Microbiological Effects of Consuming a Synbiotic Containing Bifidobacterium bifidum, Bifidobacterium lactis, and Oligofructose in Elderly Persons, Determined by Real-Time Polymerase Chain Reaction and Counting of Viable Bacteria

Bartosch, Sabine; Woodmansey, Emma J.; Paterson, James H.; McMurdo, Marion E. T.; Macfarlane, G.T.

doi:10.1086/426027

Cited by 174 publications

(112 citation statements)

References 33 publications

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“…Since members of B. lactis were also detected during the placebo period (in 46% of Physiological effects of probiotic yoghurt A Klein et al all subjects), this taxon may represent a component of the resident microbiota in these subjects. In recent human studies, B. lactis was detected in biopsy and faecal samples (Bartosch et al, 2005;Mättö et al, 2006). The increased numbers of B. lactis after 5 weeks of probiotic consumption may be a consequence of the good adhesion properties of this probiotic bacteria that have been shown in vitro by Ouwehand et al (1999).…”

Section: Discussionmentioning

confidence: 92%

Lactobacillus acidophilus 74-2 and Bifidobacterium animalis subsp lactis DGCC 420 modulate unspecific cellular immune response in healthy adults

Friedrich²,

et al. 2007

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Objective: It was determined whether a combination of Lactobacillus acidophilus (L. acidophilus) 74-2 and Bifidobacterium animalis subsp lactis DGCC 420 (B. lactis 420) affect the faecal microbiota as well as immunological parameters and blood lipids in healthy adults. Design: A placebo-controlled, double-blinded, randomized crossover trial was conducted. Subjects: Twenty-six healthy volunteers (mean age 25 years) were recruited by advertising in academical buildings. All of them completed the study. Methods: After 3-week run-in period, half of the volunteers consumed 300 g/day of yoghurt supplement containing probiotic strains L. acidophilus 74-2 and B. lactis 420, and the other half received the placebo product for a period of 5 weeks. The two groups were crossed during the following 5-week period. Blood and faecal samples were collected at the end of each period. The faecal content of probiotic bacteria, faecal short-chain fatty acids (SCFA), serum lipids and plasma immune system biomarkers were evaluated. Results: Faecal proportions of L. acidophilus and of B. lactis increased significantly from 0.02 to 0.19 and 0.4 to 1.4% (Po0.05), respectively. Percentages of granulocytes and monocytes showing phagocytic activity were significantly elevated from 92 to 95% during probiotic intervention, whereas their oxidative burst activity and specific immune parameters remained unaffected. Fecal SCFA and serum cholesterol levels were not influenced by the probiotics. However, serum concentrations of triacylglyceroles decreased significantly by 11.6% (Po0.05) in the probiotic supplementation period. Conclusions: L. acidophilus and B. lactis were recovered in faeces in significantly elevated numbers after supplementation. They are able to modulate unspecific cellular immune response indicated by the increased phagocytic activity.

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Section: Discussionmentioning

confidence: 92%

Lactobacillus acidophilus 74-2 and Bifidobacterium animalis subsp lactis DGCC 420 modulate unspecific cellular immune response in healthy adults

Friedrich²,

et al. 2007

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“…was found to increase the total number of bifidobacteria in faecal samples (Bartosch et al, 2005). In another study, it was shown that 8 g/day of short-chain FOS from sucrose also caused an increase in Bifidobacterium spp.…”

Section: Elderly Peoplementioning

confidence: 90%

The bifidogenic effect of inulin and oligofructose and its consequences for gut health

Meyer¹,

2009

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The bifidogenic effect of inulin and oligofructose is now well established in various studies, not only in adult participants but also in other age groups. This bifidogenic shift in the composition of the colonic microbiota is likely the basis for the impact of these prebiotic compounds on various parameters of colonic function. Mainly from animal and in vitro studies and also from some human trials, there are indications, for instance, that inulin-type fructans may reduce the production of potentially toxic metabolites and may induce important immune-mediated effects. This review discusses how these changes in the composition and activity of the colonic microbiota may affect gut health in healthy people, including in those who may experience some form of gastrointestinal discomfort.

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“…To establish that a probiotic has an effect on intestinal health, isolation of the probiotic from the stool is considered an important trait. Several studies document the ability of BB-12 ability to survive intestinal transit, which was considered an important criterion for use (Fukushima et al, 1997;Malinen et al, 2002;Ouwehand et al, 2004;Bartosch et al, 2005). Furthermore, BB-12 has been shown to impact immune function as well as impact absences from daycare for infants (Fukushima et al, 1998;Weizman et al, 2005;Kekkonen et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Study to investigate the potential of probiotics in children attending school

et al. 2011

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Background/Objectives: To determine if consumption of yogurt containing a high dose of probiotic (1 Â 10 10 colony-forming unit per 100 ml), Bifidobacterium animalis subsp. lactis (B. lactis), decreases absences in children 2-4 years attending daycare/ school centers. Subjects/Methods: We conducted a double-blinded, randomized, placebo-controlled, allocation concealment clinical trial in the Washington, DC area. Our active intervention was a strawberry yogurt-based drink supplemented with B. lactis BB-12. The placebo was indistinguishable from the active drink, differing only in absence of the probiotic BB-12.Results: A total of 172 children between the ages of 2 and 4 from the Washington, DC area were enrolled. The primary outcome, missed days of school because of illness per 100 days, was similar in both the active (2.54 days absent/100 school days) and control groups (2.42 days absent/100 school days) (P ¼ 0.873). Conclusions: The probiotic-containing yogurt-based beverage studied did not decrease absences because of illnesses in daycare/school for healthy children ages 2-4 years.

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Microbiological Effects of Consuming a Synbiotic Containing Bifidobacterium bifidum, Bifidobacterium lactis, and Oligofructose in Elderly Persons, Determined by Real-Time Polymerase Chain Reaction and Counting of Viable Bacteria

Abstract: Synbiotic consumption increased the size and diversity of protective fecal bifidobacterial populations, which are often very much reduced in older people.

Cited by 174 publications

References 33 publications

Lactobacillus acidophilus 74-2 and Bifidobacterium animalis subsp lactis DGCC 420 modulate unspecific cellular immune response in healthy adults

Lactobacillus acidophilus 74-2 and Bifidobacterium animalis subsp lactis DGCC 420 modulate unspecific cellular immune response in healthy adults

The bifidogenic effect of inulin and oligofructose and its consequences for gut health

Study to investigate the potential of probiotics in children attending school

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