Microbiologic profile and clinical practices in urinary tract infections in a tertiary care center in Southern India

Kiranmala, Keithellakpam; Johnson, Reuben C; Savio, Jayanthi; Idiculla, Jyothi

doi:10.4103/jfmpc.jfmpc_346_19

Cited by 6 publications

(9 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A study that is very much in line with our findings was conducted in Sudan, which also found E. coli (56.4%), Klebsiella pneumonia (23.0%), and Enterococcus faecalis (12.8%) to be the most common organisms [17]. A study conducted in Southern India among diabetic patients had similar organisms cultured from their patients, but with dissimilar frequencies [22,29]. Klebsiella pneumonia (42.4%), E. coli (21.2%), and Enterococcus faecalis (12.1%) were isolated in the study in Nigeria [22], while E. coli (67%), Enterococcus (9%), and Klebsiella (14%) were found in the study conducted in Southern India [29].…”

Section: Discussionsupporting

confidence: 83%

“…A study conducted in Southern India among diabetic patients had similar organisms cultured from their patients, but with dissimilar frequencies [ 22 , 29 ]. Klebsiella pneumonia (42.4%), E. coli (21.2%), and Enterococcus faecalis (12.1%) were isolated in the study in Nigeria [ 22 ], while E. coli (67%), Enterococcus (9%), and Klebsiella (14%) were found in the study conducted in Southern India [ 29 ]. Zhanel et al found a prevalence of E. coli (52.9%) that is similar to ours, but also isolated Streptococcus species (11.4%) and Staphylococcus species (5.9%) in their study [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Characteristics of Asymptomatic Bacteriuria in Diabetes Mellitus Patients: A Retrospective Observational Study

Asghar¹,

Akram²,

Singh³

et al. 2021

Cureus

View full text Add to dashboard Cite

Background and objective The term asymptomatic bacteriuria (ASB) refers to the isolation of bacteria in a urine specimen of individuals without any symptoms of urinary tract infection (UTI). Diabetes mellitus (DM) is a disease involving multiple organ systems, characterized by its chronicity and hence endless complications including ASB. This study aimed to determine the characteristics of ASB and antibiotic susceptibility patterns among patients with diabetes. Materials and methods This was a retrospective observational study conducted in a tertiary care hospital. The study included patients with a diagnosis of diabetes with no signs and symptoms of UTI but who still showed the growth of an organism in urine culture. A total of 222 urine cultures were analyzed retrospectively, ensuring that they met the inclusion criteria through non-probability consecutive sampling. Results The mean age of the study participants was 62.89 ± 13.77 years; 76% of them were females, and 61% had a family history of diabetes. The most frequent organisms isolated were Escherichia coli (E. coli), Enterococcus, Klebsiella pneumonia, Pseudomonas aeruginosa, and Enterobacter species. A total of 20 subjects had dual bacterial growth in their cultures, with Enterococcus species (n=17) being the most common organism. Gender, family history of diabetes, levels of hemoglobin A1c (HbA1c), and advanced age were all found significantly associated with ASB. Conclusion Our study is the first of its kind to analyze and examine the risk factors associated with ASB in DM patients, and to identify the pathogens involved, along with assessing their antibiotic resistance profiles.

show abstract

Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Characteristics of Asymptomatic Bacteriuria in Diabetes Mellitus Patients: A Retrospective Observational Study

Asghar¹,

Akram²,

Singh³

et al. 2021

Cureus

View full text Add to dashboard Cite

show abstract

“…Nigussie et al ., found that E. coli was sensitive to nitrofurantoin (100%), norfloxacin (90.9%), ciprofloxacin (81.8%), but resistant to Ampicillin (100%), trimethoprim-sulfamethoxazole (81.8%), gentamicin (72.7%). [ 43 ] This study also showed that E. coli was resistant to Gentamicin (72.7%),[ 42 ] but our study showed it was susceptible to Gentamicin (66.7%). The resistance of E. coli in this study to Ampicillin was 100%,[ 43 ] compared to our results which shows a resistance of 86.04%.…”

Section: Discussionmentioning

confidence: 53%

“…[ 31 ] Klebsiella pneumonia (42.4%), E. coli (21.2%), and E. faecalis (12.1%) were isolated from the study in Nigeria,[ 19 ] while E. coli (67%), Enterococcus (9%), Klebsiella (14%) were found in the study conducted in Southern India. [ 42 ] Odetoyin et al ., performed a study where the isolated organisms were Staphylococcal aureus (80.9%), Klebsiella (9.5%), Enterococcus faecalis (4.8%), and E. coli (4.8%). [ 30 ]…”

Section: Discussionmentioning

confidence: 99%

Asymptomatic Bacteriuria (ASB) in diabetic patients

Tauseef

Zafar

Syyed

et al. 2021

Journal of Family Medicine and Primary Care

View full text Add to dashboard Cite

Background: The term asymptomatic bacteriuria (ASB) refers to the isolation of bacteria in a urine specimen of individuals who denied symptoms of urinary tract infection. Diabetes mellitus (DM) is a disease involving multiple organ systems, hallmarked for its chronicity and thus-forth endless complications including asymptomatic bacteriuria. Objectives: This study aimed to determine the characteristics of asymptomatic bacteriuria and antibiotic susceptibility pattern amongst patients with diabetes. Settings and Design: A prospective observational study was conducted at a tertiary care hospital in Karachi, Pakistan. Methods and Material: The study included all those patients with a diagnosis of diabetes with no signs and symptoms of urinary tract infection but showing the growth of an organism in urine culture. Pregnant females and subjects who used antibiotics in last two weeks were excluded. A total of 222 urine cultures were observed prospectively who met the inclusion criteria through non-probability consecutive sampling. Results: Out of 222 urine cultures observed, mean age of subjects were 62.89 ± 13.77 out of which 76% were females, and 61% had a family history of diabetes. The most frequent organisms isolated were Escherichia. Coli ( E. Coli ), Enterococcus, Klebsiella, Pseudomonas, and Enterobacter species. A total of 20 subjects got dual bacterial growth in their cultures among which 17 subjects had a growth of Enterococcus with any other pathogen causing UTI. Gender, family history of diabetes, levels of HBA1c, and older age groups all were found significantly associated with ASB. Conclusions: Our study is the first to analyze and study the associated risk factors amongst ASB in DM patients, and to identify the pathogens involved along with assessing their antibiotic resistance profiles. Also, due to the increase resistance to antibiotics we would recommend to use antibiotics in ASB patients only if they have any two or more comorbidities.

show abstract

“…Antibiotic resistance is significant, with varying resistance rates to common antibiotics, presenting a pressing challenge [ 15 ]. In South India and Sri Lanka, high resistance rates to antibiotics like quinolones and penicillins have been reported, though some, like imipenem, retain effectiveness [ 3 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

The Clinical Profile of Patients With Culture-Positive Urinary Tract Infections Admitting to a Tertiary Hospital in Sri Lanka

Samarawickrama,

Illangakoon,

Uthuman

et al. 2024

Cureus

View full text Add to dashboard Cite

Introduction Urinary tract infections (UTIs) are globally prevalent. This study explores the clinical and pathological profile of culture-positive UTI patients at Sri Jayewardenepura General Hospital. Method In this descriptive cross-sectional study conducted at Sri Jayewardenepura General Hospital from December 2020 to May 2021, we evaluated patients over 14 years with positive urine culture reports. Excluding those with HIV, undergoing chemotherapy, or pregnant, we used consecutive sampling. Data were collected via interviewer-administered questionnaires and analyzed using SPSS version 21.0 (IBM Inc., Armonk, New York), employing descriptive statistics and Fisher's exact tests to identify factors associated with urinary tract infections. Results The study involved approximately 278 participants. The mean age remained 60 ± 20.279 years, with over half of the participants being female. Common symptoms like fever and lower abdominal pain were observed in 22.30% of cases. The incidence of acute kidney injury was 30.58%. Escherichia coli (36%) and Klebsiella pneumoniae (26%) were the predominant organisms found. Indwelling catheters and other urinary tract conditions were considered risk factors. Patients with at least one risk factor were more likely to receive antibiotics before the urine culture. Similarly, males exhibited a higher prevalence of at least a risk factor than females. Conclusion UTIs are a significant clinical issue in older populations, with females being more susceptible. Fever and abdominal pain were common symptoms. Escherichia coli and Klebsiella pneumoniae were the most frequent causative agents. Further research is necessary to identify risk factors and predictors of antimicrobial resistance in UTI patients.

show abstract

Microbiologic profile and clinical practices in urinary tract infections in a tertiary care center in Southern India

Cited by 6 publications

References 24 publications

Characteristics of Asymptomatic Bacteriuria in Diabetes Mellitus Patients: A Retrospective Observational Study

Characteristics of Asymptomatic Bacteriuria in Diabetes Mellitus Patients: A Retrospective Observational Study

Asymptomatic Bacteriuria (ASB) in diabetic patients

The Clinical Profile of Patients With Culture-Positive Urinary Tract Infections Admitting to a Tertiary Hospital in Sri Lanka

Contact Info

Product

Resources

About