Microbiota-derived acetate activates intestinal innate immunity via the Tip60 histone acetyltransferase complex

Jugder, Bat-Erdene; Kamareddine, Layla; Watnick, Paula I.

doi:10.1016/j.immuni.2021.05.017

Cited by 53 publications

(38 citation statements)

References 80 publications

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“… 76–78 Acetate, another microbiota-derived SCFA, also inhibited HDAC activity and increased overall acetylation of histones H3 (K9) and H4 (K5/8/16) in CD3/CD28 activated primary human CD4 + T cells, 79 although HDAC inhibition by acetate is somewhat controversial. 18 , 80 , 81 …”

Section: Regulation Of Immune Cells By Scfasmentioning

confidence: 99%

Epigenetic regulation by gut microbiota

2022

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The gastrointestinal tract is continuously exposed to trillions of commensal microbes, collectively termed the microbiota, which are environmental stimuli that can direct health and disease within the host. In addition to well-established bacterial sensing pathways, microbial signals are also integrated through epigenetic modifications that calibrate the transcriptional program of host cells without altering the underlying genetic code. Microbiota-sensitive epigenetic changes include modifications to the DNA or histones, as well as regulation of non-coding RNAs. While microbiota-sensitive epigenetic mechanisms have been described in both local intestinal cells and as well in peripheral tissues, further research is required to fully decipher the complex relationship between the host and microbiota. This Review highlights current understandings of epigenetic regulation by gut microbiota and important implications of these findings in guiding therapeutic approaches to prevent or combat diseases driven by impaired microbiota-host interactions.

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Section: Regulation Of Immune Cells By Scfasmentioning

confidence: 99%

Epigenetic regulation by gut microbiota

2022

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“…Additionally, the acetyl compounds may be converted to deacetyl metabolites and acetate by acetyl esterase from human intestinal microbiome ( Zhou et al, 2020 ). Some recent investigations proved that acetates could contribute to regulation of the host immune system through activation of the immunodeficiency (IMD) pathway ( Jugder et al, 2021 ), and increasing the production of IgA in the colon ( Takeuchi et al, 2021 ). Hence, the transformations of chemical composition from malonates to acetyl compounds during the processing may be related to the enhancement of PAR on the Qi-tonifying effect.…”

Section: Discussionmentioning

confidence: 99%

RRLC-QTOF/MS-Based Metabolomics Reveal the Mechanism of Chemical Variations and Transformations of Astragali Radix as a Result of the Roasting Process

Huang

Sun

et al. 2022

Front. Chem.

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Astragali Radix (AR), which is extensively used as a healthy food supplement and medicinal herb, contains two forms of products corresponding to raw Astragalus Radix (RAR) and processed Astragali Radix (PAR), which was obtained by roasting. In this study, a non-targeted rapid resolution liquid chromatography coupled with quadruple time-of-flight mass spectrometry (RRLC-Q/TOF-MS) based metabolomics approach was developed to investigate the chemical changes of AR due to roasting. A total of 63 compounds were identified or tentatively identified. Among them, 23 isoflavonoids (composed of 12 isoflavones, eight pterocarpans, and three isoflavans) and six cycloastragenols were characterized as differential metabolites. Heatmap visualization and high-performance liquid chromatography coupled with photodiode array and evaporative light scattering detector (HPLC–PDA-ELSD) quantitative analysis revealed that malonyl isoflavonoids or cycloastragenols were at higher levels in RAR. These might be converted to corresponding acetyl isoflavonoids and cycloastragenols and related isoflavonoid glycosides during roasting. To prove this prediction, chemical conversion experiments on malonyl isoflavonoids and cycloastragenols were performed to confirm and clarify the chemical transformation mechanism.

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“…Gut-associated lymphoid tissue (GALT), as part of the host immune system, is involved in the intestinal immune and metabolic responses via fermentation products, such as shortchain fatty acid (SCFA) and acetate, also in the regulation of host mucosal homeostasis, hormones release and vitamin synthesis. Thus, its impact on human health is crucial [88,89]. The power of this ecosystem also supports the fact that the collective genome of gut microbial flora is estimated to contain 100 times more genes than the human genome [90].…”

Section: Gut Microbiotamentioning

confidence: 95%

Where Do We Stand in the Behavioral Pathogenesis of Inflammatory Bowel Disease? The Western Dietary Pattern and Microbiota—A Narrative Review

et al. 2022

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Despite the increasing knowledge with regard to IBD (inflammatory bowel disease), including ulcerative colitis (UC) and Crohn’s disease (CD), the etiology of these conditions is still not fully understood. Apart from immunological, environmental and nutritional factors, which have already been well documented, it is worthwhile to look at the possible impact of genetic factors, as well as the composition of the microbiota in patients suffering from IBD. New technologies in biochemistry allow to obtain information that can add to the current state of knowledge in IBD etiology.

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Microbiota-derived acetate activates intestinal innate immunity via the Tip60 histone acetyltransferase complex

Cited by 53 publications

References 80 publications

Epigenetic regulation by gut microbiota

Epigenetic regulation by gut microbiota

RRLC-QTOF/MS-Based Metabolomics Reveal the Mechanism of Chemical Variations and Transformations of Astragali Radix as a Result of the Roasting Process

Where Do We Stand in the Behavioral Pathogenesis of Inflammatory Bowel Disease? The Western Dietary Pattern and Microbiota—A Narrative Review

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