Microbiome and the immune system: From a healthy steady-state to allergy associated disruption

Mezouar, Soraya; Chantran, Yannick; Michel, J.; Fabre, Alexandre; Dubus, Jean‐Christophe; Leone, Marc; Sérémé, Youssouf; Mège, Jean‐Louis; Ranque, Stéphane; Desnues, Benoît; Chanez, Pascal

doi:10.1016/j.humic.2018.10.001

Cited by 59 publications

(42 citation statements)

References 135 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There are evidences that gut microbiota plays a fundamental role in the healthy immune status maintenance. In particular, intestinal microflora and immune system are constantly shaping each other in a mutual aim to flourish and to keep the healthy individual in balance . The healthy state of the immune system in adulthood is related to the presence of a diversified microflora, which develops in early childhood thanks to a correct colonization sequence by different microorganisms.…”

Section: Classification Of Bacteria and Interaction With Disease Andmentioning

confidence: 99%

Emerging Insights on the Interaction Between Anticancer and Immunosuppressant Drugs and Intestinal Microbiota in Pediatric Patients

Lucafò

Franzin

Lagatolla

et al. 2019

Clinical Translational Sci

View full text Add to dashboard Cite

Diseases affecting the immune system, such as inflammatory bowel disease (IBD), juvenile idiopathic arthritis (JIA), and acute lymphoblastic leukemia (ALL), are pathological conditions affecting the pediatric population and are often associated with alterations in the intestinal microbiota, such as a decrease in bacterial diversity. Growing evidence suggests that gut microbiota can interfere with chemotherapeutic and immunosuppressant drugs, used in the treatment of these diseases, reducing or facilitating drug efficacy. In particular, the effect of intestinal microflora through translocation, immunomodulation, metabolism, enzymatic degradation, and reduction of bacterial diversity seems to be one of the reasons of interindividual variability in the therapeutic response. Although the extent of the role of intestinal microflora in chemotherapy and immunosuppression remains still unresolved, current evidence on bacterial compositional shifts will be taken in consideration together with clinical response to drugs for a better and personalized therapy. This review is focused on the effect of the intestinal microbiota on the efficacy of pharmacological therapy of agents used to treat IBD, JIA, and ALL.

show abstract

Section: Classification Of Bacteria and Interaction With Disease Andmentioning

confidence: 99%

Emerging Insights on the Interaction Between Anticancer and Immunosuppressant Drugs and Intestinal Microbiota in Pediatric Patients

Lucafò

Franzin

Lagatolla

et al. 2019

Clinical Translational Sci

View full text Add to dashboard Cite

show abstract

“…When there is a gut microbiome perturbation, dominant non-pathogenic microbiota decreases in number and reduces the resistant of colonization capacity, which in turn allows opportunistic pathogens to colonize the niches and leads to infection [29]. Due to intrinsic complexity and multiplicity of the human microbiota, experiments are needed to investigate the cause and correlation linkage between microbiota imbalance and human disease [40,41]. However, the research on human gut microbiota is still in its preliminary stage.…”

Section: Introductionmentioning

confidence: 99%

Linking gut microbiota with human diseases

et al. 2020

View full text Add to dashboard Cite

The authors state that they adhere with COPE guidelines on publishing ethics as described elsewhere at https://publicationethics.org/. The authors also undertake that they are not associated with any other third party (governmental or non-governmental agencies) linking with any form of unethical issues connecting to this publication. The authors also declare that they are not withholding any information that is misleading to the publisher in regard to this article.

show abstract

“…16 The microbiome plays a role in the function and polarization of macrophages towards proin ammatory (M1) as well as anti-in ammatory (M2). 17 Macrophage is one of the keys in the pathogenesis of leprosy. M1 type of macrophages were dominated in PB leprosy, while an M2 type of macrophages were dominated in MB type leprosy.…”

Section: Introductionmentioning

confidence: 99%

The First Report of Diversity Analyses of Skin Microbiome In Indonesian Leprosy Patient

Gunawan¹,

Achdiat²,

Suwarsa³

et al. 2020

Preprint

View full text Add to dashboard Cite

BackgroundSkin microbiome is quiet diverse. There are several factors influencing the skin microbiome, such as skin diseases. However, the effects of leprosy on the skin microbiome remain unclear and there are only a few studies about skin microbiome on leprosy. The aim of this study was to investigate the alpha diversity of skin microbiome on lesional site of multibacillary (MB) leprosy patients who visited the top referral hospital in West Java Indonesia. Here in this study we characterize the skin microbiome in leprosy patient in compared to healthy individual by using next generation 16S rRNA sequencing. A total 18 skin swab samples were collected from 18 samples (14 leprosy patients, 4 healthy individuals).ResultsTaxonomic analysis of leprous skin lesions revealed main five phyla: Proteobacteria, Actinobacteria, Firmicutes, Bacteroidetes, and Cyanobacteria. Proteobacteria and Firmicutes were overrepresented in leprosy patients, while Actinobacteria, Bacteroidetes, and Cyanobacteria were diminished in leprosy patients compared to healthy individuals. The main five genera in leprous skin lesions were Staphylococcus, Acinetobacter, Corynebacterium, Micrococcus, and Propionibacterium. Staphylococcus, Acinetobacter, and Micrococcus were enriched in leprosy patients, while Corynebacterium and Propionibacterium which have a protective role in normal skin, were diminished in leprosy patients when compared with healthy individuals. Twenty-five species were found in leprous skin lesions that were not typical in human skin and considered as potentially pathogenic. The alpha diversity analysis showed that leprous skin lesions is less diverse than that of the healthy skin microbiome.ConclusionAs a conclusion, the skin microbiome on lesional site of leprosy patient show alteration and less diverse compare to healthy individuals. This suggest that leprosy can affects skin microbiome profile or otherwise.

show abstract

Microbiome and the immune system: From a healthy steady-state to allergy associated disruption

Cited by 59 publications

References 135 publications

Emerging Insights on the Interaction Between Anticancer and Immunosuppressant Drugs and Intestinal Microbiota in Pediatric Patients

Emerging Insights on the Interaction Between Anticancer and Immunosuppressant Drugs and Intestinal Microbiota in Pediatric Patients

Linking gut microbiota with human diseases

The First Report of Diversity Analyses of Skin Microbiome In Indonesian Leprosy Patient

Contact Info

Product

Resources

About