Microbiome Control in the Prevention and Early Management of Cancer

Nguewa, Paul A.; Villa, Tomás G.; Notario, Vicente

doi:10.1007/978-3-319-28368-5_10

Cited by 5 publications

(4 citation statements)

References 98 publications

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“…According to the International Agency on Research for Cancer (IARC), 13–15% of cancer cases are attributable to infectious agents, from which two thirds occurred in less developed countries [ 1 , 2 ]. This causal association has been detected with viruses such as the Epstein–Barr virus, hepatitis B and C viruses, human papilloma virus, human T-cell lymphotropic virus type 1, and also with bacteria like Helicobacter pylori and parasites such as Schistosoma haematobium [ 2 , 3 , 4 ]. Infectious agents are thought to cause pathological alterations including DNA mutations, cell cycle modulation, dysregulation of DNA repair mechanisms, chronic inflammation and immune system impairment, favoring tumorigenesis [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

The BRCT Domain from the Homologue of the Oncogene PES1 in Leishmania major (LmjPES) Promotes Malignancy and Drug Resistance in Mammalian Cells

Larrea

Fernández-Rubio

Peña-Guerrero

et al. 2022

IJMS

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Around 15% of cancer cases are attributable to infectious agents. Epidemiological studies suggest that an association between leishmaniasis and cancer does exist. Recently, the homologue of PES1 in Leishmania major (LmjPES) was described to be involved in parasite infectivity. Mammalian PES1 protein has been implicated in cellular processes like cell cycle regulation. Its BRCT domain has been identified as a key factor in DNA damage-responsive checkpoints. This work aimed to elucidate the hypothetical oncogenic implication of BRCT domain from LmjPES in host cells. We generated a lentivirus carrying this BRCT domain sequence (lentiBRCT) and a lentivirus expressing the luciferase protein (lentiLuc), as control. Then, HEK293T and NIH/3T3 mammalian cells were infected with these lentiviruses. We observed that the expression of BRCT domain from LmjPES conferred to mammal cells in vitro a greater replication rate and higher survival. In in vivo experiments, we observed faster tumor growth in mice inoculated with lentiBRCT respect to lentiLuc HEK293T infected cells. Moreover, the lentiBRCT infected cells were less sensitive to the genotoxic drugs. Accordingly, gene expression profiling analysis revealed that BRCT domain from LmjPES protein altered the expression of proliferation- (DTX3L, CPA4, BHLHE41, BMP2, DHRS2, S100A1 and PARP9), survival- (BMP2 and CARD9) and chemoresistance-related genes (DPYD, Dok3, DTX3L, PARP9 and DHRS2). Altogether, our results reinforced the idea that in eukaryotes, horizontal gene transfer might be also achieved by parasitism like Leishmania infection driving therefore to some crucial biological changes such as proliferation and drug resistance.

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Section: Introductionmentioning

confidence: 99%

The BRCT Domain from the Homologue of the Oncogene PES1 in Leishmania major (LmjPES) Promotes Malignancy and Drug Resistance in Mammalian Cells

Larrea

Fernández-Rubio

Peña-Guerrero

et al. 2022

IJMS

Self Cite

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“…Although smoking is one of the principal causes of cancer development, infections are also a risk factor, mainly those caused by bacteria ( Helicobacter pylori ) (Nguewa et al ., 2016 ) and viruses ( Human papillomavirus , Hepatitis B and C viruses , Herpes virus , Epstein–Bar virus and human T-cell leukaemia-lymphoma virus ) (Liao, 2006 ). However, certain parasitic infections (by Opisthorchis , Clonorchis , Theileria and Schistosoma ) can also raise the risk of developing some types of cancers and may contribute to the appearance of malignancies which makes them possible models to study host–parasite interactions and mechanisms of cancer (De Martel et al ., 2012 ; Tretina et al ., 2015 ; Cheeseman and Weitzman, 2017 ).…”

Section: The Possible Association Of Leishmaniasis and Malignancies (...mentioning

confidence: 99%

Potential therapeutic targets shared between leishmaniasis and cancer

et al. 2021

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“…As the H. pylori infection can spread by contaminated food or water and is transmitted by mouth-to-mouth contact, it is frequently acquired during childhood, and it is estimated to be present in over 60% of the world's population, being particularly frequent in developing countries [87]. Prolonged H. pylori infection ultimately leads to chronic inflammation, a process that dramatically changes the gastric mucosa and stimulates regenerative cell proliferation as well as the production of reactive oxygen species (ROS) and of reactive nitrogen species (RNOS), which together may result in point mutations, deletions and/or translocations in the DNA of the host cells, thereby triggering the onset of the carcinogenic process [88]. The possible association of H. pylori with other types of cancer such as those in the colon [89], lung [90,91] and pancreas [90,92] has also been reported.…”

Section: Bacteria and Cancermentioning

confidence: 99%

A Significant Question in Cancer Risk and Therapy: Are Antibiotics Positive or Negative Effectors? Current Answers and Possible Alternatives

Amadei

Notario

2020

Antibiotics

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Cancer is predominantly considered as an environmental disease caused by genetic or epigenetic alterations induced by exposure to extrinsic (e.g., carcinogens, pollutants, radiation) or intrinsic (e.g., metabolic, immune or genetic deficiencies). Over-exposure to antibiotics, which is favored by unregulated access as well as inappropriate prescriptions by physicians, is known to have led to serious health problems such as the rise of antibiotic resistance, in particular in poorly developed countries. In this review, the attention is focused on evaluating the effects of antibiotic exposure on cancer risk and on the outcome of cancer therapeutic protocols, either directly acting as extrinsic promoters, or indirectly, through interactions with the human gut microbiota. The preponderant evidence derived from information reported over the last 10 years confirms that antibiotic exposure tends to increase cancer risk and, unfortunately, that it reduces the efficacy of various forms of cancer therapy (e.g., chemo-, radio-, and immunotherapy alone or in combination). Alternatives to the current patterns of antibiotic use, such as introducing new antibiotics, bacteriophages or enzybiotics, and implementing dysbiosis-reducing microbiota modulatory strategies in oncology, are discussed. The information is in the end considered from the perspective of the most recent findings on the tumor-specific and intracellular location of the tumor microbiota, and of the most recent theories proposed to explain cancer etiology on the notion of regression of the eukaryotic cells and systems to stages characterized for a lack of coordination among their components of prokaryotic origin, which is promoted by injuries caused by environmental insults.

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Microbiome Control in the Prevention and Early Management of Cancer

Cited by 5 publications

References 98 publications

The BRCT Domain from the Homologue of the Oncogene PES1 in Leishmania major (LmjPES) Promotes Malignancy and Drug Resistance in Mammalian Cells

The BRCT Domain from the Homologue of the Oncogene PES1 in Leishmania major (LmjPES) Promotes Malignancy and Drug Resistance in Mammalian Cells

Potential therapeutic targets shared between leishmaniasis and cancer

A Significant Question in Cancer Risk and Therapy: Are Antibiotics Positive or Negative Effectors? Current Answers and Possible Alternatives

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