Microbiome Contributions to Health

Reynolds, Tyler; Noorbakhsh, Soroosh; Smith, Randi N.

doi:10.1089/sur.2023.002

Cited by 3 publications

(1 citation statement)

References 61 publications

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“…Factors that influence scar formation after burn injury include patient characteristics, such as sex, age, and skin type, and injury and treatment characteristics, such as burn severity, the length of hospitalization, and the type of surgery [5]. These factors also affect the skin microbiome [18][19][20][21][22]. Nevertheless, there is a need to verify which of these factors have a marked influence on the composition of the skin microbiome to gain a better understanding of the skin microbiome in patients with burns.…”

Section: Introductionmentioning

confidence: 99%

Effects of Factors Influencing Scar Formation on the Scar Microbiome in Patients with Burns

Jung,

Cui,

Lee

et al. 2023

IJMS

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Skin microbiome dysbiosis has deleterious effects, and the factors influencing burn scar formation, which affects the scar microbiome composition, are unknown. Therefore, we investigated the effects of various factors influencing scar formation on the scar microbiome composition in patients with burns. We collected samples from the burn scar center and margin of 40 patients with burns, subgrouped by factors influencing scar formation. Scar microbiome composition-influencing factors were analyzed using univariate and multivariate analyses. Skin graft, hospitalization period, intensive care unit (ICU) admission, burn degree, sex, age, total body surface area burned (TBSA), time post-injury, transepidermal water loss, the erythrocyte sedimentation rate, and C-reactive protein levels were identified as factors influencing burn scar microbiome composition. Only TBSA and ICU admission were associated with significant differences in alpha diversity. Alpha diversity significantly decreased with an increase in TBSA and was significantly lower in patients admitted to the ICU than in those not admitted to the ICU. Furthermore, we identified microorganisms associated with various explanatory variables. Our cross-sectional systems biology study confirmed that various variables influence the scar microbiome composition in patients with burns, each of which is associated with various microorganisms. Therefore, these factors should be considered during the application of skin microbiota for burn scar management.

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Section: Introductionmentioning

confidence: 99%

Effects of Factors Influencing Scar Formation on the Scar Microbiome in Patients with Burns

Jung,

Cui,

Lee

et al. 2023

IJMS

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Cardiovascular changes under the microgravity environment and the gut microbiome

Siddiqui,

Qaisar,

Al-Dahash

et al. 2024

Life Sciences in Space Research

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Total body surface area burned and intensive care unit admission greatly influence scar microbiome composition in patients with burns

Jung

Joo

Seo

et al. 2023

Preprint

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Skin microbiome dysbiosis has deleterious effects. Factors influencing pathological burn scar formation, which affects the scar microbiome composition, are unknown. Therefore, we investigated the effects of various factors influencing pathological scar formation on scar microbiome composition in patients with burns. We collected samples from the burn scar center and margin of 40 patients with burns, subgrouped by factors influencing pathological scar formation. Scar microbiome composition-influencing factors were analyzed using univariate and multivariate analyses. Skin graft, hospitalization period, intensive care unit (ICU) admission, burn degree, sex, age, total body surface area burned (TBSA), time post-injury, transepidermal water loss, erythrocyte sedimentation rate, and C-reactive protein levels were factors influencing burn scar microbiome composition. Only TBSA and ICU admission showed significant differences in alpha diversity. Alpha diversity significantly decreased with the increase in TBSA and was significantly lower in patients admitted than in those not admitted to ICU. Furthermore, we identified microorganisms associated with various explanatory variables. Our cross-sectional systems biology study confirmed that various variables influence the scar microbiome composition in patients with burns, each of which is associated with various microorganisms. Therefore, these factors should be considered during application of skin microbiota for burn treatments.

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Microbiome Contributions to Health

Cited by 3 publications

References 61 publications

Effects of Factors Influencing Scar Formation on the Scar Microbiome in Patients with Burns

Effects of Factors Influencing Scar Formation on the Scar Microbiome in Patients with Burns

Cardiovascular changes under the microgravity environment and the gut microbiome

Total body surface area burned and intensive care unit admission greatly influence scar microbiome composition in patients with burns

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