Microbiome and Cancers, With Focus on Genitourinary Tumors

Cimadamore, Alessia; Santoni, Matteo; Massari, Francesco; Gasparrini, Silvia; Cheng, Liang; López-Beltrán, Antonio; Montironi, Rodolfo; Scarpelli, Marina

doi:10.3389/fonc.2019.00178

Cited by 27 publications

(19 citation statements)

References 40 publications

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“…drogen receptor axis-targeted therapies (ATT), the most common line of prostate cancer treatment [13]. Cimadamore et al [13] showed that Ruminococcaceae spp.…”

Section: Human Gastrointestinal Microbiotamentioning

confidence: 99%

“…drogen receptor axis-targeted therapies (ATT), the most common line of prostate cancer treatment [13]. Cimadamore et al [13] showed that Ruminococcaceae spp. and Akkermansia muciniphila, which are both involved in steroid hormone biosynthesis, were linked to a more favorable response to anti-programmed death-1 (PD-1) immunotherapy.…”

Section: Human Gastrointestinal Microbiotamentioning

confidence: 99%

“…Sfanos found similar results, with a distinct difference in the GI microbiota of those on ATT compared to those without prostate cancer. In prostate cancer patients taking ATT, there was a higher relative abundance of A. muciniphila and Ruminococcaceae spp., which Cimadamore et al [13] had described to be more favorable for anti-PD-1 immunotherapy [60]. Oral hormonal therapy for prostate cancer may influence GI micriobiota and have an effect on clinical responses and the antitumor effects of immunotherapy.…”

Section: Human Gastrointestinal Microbiotamentioning

confidence: 99%

“…When studying a similar hypothesis in humans, antibiotics were found to be associated with decreased progression-free survival in melanoma patients [12]. When environmental changes occur, the microbiome can be thrown into a state of dysbiosis which can lead to the promotion of inflammatory diseases and cancer through infiltration of the epithelial barrier [13].…”

Section: Introductionmentioning

confidence: 99%

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The human gastrointestinal microbiota and prostate cancer development and treatment

Sha

Stefil

et al. 2020

Investig Clin Urol

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The human gastrointestinal microbiome contains commensal bacteria and other microbiota that have been gaining increasing attention in the context of cancer development and response to treatment. Microbiota play a role in the maintenance of host barrier surfaces that contribute to both local inflammation and other systemic metabolic functions. In the context of prostate cancer, the gastrointestinal microbiome may play a role through metabolism of estrogen, an increase of which has been linked to the induction of prostatic neoplasia. Specific microbiota such as Bacteroides, Streptococcus, Bacteroides massiliensis, Faecalibacterium prausnitzii, Eubacterium rectalie, and Mycoplasma genitalium have been associated with differing risks of prostate cancer development or extensiveness of prostate cancer disease. In this Review, we discuss gastrointestinal microbiota's effects on prostate cancer development, the ability of the microbiome to regulate chemotherapy for prostate cancer treatment, and the importance of using Next Generation Sequencing to further discern the microbiome's systemic influence on prostate cancer.

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“…drogen receptor axis-targeted therapies (ATT), the most common line of prostate cancer treatment [13]. Cimadamore et al [13] showed that Ruminococcaceae spp.…”

Section: Human Gastrointestinal Microbiotamentioning

confidence: 99%

Section: Human Gastrointestinal Microbiotamentioning

confidence: 99%

Section: Human Gastrointestinal Microbiotamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The human gastrointestinal microbiota and prostate cancer development and treatment

Sha

Stefil

et al. 2020

Investig Clin Urol

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“…The role of the urogenital microbiota is under evaluation for its possible implications in urogenital diseases, both benign, such as urinary tract infections, urinary incontinence, interstitial cystitis, chronic prostatitis, urolithiasis [19,26,27], and malign, in regards to bladder, prostate, and kidney cancer [28,29].…”

Section: The Human Microbiotamentioning

confidence: 99%

The Human Microbiota and Prostate Cancer: Friend or Foe?

Massari

Mollica

Nunno

et al. 2019

Cancers

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The human microbiome is gaining increasing attention in the medical community, as knowledge on its role not only in health but also in disease development and response to therapies is expanding. Furthermore, the connection between the microbiota and cancer, especially the link between the gut microbiota and gastrointestinal tumors, is becoming clearer. The interaction between the microbiota and the response to chemotherapies and, more recently, to immunotherapy has been widely studied, and a connection between a peculiar type of microbiota and a better response to these therapies and a different incidence in toxicities has been hypothesized. As knowledge on the gut microbiota increases, interest in the residing microbial population in other systems of our body is also increasing. Consequently, the urinary microbiota is under evaluation for its possible implications in genitourinary diseases, including cancer. Prostate cancer is the most common cancer in the male population; thus, research regarding its etiology and possible factors correlated to disease progression or the response to specific therapies is thriving. This review has the purpose to recollect the current knowledge on the relationship between the human microbiota and prostate cancer.

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