Microbiota-Gut-Brain Signaling: A Minireview

Kubelková, Klára; Macela, Aleš

doi:10.31482/mmsl.2020.002

Cited by 3 publications

(2 citation statements)

References 95 publications

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“…How can we explain the multiple effects of animal tissue extracts demonstrated in clinical settings? One explanation can be modulation of the microbiota-gut-brain axis (11,12). An alternative explanation can be sought in direct ligations of corresponding receptors by individual components of the extracts after their absorption and general distribution throughout the organism by bodily fluids, whereupon their effects would initiate at the cellular level.…”

Section: Introductionmentioning

confidence: 99%

Molecular Characterization of Alcohol-Ether Extract From Bovine Tissue

Kubelková¹,

Hubálek²,

Řehulka³

et al. 2021

Mil. Med. Sci. Lett.

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It is usual for information to be unavailable regarding the molecular composition of extracts from herbs or animal tissues that are popular in folk medicine. Here, we present analysis of the alcohol-ether extract from bovine tissue analogous to the basic substance used in such commercial products as Retisin, Imuregen, Actovegin, and Solcoseryl. The tested extract contains a whole spectrum of free amino acids, small proteins and oligopeptides of molecular weight up to 10 kDa, various nucleotides, and a small amount of phospholipids. Among the molecules that can explain some biological activities of the extract were identified those of taurine (2-aminoethanesulfonic acid, a derivative of the amino acid cysteine), several defensins, and bactericidal hemoglobin fragments known as hemocidins. All those molecules identified are natural components of bovine tissues, and a substantial number of them might be biologically active in vivo. Others are sources of readily available nutrients.

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Section: Introductionmentioning

confidence: 99%

Molecular Characterization of Alcohol-Ether Extract From Bovine Tissue

Kubelková¹,

Hubálek²,

Řehulka³

et al. 2021

Mil. Med. Sci. Lett.

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“…The consortium of the host and its microbiota together dictates the health status of the metaorganism. The modulatory effect of a mammal's gut microbiome has been documented in relation to the immune system's maturation and its function (2), orchestration of microbiota-gut-brain communication (3)(4)(5), and influencing the origin and therapy of cancers (6,7). Knowledge as to how the microbiota interacts with the host and its constituent species with one another nevertheless remains elusive (8).…”

Section: Introductionmentioning

confidence: 99%

Gut Microbiota Alterations by Nutritional Supplement Imuregen

Kubelková¹,

Rychlı́k²,

Crhánová³

et al. 2020

Mil. Med. Sci. Lett.

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The gut microbiota is one of the modulators influencing its host's development, metabolism, as well as immunological, psychological, and cognitive abilities. The gut microbiota consortium influences enteroendocrine regulation, neurohormonal regulation, as well as natural immune regulation. Disruptions occurring in life can lead to dysbiosis that in turn influences the host homeostasis and/or disease. Targeted modulation of microbiota composition thus appears to be an appropriate intervention strategy in cases of certain specific health problems. Here, we demonstrate that application of the nutritional supplement Imuregen, which is a natural immune booster, modulates the Bacteroidetes/Firmicutes ratio in favor of the Bacteroidetes genera and causes no pathological changes to intestinal epithelium.

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Juvenil, a Natural Immune Booster Affecting Biological Responses Through Modulation Of gut Microbiota Composition

Bostik,

Kubelková,

Macela

2024

MMSL

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Juvenil, a nontoxic extract of bovine blood, is registered as a dietary supplement having no side effects. It contains a broad spectrum of free amino acids, as well as small proteins and oligopeptides (molecular weights up to 10 kDa), various nucleotides, and small amounts of phospholipids. The complex of these exclusively natural components has been shown to support physiological responses of supplemented organisms.Juvenil has been studied for several decades using a wide range of both experimental and clinical studies.Analyses have shown that it acts directly neither on individual functional systems of the body nor on individual metabolic processes. Current findings indicate that modulatory effects of Juvenil occur through modulation of gut microbiota composition, which is associated with the modulation of microbiota-gut-brain axis signaling. In murine model that modulatory effect is reflected in the expression of an early activation c-Fos marker in specific parts of the brain.In this review we present a set of findings about Juvenil, which has a wide range of positive effects on the functional systems of organisms. These effects can be used to strenghten the resistance, immunity, and regeneration of human beings. According to its effects Juvenil can be classified as a psychobiotics.

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Microbiota-Gut-Brain Signaling: A Minireview

Cited by 3 publications

References 95 publications

Molecular Characterization of Alcohol-Ether Extract From Bovine Tissue

Molecular Characterization of Alcohol-Ether Extract From Bovine Tissue

Gut Microbiota Alterations by Nutritional Supplement Imuregen

Juvenil, a Natural Immune Booster Affecting Biological Responses Through Modulation Of gut Microbiota Composition

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