Microbiologic and Clinical Features of Salmonella Species Isolated From Bacteremic Children in Eastern Democratic Republic of Congo

Vandenberg, Olivier; Nyarukweba, D Zozo; Ndeba, Prudence M.; Hendriksen, René S.; Barzilay, Ezra J.; Schirvel, Carole; Bisimwa, Balaluka B.; Collard, Jean-Marc; Kane, Awa; Aarestrup, Frank Møller

doi:10.1097/inf.0b013e3181cd615a

Cited by 41 publications

(48 citation statements)

References 41 publications

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“…267,271 Multidrug resistance and decreased susceptibility to fl uoroquinolones are now widespread among non-typhoidal salmonella, causing invasive bacterial disease in Kenya and Malawi, [272][273][274] and other parts of sub-Saharan Africa. [275][276][277] This situation poses a major challenge to treatment and management of disease. In a study from the Democratic Republic of the Congo, 278 rates of multidrug resistance varied from 37% to 80% between diff erent provinces.…”

Section: The Lancet Infectious Diseases Commissionmentioning

confidence: 99%

Antibiotic resistance—the need for global solutions

Laxminarayan

Dusé

Wattal

et al. 2013

The Lancet Infectious Diseases

3,580

2,602

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The causes of antibiotic resistance are complex and include human behaviour at many levels of society; the consequences aff ect everybody in the world. Similarities with climate change are evident. Many eff orts have been made to describe the many diff erent facets of antibiotic resistance and the interventions needed to meet the challenge. However, coordinated action is largely absent, especially at the political level, both nationally and internationally. Antibiotics paved the way for unprecedented medical and societal developments, and are today indispensible in all health systems. Achievements in modern medicine, such as major surgery, organ transplantation, treatment of preterm babies, and cancer chemotherapy, which we today take for granted, would not be possible without access to eff ective treatment for bacterial infections. Within just a few years, we might be faced with dire setbacks, medically, socially, and economically, unless real and unprecedented global coordinated actions are immediately taken. Here, we describe the global situation of antibiotic resistance, its major causes and consequences, and identify key areas in which action is urgently needed.

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Section: The Lancet Infectious Diseases Commissionmentioning

confidence: 99%

Antibiotic resistance—the need for global solutions

Laxminarayan

Dusé

Wattal

et al. 2013

The Lancet Infectious Diseases

3,580

2,602

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“…Salmonella typhimurium and Salmonella enteritidis were responsible for 82% of the cases. 5 In Mozambique, NTS were reported to account for 120 cases of childhood bacteraemia per 100 000 persons/year. 6 Contaminated poultry meat and eggs, among other factors, have been implicated as vehicles of transmission for these hardy pathogens.…”

Section: Introductionmentioning

confidence: 99%

Incidence of non-typhoidal Salmonella in poultry products in the North West Province, South Africa

Olobatoke¹,

Mulugeta²

2015

S. Afr. J. Sci.

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This study was conducted to evaluate the incidence of non-typhoidal Salmonella (NTS) serotypes in raw and ready-to-eat (RTE) broiler products in the North West Province of South Africa. A total of 120 raw broiler samples, 40 samples of polonies and 20 samples of smoked viennas were obtained from retail points in major cities and towns in the province. Samples were subjected to aerobic plate count and later screened for the presence of NTS using phenotypic and genotypic techniques. The average bacterial count in raw products was 3.1 x 10 5 cfu/g whereas bacterial contamination of RTE products was 1.8 x 10 3 cfu/g. The average recovery rate of NTS species from raw broiler products was 12.5% and the serotypes identified were S. typhimurium (46.4%), S. enteritidis (30.9%) and S. newport (22.9%). No NTS was recovered from the RTE products. However, S. typhimurium was the predominant serotype in whole carcasses whereas S. enteritidis and S. newport were prevalent in chicken parts. Out of the 160 presumptive NTS isolates screened by polymerase chain reaction (PCR), 140 (87.5%) were confirmed for the presence of the Salmonella-specific invA gene. In addition, 115 (82.4%) of the confirmed isolates harboured the plasmid spvC gene. Random Amplified Polymorphic DNA (RAPD) fingerprinting of isolates using RAPD 1 and RAPD 3 primers, revealed some inter-and intra-serotype genetic diversity among isolates, suggesting varying sources of contamination. The results of this study represent the first report on the incidence and prevalent serotypes of NTS in chicken products in the North West Province of South Africa.

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“…In contrast to the situation in many countries (Glynn et al, 1998;Vandenberg et al, 2010), Salmonella Typhimurium in Mauritius remain remarkably susceptible to most antibiotics, with resistance rates in Salmonella serogroup O:4 isolated from 1998 to 2009 of around 5% to ampicillin and co-trimoxazole, and < 1% to quinolones (unpublished data). It is difficult to obtain information from poultry producers on their use of antimicrobials, but the resistance data available suggest that antibiotics are not used widely.…”

Section: Discussionmentioning

confidence: 98%

Dissemination of ClonalSalmonella entericaSerovar Typhimurium Isolates Causing Salmonellosis in Mauritius

Issack

Migura-García

Ramsamy

et al. 2013

Foodborne Pathogens and Disease

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Microbiologic and Clinical Features of Salmonella Species Isolated From Bacteremic Children in Eastern Democratic Republic of Congo

Abstract: Our findings indicate the benefit to strengthen laboratory capacities in Africa, allowing the development of management guidelines of bloodstream infection.

Cited by 41 publications

References 41 publications

Antibiotic resistance—the need for global solutions

Antibiotic resistance—the need for global solutions

Incidence of non-typhoidal Salmonella in poultry products in the North West Province, South Africa

Dissemination of ClonalSalmonella entericaSerovar Typhimurium Isolates Causing Salmonellosis in Mauritius

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