Microcalcifications in breast cancer: From pathophysiology to diagnosis and prognosis

O’Grady, Shane; Morgan, Maria P.

doi:10.1016/j.bbcan.2018.04.006

Cited by 109 publications

(85 citation statements)

References 139 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…According to logistic regression analysis, the OR value of coarse calcification and micro-calcification was 0.98 (P=0.9766) and 4.67 (P=0.0006), respectively. Microcalcification was significantly associated with malignant lesions, which is the same as previous studies [28]. In addition, the margins in this study were highly significant for the diagnosis of 4a lesions.…”

Section: Discussionsupporting

confidence: 90%

Risk-predicted dual nomograms consisting of clinical and ultrasound factors for downgrading BI-RADS category 4a breast lesions - A multiple centre study

Niu¹,

Tian²,

Ran³

et al. 2021

J. Cancer

View full text Add to dashboard Cite

Purpose: To develop and to validate a risk-predicted nomogram for downgrading Breast Imaging Reporting and Data System (BI-RADS) category 4a breast lesions. Patients and Methods: We enrolled 680 patients with breast lesions that were diagnosed as BI-RADS category 4a by conventional ultrasound from December 2018 to June 2019. All 4a lesions were randomly divided into development and validation groups at the ratio of 3:1. In the development group consisting of 499 cases, the multiple clinical and ultrasound predicted factors were extracted, and dual-predicted nomograms were constructed by multivariable logistic regression analysis, named clinical nomogram and ultrasound nomogram, respectively. Patients were twice classified as either "high risk" or "low risk" in the two nomograms. The performance of these dual nomograms was assessed by an independent validation group of 181 cases. Receiver Operating Characteristic (ROC) curve and diagnostic value were calculated to evaluate the applicability of the new model. Results: After multiple logistic regression analysis, the clinical nomogram included 2 predictors: age and the first-degree family members with breast cancer. The area under the curve (AUC) value for the clinical nomogram was 0.661 and 0.712 for the development and validation groups, respectively. The ultrasound

show abstract

Section: Discussionsupporting

confidence: 90%

Risk-predicted dual nomograms consisting of clinical and ultrasound factors for downgrading BI-RADS category 4a breast lesions - A multiple centre study

Niu¹,

Tian²,

Ran³

et al. 2021

J. Cancer

View full text Add to dashboard Cite

show abstract

“…The incidence and mortality of breast cancer (BC) have been high among female malignant tumors, which seriously threatens the health of women worldwide (1,2). Despite advances in early screening and therapeutic strategy for BC in recent years, the 5-year survival rate of patients with BC is still not ideal due to high metastases and recurrences (3).…”

Section: Introductionmentioning

confidence: 99%

MiR-3194-3p Inhibits Breast Cancer Progression by Targeting Aquaporin1

Wei

Cai

et al. 2020

Front. Oncol.

View full text Add to dashboard Cite

Increasing evidence indicates that the Aquaporin1 (AQP1) aberrant expression may be related to a wide variety of human cancers, including breast cancer (BC). In the present study, we explore the effects and possible mechanism of miR-3194-3p on the biological behaviors of BC. At first, miR-3194-3p is found to modulate AQP1 expression targeting the 3-UTR using miRNA target prediction algorithms. MiR-3194-3p expression is markedly downregulated, and AQP1 expression is upregulated in BC tissues compared with adjacent normal breast tissues. Moreover, the differential expression of miR-3194-3p and AQP1 are observed in four BC cells with different malignancy degree. Meanwhile, a significant negative correlation between AQP1 and miR-3194-3p expressions in tumor tissues from 30 BC patients is revealed. miR-3194-3p mimic remarkably inhibits cell proliferation, migration, and invasion as well as promotes apoptosis in MDA-MB-231 cells while miR-3194-3p inhibitors exert an opposite role in MCF-7 cells. Dual-luciferase reporter system demonstrates that AQP1 is a direct target gene of miR-3194-3p. Overexpression of AQP1 by pBABE-puro-AQP1 vector partially abrogates the effect of miR-3194-3p mimic in MDA-MB-231 cells. In short, our results suggest that miR-3194-3p suppresses BC cell proliferation, migration, and invasion by targeting AQP1, providing a novel insight into BC tumorigenesis and treatment.

show abstract

“…Moreover, ectopic instigation of epithelium-to-osteomimicry transition in breast cancer cells enhanced bone metastasis in mouse models of breast cancer 57 . Interestingly, primary breast tumors that display micro-calcifications detected by mammographic screening are associated with decreased survival and increased risk of bone metastasis 58 , suggesting that osteomimicry may be a feature of tumor cell subpopulations in the primary tumor that provides them with bone-metastatic advantages. Taken together, our results suggest that acquisition of EMT and osteomimicry programs, combined with instigation of immunosuppression may endow breast cancer cells with bone metastatic capacity.…”

Section: Discussionmentioning

confidence: 99%

Bone metastasis is associated with acquisition of mesenchymal phenotype and immune suppression in a model of spontaneous breast cancer metastasis

Monteran

Ershaid

Sabah

et al. 2020

Sci Rep

View full text Add to dashboard Cite

The most common site of breast cancer metastasis is the bone, occurring in approximately 70% of patients with advanced disease. Bone metastasis is associated with severe morbidities and high mortality. Therefore, deeper understanding of the mechanisms that enable bone-metastatic relapse are urgently needed. We report the establishment and characterization of a bone-seeking variant of breast cancer cells that spontaneously forms aggressive bone metastases following surgical resection of primary tumor. We characterized the modifications in the immune milieu during early and late stages of metastatic relapse and found that the formation of bone metastases is associated with systemic changes, as well as modifications of the bone microenvironment towards an immune suppressive milieu. Furthermore, we characterized the intrinsic changes in breast cancer cells that facilitate bone-tropism and found that they acquire mesenchymal and osteomimetic features. This model provides a clinically relevant platform to study the functional interactions between breast cancer cells and the bone microenvironment, in an effort to identify novel targets for intervention.

show abstract

Microcalcifications in breast cancer: From pathophysiology to diagnosis and prognosis

Cited by 109 publications

References 139 publications

Risk-predicted dual nomograms consisting of clinical and ultrasound factors for downgrading BI-RADS category 4a breast lesions - A multiple centre study

Risk-predicted dual nomograms consisting of clinical and ultrasound factors for downgrading BI-RADS category 4a breast lesions - A multiple centre study

MiR-3194-3p Inhibits Breast Cancer Progression by Targeting Aquaporin1

Bone metastasis is associated with acquisition of mesenchymal phenotype and immune suppression in a model of spontaneous breast cancer metastasis

Contact Info

Product

Resources

About