram-positive bacteria, the efflux pumps provide intrinsic resistance as they are encoded on the chromosome.…”

Section: Active Effluxmentioning

confidence: 99%

Antimicrobial Resistance: Techniques to Fight AMR in Bacteria – A Review

Mahizhchi,

Sivakumar,

Jayaraman

2024

J. Pure Appl. Microbiol.

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Antimicrobials or antibiotics were the important revelations of the last century, however, it came along with a silent curse that people care less to talk about. Antimicrobial resistance (AMR) which emerged alongside antibiotics in the last century has been a significant concern for scientists and policymakers. Since their discovery, it has been noted that the widespread use of antibiotics is the primary cause of bacteria developing antimicrobial drug resistance. Despite the recognition of this issue, it is challenging to curtail the widespread use of antibiotics because they are essential for treating various infections. Paradoxically, the necessity of using these drugs becomes an inadvertent advantage for bacteria to evolve resistance mechanisms. This dilemma creates a seeming stalemate in our battle against these tiny microorganisms. Delaying action could have dire consequences, potentially leading to the emergence of stronger superbugs that pose a serious threat to the entire human population. The recent COVID-19 pandemic serves as a stark reminder of the devastating impact a small microbe can have on global health. This paper delves into the mechanisms of antimicrobial resistance in bacteria, the evolution of superbugs and the innovative techniques employed by scientists to combat these challenges. Taking proactive steps is crucial to avoid a future where we are at the mercy of increasingly resilient microbes.

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“…Thus, bacterial resistance has a very strong negative influence on the health of the wider population and the economy. For example, in the United States, over 2 million human infections with MDR microorganisms are registered annually, of which 23,000 have fatal outcomes [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Antimicrobial Activity of Kitaibelia vitifolia Extract against Proven Antibiotic-Susceptible and Multidrug-Resistant (MDR) Strains of Bacteria of Clinical Origin

Kurćubić,

Raketić,

Mašković

et al. 2023

Plants

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The goal of the present research was to screen the antimicrobial activity of an ethanolic extract of Kitaibelia vitifolia against 30 multidrug-resistant (MDR) bacterial strains isolated from healthcare-associated infections. Minimum inhibitory concentrations (MICs) of the samples against the tested bacteria were determined using the microdilution method. MDR bacterial strains were characterized using standard biochemical tests and the commercial identification systems API 20 NE and API 20 E as: Klebsiella spp. (18 isolates—I); methicillin-resistant Staphylococcus aureus (MRSA)—3; Acinetobacter spp.—3; Pseudomonas aeruginosa—5; vancomycin-resistant Enterococcus (VRE)—1. The sensitivity of isolated bacterial strains was determined using the disc diffusion method against 25 commonly used antibiotics. The highest level of sensitivity to K. vitifolia extract was confirmed in 88.89% of Klebsiella spp. isolates, E. coli ATCC 25922, two strains of MRSA (1726, 1063), Acinetobacter spp. strain 1578, and VRE strain 30, like Enterococcus faecalis ATCC 29212 (MIC =< 2.44 μg/mL). The lowest sensitivity was exhibited by 75.00% of Acinetobacter spp. (strains 1577 and 6401), where the highest values for MICs were noted (1250 μg/mL). The results indicate that the extract of K. vitifolia could be a possible source for creating new, efficient, and effective natural medicines for combat against MDR strains of bacteria.

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Microbial resistance: The role of efflux pump superfamilies and their respective substrates

Cited by 24 publications

References 283 publications

Sterilizing orthodontic appliances: A systematic review and meta-analysis on the available methods

Sterilizing orthodontic appliances: A systematic review and meta-analysis on the available methods

Antimicrobial Resistance: Techniques to Fight AMR in Bacteria – A Review

Evaluation of Antimicrobial Activity of Kitaibelia vitifolia Extract against Proven Antibiotic-Susceptible and Multidrug-Resistant (MDR) Strains of Bacteria of Clinical Origin

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