Microbubble-Enhanced Heating: Exploring the Effect of Microbubble Concentration and Pressure Amplitude on High-Intensity Focused Ultrasound Treatments

Clark, Alicia; Bonilla, Sierra; Suo, Dingjie; Shapira, Yeruham; Averkiou, Michalakis A.

doi:10.1016/j.ultrasmedbio.2021.03.035

Cited by 16 publications

(17 citation statements)

References 40 publications

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“…They observed that microbubbles enhanced the heating in phantoms and reduced the power required to form a lesion by about 30% and hypothesized that microbubbles act as nucleation sites that reduce the threshold of inertial cavitation and thus contribute to heating enhancement. Clark et al [20] also observed that the temperature in the tissue would suddenly increase significantly when cavitation bubbles appeared, and they proved that the inertial cavitation of microbubbles was the main reason for the rapid temperature rise. As an ultrasound contrast agent, microbubbles can increase the scattering and reflection of ultrasound in tissue, and they can also increase the absorption loss of ultrasound in tissue so as to increase heat production [40].…”

Section: Discussionmentioning

confidence: 95%

“…Moreover, HIFU treatment may cause serious complications, such as skin burns and liver and abdominal abscesses due to its high energy output [16][17][18]. Cavitation can enhance the efficacy of HIFU through its thermal [19,20], mechanical [21], and chemical effects [22,23]. Therefore, the synergistic effect of cavitation and HIFU is considered to be a promising way to enhance the therapeutic outcomes.…”

Section: Introductionmentioning

confidence: 99%

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Enhanced HIFU Theranostics with Dual-Frequency-Ring Focused Ultrasound and Activatable Perfluoropentane-Loaded Polymer Nanoparticles

et al. 2021

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High-intensity focused ultrasound (HIFU) has been widely used in tumor ablation in clinical settings. Meanwhile, there is great potential to increase the therapeutic efficiency of temporary cavitation due to enhanced thermal effects and combined mechanical effects from nonlinear vibration and collapse of the microbubbles. In this study, dual-frequency (1.1 and 5 MHz) HIFU was used to produce acoustic droplet vaporization (ADV) microbubbles from activatable perfluoropentane-loaded polymer nanoparticles (PFP@Polymer NPs), which increased the therapeutic outcome of the HIFU and helped realize tumor theranostics with ultrasound contrast imaging. Combined with PFP@Polymer NPs, dual-frequency HIFU changed the shape of the damage lesion and reduced the acoustic intensity threshold of thermal damage significantly, from 216.86 to 62.38 W/cm2. It produced a nearly 20 °C temperature increase in half the irradiation time and exhibited a higher tumor inhibition rate (84.5% ± 3.4%) at a low acoustic intensity (1.1 MHz: 23.77 W/cm2; 5 MHz: 0.35 W/cm2) in vitro than the single-frequency HIFU (60.2% ± 11.9%). Moreover, compared with the traditional PFP@BSA NDs, PFP@Polymer NPs showed higher anti-tumor efficacy (81.13% vs. 69.34%; * p < 0.05) and better contrast-enhanced ultrasound (CEUS) imaging ability (gray value of 57.53 vs. 30.67; **** p < 0.0001), probably benefitting from its uniform and stable structure. It showed potential as a highly efficient tumor theranostics approach based on dual-frequency HIFU and activatable PFP@Polymer NPs.

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Enhanced HIFU Theranostics with Dual-Frequency-Ring Focused Ultrasound and Activatable Perfluoropentane-Loaded Polymer Nanoparticles

et al. 2021

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“…To overcome these challenges, various exogenous absorbers such as porphyrin, xanthene, and microbubbles that can enhance the thermal ablation by increasing the attenuation and dissipation of acoustic energy, leading to lower ultrasound power, have been explored [161,167]. More recently, SPIONs have emerged as effective sonosensitizers for focused ultrasound therapy [30].…”

Section: Enhancement Of High-intensity Focused Ultrasound Heatingmentioning

confidence: 99%

Magnetic Nanoparticle-Mediated Heating for Biomedical Applications

Kwizera

Stewart

Mahmud

et al. 2022

Journal of Heat Transfer

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Magnetic nanoparticles, especially superparamagnetic nanoparticles (SPIONs), have attracted tremendous attention for various biomedical applications. Facile synthesis and functionalization together with easy control of the size and shape of SPIONS to customize their unique properties, have made it possible to develop different types of SPIONs tailored for diverse functions/applications. More recently, considerable attention has been paid to the thermal effect of SPIONs for the treatment of diseases like cancer and for nanowarming of cryopreserved/banked cells, tissues, and organs. In this mini-review, recent advances on the magnetic heating effect of SPIONs for magnetothermal therapy and enhancement of cryopreservation of cells, tissues, and organs, are discussed, together with the non-magnetic heating effect (i.e., high Intensity focused ultrasound or HIFU-activated heating) of SPIONs for cancer therapy. Furthermore, challenges facing the use of magnetic nanoparticles in these biomedical applications are presented.

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“…Regardless, the mechanism is thought to be primarily mechanical. Although literature exists on microbubble-enhanced hyperthermia, − it is generally inefficient because the high microbubble concentrations required to cause heating also yield significant pressure attenuation. , …”

Section: Role Of Ultrasound In Modulating Interstitial Fluid Pressure...mentioning

confidence: 99%

“…Although literature exists on microbubble-enhanced hyperthermia, 60−62 it is generally inefficient because the high microbubble concentrations required to cause heating also yield significant pressure attenuation. 62,63 There are few studies evaluating changes in IFP as a result of treatment with FUS and microbubbles, 28,59 which represents a significant opportunity to increase understanding of the interactions between microbubble cavitation and the ECM. However, there is a slightly wider variety of work showing a contradictory reduction in tumor microvascular flow with simultaneous enhanced drug penetration following treatment with FUS, microbubbles, and a systemically delivered drug.…”

Section: ■ Elevated Interstitial Fluid Pressure Within the Tumor Extr...mentioning

confidence: 99%

The Role of Ultrasound in Modulating Interstitial Fluid Pressure in Solid Tumors for Improved Drug Delivery

Keller

Averkiou

2021

Bioconjugate Chem.

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The unique microenvironment of solid tumors, including desmoplasia within the extracellular matrix, enhanced vascular permeability, and poor lymphatic drainage, leads to an elevated interstitial fluid pressure which is a major barrier to drug delivery. Reducing tumor interstitial fluid pressure is one proposed method of increasing drug delivery to the tumor. The goal of this topical review is to describe recent work using focused ultrasound with or without microbubbles to modulate tumor interstitial fluid pressure, through either thermal or mechanical effects on the extracellular matrix and the vasculature. Furthermore, we provide a review on techniques in which ultrasound imaging may be used to diagnose elevated interstitial fluid pressure within solid tumors. Ultrasound-based techniques show high promise in diagnosing and treating elevated interstitial pressure to enhance drug delivery.

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Microbubble-Enhanced Heating: Exploring the Effect of Microbubble Concentration and Pressure Amplitude on High-Intensity Focused Ultrasound Treatments

Cited by 16 publications

References 40 publications

Enhanced HIFU Theranostics with Dual-Frequency-Ring Focused Ultrasound and Activatable Perfluoropentane-Loaded Polymer Nanoparticles

Enhanced HIFU Theranostics with Dual-Frequency-Ring Focused Ultrasound and Activatable Perfluoropentane-Loaded Polymer Nanoparticles

Magnetic Nanoparticle-Mediated Heating for Biomedical Applications

The Role of Ultrasound in Modulating Interstitial Fluid Pressure in Solid Tumors for Improved Drug Delivery

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