Microbicidal activity of neutrophils is inhibited by isolates from recurrent vaginal candidiasis (RVVC) caused by Candida albicans through fungal thioredoxin reductase

Ratti, Bianca Altrão; Godoy, Janine Silva Ribeiro; Mendonca, Patricia; Bidóia, Danielle Lazarin; Ueda-Nakamura, Tânia; Nakamura, Celso Vataru; Consolaro, Márcia Edilaine Lopes; Svidzinski, Terezinha Inez Estivalet; Silva, Sueli de Oliveira

doi:10.1016/j.cellimm.2014.11.004

Cited by 21 publications

(9 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many practitioners [18,19,33,34] believe that VVC is always accompanied with strong polymorphonuclear inflammatory reaction, but this concept was not confirmed by the results in our study. De Souza Bonfim-Mendonça et al [35] comment that, in VVC episodes, neutrophils are known to be markedly recruited to the site of infection and play a key role in the host defence by killing microbes [36].…”

Section: Aetiology Of Vvc and Association With Microscopic Signs Of Icontrasting

confidence: 90%

Analysis of clinical and microbiological indicators of vulvovaginal candidiasis

Dermendzhiev

Hadzhieva²,

Дерменджиев

et al. 2016

Biotechnology & Biotechnological Equipment

View full text Add to dashboard Cite

Vulvovaginal candidiasis (VVC) is the most common vaginal infection. It is considered to be the reason for 15%-30% of all vulvovaginal symptoms. A diagnosis based only on clinical signs and/or on a syndrome-based approach, recommended by some authors and health institutions, is in many cases incorrect. There is no indisputable diagnostic method that guarantees high specificity, sensitivity and predictive value. There is no pathognomonic clinical feature of VVC. The aim of the present study was to assess the role of selected clinical and mycological indicators in the diagnosis of VVC using the standard complex scoring system. The research is retrospective and was conducted in several stages to give a more precise and detailed assessment of the examined clinical and microbiological indicators. Clinical, microbiological and statistical methods were used. The results showed the lowest level of compliance between clinical and laboratory diagnosis in VVC: 67.65%. We did not observe a statistically significant relation between the density of the vaginal smear, inflammation, odour test and VVC (p > 0.05). The results showed a moderate association between the positive yellow swab test and VVC (p < 0.05). A significant positive association was established between VVC and presence of microscopic signs of invasiveness (p < 0.001). The most common isolate was Candida albicans: 72.81% of all vaginal Candida isolates.

show abstract

Section: Aetiology Of Vvc and Association With Microscopic Signs Of Icontrasting

confidence: 90%

Analysis of clinical and microbiological indicators of vulvovaginal candidiasis

Dermendzhiev

Hadzhieva²,

Дерменджиев

et al. 2016

Biotechnology & Biotechnological Equipment

View full text Add to dashboard Cite

show abstract

“…In a study conducted on cells isolated from the vaginal discharge of patients with recurrent vulvovaginal candidiasis (RVVC), it was demonstrated that the candida albicans strains isolated from these patients had higher levels of reduced thiol. It was considered that they were protected from oxidative stress and became resistant to treatment and thus experienced recurrent infections through this mechanism [17]. In another study in which oxidative stress was evaluated in the amniotic fluid of pregnant women with bacterial vaginosis, it was stated that MDA, SOD and GSh-PX levels did not show any significant difference between the control and patient groups [18].…”

Section: Discussionmentioning

confidence: 99%

Dynamic Thiol/Disulphide Homeostasis in Patients with Vaginitis

Desdicioğlu¹

2018

JGO

View full text Add to dashboard Cite

This study investigated the thiol-disulphide balance in vaginitis, which is a local inflammatory condition, through the use of a new method. A cross-sectional study involving 82 women (45 women with vaginitis and 37 women in control group) was conducted at Ataturk Education and Research Hospital, Ankara, Turkey from February 2016 to April 2016. Their ages varied between 19-75 years (mean: 42.8±11.6), were incorporated into the study. Thiol-disulphide parameters were measured and the obtained results were compared. The results showed that the serum disulphide level and disulphide/native thiol ratio in the group with vaginitis (p = 0.03 and p = 0.04) and the native thiol/total thiol ratio in the control group was higher (p = 0.03). In this study, it was shown that serum dynamic thiol-disulphide balance in the women with vaginitis had varied. Although vaginitis is a localized infectious inflammatory condition, the increase in the systemic oxidative stress is important. This study is the first article in the literature that investigates the relationship between dynamic thiol-disulphide balance and vaginitis.

show abstract

“…can cope with oxidative and nitrosative stress, because the enzymes present such as catalases, peroxidases, thioredoxin and superoxide dismutases can detoxify the immune response of the macrophages [ 112 ]. However, our studies [ 10 , 84 ] found that LAM can stimulate professional phagocytes to produce larger amounts of chemical mediators and overcome the detoxification capacity of some fungal strains. In addition, the activation of Dectin-1 by LAM may stimulate other biochemical processes such as the increased recruitment of leukocytes and phagosome maturation leading to more rapid phagocytosis [ 113 ].…”

Section: New Perspectives Of the Application Of Lammentioning

confidence: 97%

“…In this context, our research group sought to know more about the innate immune response in VVC of women with different symptoms. Clinical isolates of Candida albicans [ 84 ] and C. glabrata [ 5 ] from women with recurrent VVC (RVVC) exhibited different behavior in the presence of human neutrophils. C. albicans were resistant to the action of neutrophils, mainly by releasing detoxification enzymes, while C. glabrata were susceptible to the killing action.…”

Section: Immunomodulatory Properties Of Lammentioning

confidence: 99%

Overview of β-Glucans from Laminaria spp.: Immunomodulation Properties and Applications on Biologic Models

Mendonca

Capoci

Tobaldini-Valério

et al. 2017

IJMS

View full text Add to dashboard Cite

Glucans are a group of glucose polymers that are found in bacteria, algae, fungi, and plants. While their properties are well known, their biochemical and solubility characteristics vary considerably, and glucans obtained from different sources can have different applications. Research has described the bioactivity of β-glucans extracted from the algae of the Laminaria genus, including in vivo and in vitro studies assessing pro- and anti-inflammatory cytokines, vaccine production, inhibition of cell proliferation, and anti- and pro-oxidant activity. Thus, the objective of this article was to review the potential application of β-glucans from Laminaria spp. in terms of their immunomodulatory properties, microorganism host interaction, anti-cancer activity and vaccine development.

show abstract

Microbicidal activity of neutrophils is inhibited by isolates from recurrent vaginal candidiasis (RVVC) caused by Candida albicans through fungal thioredoxin reductase

Cited by 21 publications

References 31 publications

Analysis of clinical and microbiological indicators of vulvovaginal candidiasis

Analysis of clinical and microbiological indicators of vulvovaginal candidiasis

Dynamic Thiol/Disulphide Homeostasis in Patients with Vaginitis

Overview of β-Glucans from Laminaria spp.: Immunomodulation Properties and Applications on Biologic Models

Contact Info

Product

Resources

About