Microbiome in cancer: Role in carcinogenesis and impact in therapeutic strategies

Rahman, Md. Mominur; Islam, Md. Rezaul; Shohag, Sheikh; Ahasan, Md. Tanjimul; Sarkar, Nadia; Khan, Hosneara; Hasan, Alexandru Madalin; Cavalu, Simona; Rauf, Abdur

doi:10.1016/j.biopha.2022.112898

Cited by 66 publications

(44 citation statements)

References 225 publications

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“…Despite the diversity of etiology, clinical presentation, and treatment susceptibility, human malignancies share several essential characteristics that deliver promise for the development and enhancement of anti-cancer drugs. The inflammatory response is one such commonality since it has been demonstrated to play a key role in the development of a large variety of cancers ( Diakos et al., 2014 ; Rauf et al., 2021 ; Rahman et al., 2022c ). Mitochondrial dysfunction, increased reactive oxygen species (ROS) production, and the release of damage-associated molecular patterns (DAMPs) have all been linked to human cancer development ( Yang et al., 2016 ; Grazioli and Pugin, 2018 ).…”

Section: Anti-atherosclerotic and Anti-cancer Effects Of The Gut Micr...mentioning

confidence: 99%

The Gut Microbiota (Microbiome) in Cardiovascular Disease and Its Therapeutic Regulation

Rahman

Islam

-Or-Rashid

et al. 2022

Front. Cell. Infect. Microbiol.

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117

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In the last two decades, considerable interest has been shown in understanding the development of the gut microbiota and its internal and external effects on the intestine, as well as the risk factors for cardiovascular diseases (CVDs) such as metabolic syndrome. The intestinal microbiota plays a pivotal role in human health and disease. Recent studies revealed that the gut microbiota can affect the host body. CVDs are a leading cause of morbidity and mortality, and patients favor death over chronic kidney disease. For the function of gut microbiota in the host, molecules have to penetrate the intestinal epithelium or the surface cells of the host. Gut microbiota can utilize trimethylamine, N-oxide, short-chain fatty acids, and primary and secondary bile acid pathways. By affecting these living cells, the gut microbiota can cause heart failure, atherosclerosis, hypertension, myocardial fibrosis, myocardial infarction, and coronary artery disease. Previous studies of the gut microbiota and its relation to stroke pathogenesis and its consequences can provide new therapeutic prospects. This review highlights the interplay between the microbiota and its metabolites and addresses related interventions for the treatment of CVDs.

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Section: Anti-atherosclerotic and Anti-cancer Effects Of The Gut Micr...mentioning

confidence: 99%

The Gut Microbiota (Microbiome) in Cardiovascular Disease and Its Therapeutic Regulation

Rahman

Islam

-Or-Rashid

et al. 2022

Front. Cell. Infect. Microbiol.

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117

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“…The most demotivating aspects for pharma companies to explore natural product-based therapy include the difficult drug development process and validation status, as well as more failure rates in the translational phase. Several issues, such as medication delivery, toxicity, and pharmacokinetics profile, cause almost over 90% of drug research scholars to fail in the clinical translation stage ( Rahman et al, 2022b ). To persuade a pharmaceutical company to begin clinical development trials, significant experimental proof in the preclinical stage is required, bioactive molecules could be isolated through bioassay-guided purification, technique S. et al, 2022).…”

Section: Recent Process and Clinical Applicationsmentioning

confidence: 99%

Fungal Mushrooms: A Natural Compound With Therapeutic Applications

Chugh

Mittal

et al. 2022

Front. Pharmacol.

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Fungi are extremely diverse in terms of morphology, ecology, metabolism, and phylogeny. Approximately, 130 medicinal activities like antitumor, immunomodulation, antioxidant, radical scavenging, cardioprotective and antiviral actions are assumed to be produced by the various varieties of medicinal mushrooms. The polysaccharides, present in mushrooms like β-glucans, micronutrients, antioxidants like glycoproteins, triterpenoids, flavonoids, and ergosterols can help establish natural resistance against infections and toxins.. Clinical trials have been performed on mushrooms like Agaricus blazei Murrill Kyowa for their anticancer effect, A. blazei Murrill for its antihypertensive and cardioprotective effects, and some other mushrooms had also been evaluated for their neurological effects. The human evaluation dose studies had been also performed and the toxicity dose was evaluated from the literature for number of mushrooms. All the mushrooms were found to be safe at a dose of 2000 mg/kg but some with mild side effects. The safety and therapeutic effectiveness of the fungal mushrooms had shifted the interest of biotechnologists toward fungal nanobiotechnology as the drug delivery system due to the vast advantages of nanotechnology systems. In complement to the vital nutritional significance of medicinal mushrooms, numerous species have been identified as sources of bioactive chemicals. Moreover, there are unanswered queries regarding its safety, efficacy, critical issues that affect the future mushroom medicine development, that could jeopardize its usage in the twenty-first century.

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“…The inclusion at epigenetic, genomic, molecular, and cellular levels of several factors influencing the developmental stages of cancer opens up immense opportunities to disrupt and reverse the onset and development of the disorders. It offers various targets for scientists and researchers to avoid cancer growth through physiological and pharmacological mechanisms ( Cragg and Newman, 2005 ; Chopra et al, 2022 ; Rahman et al, 2022g ; Rahman et al, 2022h ; Rahman et al, 2022I ; Rahman et al, 2022J ; Rahman et al, 2022K ; Rauf et al, 2022 ). This article will focus on advances in understanding the signaling pathways of cancer by natural compounds.…”

Section: Introductionmentioning

confidence: 99%

Exploring the recent trends in perturbing the cellular signaling pathways in cancer by natural products

et al. 2022

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Cancer is commonly thought to be the product of irregular cell division. According to the World Health Organization (WHO), cancer is the major cause of death globally. Nature offers an abundant supply of bioactive compounds with high therapeutic efficacy. Anticancer effects have been studied in a variety of phytochemicals found in nature. When Food and Drug Administration (FDA)-approved anticancer drugs are combined with natural compounds, the effectiveness improves. Several agents have already progressed to clinical trials based on these promising results of natural compounds against various cancer forms. Natural compounds prevent cancer cell proliferation, development, and metastasis by inducing cell cycle arrest, activating intrinsic and extrinsic apoptosis pathways, generating reactive oxygen species (ROS), and down-regulating activated signaling pathways. These natural chemicals are known to affect numerous important cellular signaling pathways, such as NF-B, MAPK, Wnt, Notch, Akt, p53, AR, ER, and many others, to cause cell death signals and induce apoptosis in pre-cancerous or cancer cells without harming normal cells. As a result, non-toxic “natural drugs” taken from nature’s bounty could be effective for the prevention of tumor progression and/or therapy of human malignancies, either alone or in combination with conventional treatments. Natural compounds have also been shown in preclinical studies to improve the sensitivity of resistant cancers to currently available chemotherapy agents. To summarize, preclinical and clinical findings against cancer indicate that natural-sourced compounds have promising anticancer efficacy. The vital purpose of these studies is to target cellular signaling pathways in cancer by natural compounds.

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Microbiome in cancer: Role in carcinogenesis and impact in therapeutic strategies

Cited by 66 publications

References 225 publications

The Gut Microbiota (Microbiome) in Cardiovascular Disease and Its Therapeutic Regulation

The Gut Microbiota (Microbiome) in Cardiovascular Disease and Its Therapeutic Regulation

Fungal Mushrooms: A Natural Compound With Therapeutic Applications

Exploring the recent trends in perturbing the cellular signaling pathways in cancer by natural products

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