Microbiota composition modulates inflammation and neointimal hyperplasia after arterial angioplasty

Cason, Cori A.; Kuntz, Thomas; Chen, Edmund B.; Wun, Kelly; Nooromid, Michael J.; Xiong, Liqun; Gottel, Neil; Harris, Katharine G.; Morton, Thomas E.; Avram, Michael J.; Chang, Eugene B.; Gilbert, Jack A.; Ho, Karen J.

doi:10.1016/j.jvs.2019.06.208

Cited by 4 publications

(3 citation statements)

References 59 publications

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“…Notably, in our study, we also speculated that HLA-associated perturbation of the microbiome and metabolite profile might increase the cardiovascular risk in T1D patients. As discussed before, Prevotella copri ( 58 ) and Parabacteroides distasonis ( 59 ) are related to the pathogenesis of CVD. The purine metabolites are associated with CVD risk and mortality in T1D patients ( 60 ).…”

Section: Discussionmentioning

confidence: 93%

High-risk genotypes for type 1 diabetes are associated with the imbalance of gut microbiome and serum metabolites

et al. 2022

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BackgroundThe profile of gut microbiota, serum metabolites, and lipids of type 1 diabetes (T1D) patients with different human leukocyte antigen (HLA) genotypes remains unknown. We aimed to explore gut microbiota, serum metabolites, and lipids signatures in individuals with T1D typed by HLA genotypes.MethodsWe did a cross-sectional study that included 73 T1D adult patients. Patients were categorized into two groups according to the HLA haplotypes they carried: those with any two of three susceptibility haplotypes (DR3, DR4, DR9) and without any of the protective haplotypes (DR8, DR11, DR12, DR15, DR16) were defined as high-risk HLA genotypes group (HR, n=30); those with just one or without susceptibility haplotypes as the non-high-risk HLA genotypes group (NHR, n=43). We characterized the gut microbiome profile with 16S rRNA gene amplicon sequencing and analyzed serum metabolites with liquid chromatography-mass spectrometry.ResultsStudy individuals were 32.5 (8.18) years old, and 60.3% were female. Compared to NHR, the gut microbiota of HR patients were characterized by elevated abundances of Prevotella copri and lowered abundances of Parabacteroides distasonis. Differential serum metabolites (hypoxanthine, inosine, and guanine) which increased in HR were involved in purine metabolism. Different lipids, phosphatidylcholines and phosphatidylethanolamines, decreased in HR group. Notably, Parabacteroides distasonis was negatively associated (p ≤ 0.01) with hypoxanthine involved in purine metabolic pathways.ConclusionsThe present findings enabled a better understanding of the changes in gut microbiome and serum metabolome in T1D patients with HLA risk genotypes. Alterations of the gut microbiota and serum metabolites may provide some information for distinguishing T1D patients with different HLA risk genotypes.

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Section: Discussionmentioning

confidence: 93%

High-risk genotypes for type 1 diabetes are associated with the imbalance of gut microbiome and serum metabolites

et al. 2022

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“…Here, the relative abundance of P. distasonis was inversely correlated to the neointimal hyperplasia and composite intima+media area after a carotid artery angioplasty. 119 Thus, the role of P. distasonis in the pathogenesis of CVD is yet to be determined and remains another point of controversy surrounding this bacterium. It is clear that more research will be needed to determine P. distasonis role in relation to CVD.…”

Section: Diseasesmentioning

confidence: 99%

Parabacteroides distasonis: intriguing aerotolerant gut anaerobe with emerging antimicrobial resistance and pathogenic and probiotic roles in human health

et al. 2021

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Parabacteroides distasonis is the type strain for the genus Parabacteroides, a group of gram-negative anaerobic bacteria that commonly colonize the gastrointestinal tract of numerous species. First isolated in the 1930s from a clinical specimen as Bacteroides distasonis, the strain was re-classified to form the new genus Parabacteroides in 2006. Currently, the genus consists of 15 species, 10 of which are listed as 'validly named' (P. acidifaciens, P. chartae, P. chinchillae, P. chongii, P. distasonis, P. faecis, P. goldsteinii, P. gordonii, P. johnsonii, and P. merdae) and 5 'not validly named' (P. bouchesdurhonensis, P. massiliensis, P. pacaensis, P. provencensis, and P. timonensis) by the List of Prokaryotic names with Standing in Nomenclature. The Parabacteroides genus has been associated with reports of both beneficial and pathogenic effects in human health. Herein, we review the literature on the history, ecology, diseases, antimicrobial resistance, and genetics of this bacterium, illustrating the effects of P. distasonis on human and animal health.

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“…In addition to the above, patients with restenosis also present with changes in their gut microbiota composition and it has been implicated to contribute to its severity [27][28] . A pool of evidence exist reporting the association between gut dysbiosis and the severity of neointimal formation in both animals and humans [29][30][31] . Compared to healthy human controls, alterations in the abundance of Firmicutes and Bacteroidetes were found to be higher and lower respectively in coronary heart disease patients [32] .…”

Section: Food Science and Human Wellnessmentioning

confidence: 99%

Ascophyllum nodosum and Fucus vesiculosus ameliorate restenosis via improving inflammation and regulating the PTEN/PI3K/AKT signaling pathway

Zumbi,

Pan,

Huang

et al. 2024

Food Science and Human Wellness

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Restenosis is a common complication following coronary angioplasty. The traditional use of seaweeds for health benefi ts has increasingly been explored, however few studies exist reporting its protective effects on the development of restenosis and gut dysbiosis. The aim of this study was to investigate the potential of seaweed extracts (SE) of Ascophyllum nodosum and Fucus vesiculosus in inhibiting intimal hyperplasia in a rat model of restenosis and its underlying mechanisms in macrophages and vascular smooth muscle cells (vSMCs). 16S rRNA sequencing was done to investigate the regulatory effect of SE on the gut microbiome of injured rats. As indicated by the results, SE signifi cantly inhibited the progression of intimal hyperplasia in vivo, attenuated inflammation in macrophages and could inhibit the proliferation, dedifferentiation and migration of vSMCs. It was observed through immunoblotting assays that treatment with SE significantly upregulated PTEN expression in macrophages and inhibited the upregulation of PI3K and AKT expression in vSMCs. Meanwhile, according to the 16S rRNA gene sequencing analysis, supplementation with SE modulated gut microbiota composition in injured rats. In conclusion, SE could ameliorate intimal hyperplasia by inhibiting infl ammation and vSMCs proliferation through the regulation of the PTEN/PI3K/AKT pathway and modulating the gut microbiome.

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Microbiota composition modulates inflammation and neointimal hyperplasia after arterial angioplasty

Cited by 4 publications

References 59 publications

High-risk genotypes for type 1 diabetes are associated with the imbalance of gut microbiome and serum metabolites

High-risk genotypes for type 1 diabetes are associated with the imbalance of gut microbiome and serum metabolites

Parabacteroides distasonis: intriguing aerotolerant gut anaerobe with emerging antimicrobial resistance and pathogenic and probiotic roles in human health

Ascophyllum nodosum and Fucus vesiculosus ameliorate restenosis via improving inflammation and regulating the PTEN/PI3K/AKT signaling pathway

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