Microcapsule-gel formulation of promethazine HCl for controlled nasal delivery: A motion sickness medication

McDonough, Joe; Persyn, J T; Niño, Joe A.; Dixon, Hong; Boland, Edward J.; Wang, Z; Putcha, Lakshmi

doi:10.1080/09687860600945628

Cited by 7 publications

(5 citation statements)

References 6 publications

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“…Bioavailability studies require repeated blood sampling. Then, by using an appropriate method, drug estimation is carried out [58].…”

Section: In Vivo Methodsmentioning

confidence: 99%

Mucoadhesive Microspheres: A Promising Tool in Drug Delivery

Patil

Sawant²

2008

CDD

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Mucoadhesive polymers have recently gained interest among pharmaceutical scientists as a means of improving drug delivery by promoting the residence time and contact time of the dosage form with the mucous membranes. Mucoadhesion is the process whereby synthetic and natural polymers adhere to mucosal surfaces in the body. If these materials are then incorporated into pharmaceutical formulations, drug absorption by mucosal cells may be enhanced or the drug will be released at the site for an extended period of time. Microspheres, in general, have the potential to be used for targeted and controlled release drug delivery; however, coupling of mucoadhesive properties to microspheres has additional advantages like, a much more intimate contact with the mucus layer, efficient absorption and enhanced bioavailability of the drugs due to a high surface to volume ratio. The present review describes the potential applications of mucoadhesive microspheres as a novel carrier system to improve drug delivery by various routes of administration like buccal, oral, nasal, ocular, vaginal and rectal, either for systemic or for local effects. The mucoadhesive polymers, methods of preparation of microspheres and their in vitro and in vivo evaluation are also described.

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“…Bioavailability studies require repeated blood sampling. Then, by using an appropriate method, drug estimation is carried out [58].…”

Section: In Vivo Methodsmentioning

confidence: 99%

Mucoadhesive Microspheres: A Promising Tool in Drug Delivery

Patil

Sawant²

2008

CDD

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“…Nanogels are high-viscosity systems containing nanoparticulates (NPs, microcapsules, NEs, etc.) during a compound polymeric network [171]. Nanogels are reassuring and modern drug delivery system that have effective role by sermonizing the drawback associate with old and modern therapeutics like nonspecific effects and poor stability.…”

Section: Nasal Drug Deliverymentioning

confidence: 99%

Overview of nanogel and its applications

Ghaywat¹,

Mate²,

Parsutkar³

et al. 2021

GSC Biol. and Pharm. Sci.

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Nanogel have emerged as a versatile drug delivery system for encapsulation of guest molecules. A nanoparticle which is composed of hydrophilic polymer network known as Nanogel having range from 100-200nm. Nanogel have swellable and degradation properties with high drug loading capacity, high stability, sustained and targetable manner, large surface area. Therefore, nanogel are more productive than conventional and micro-sized delivery. In recent year in the field of biotechnology nanogel were prominently used to deal with genetics, enzyme immobilization and protein synthesis. Moreover, it has productive asset for the development of novel therapeutic system in medicine. These are soft materials capable of holding small molecular biomacromolecules, therapeutics, and inorganic nanoparticles within their crosslinked networks, which allows them to find applications for therapy as well as imaging of a variety of disease conditions. These properties not only enhance the functionality of the carrier system but also help in overcoming many challenges associated with the delivery of cargo molecules. This review aims to highlight the distinct and unique capabilities of nanogels as carrier system, Synthesis of nanogels, Types of Physical and chemical crosslinked nanogels, Stimuli responsive behavior, In vivo behavior, Therapeutic drug carrier, marketed formulation of Nanogels and the last part of review summarizes the applications of nanogels in various diseases. Transdermal drug delivery, diabetes, anti-inflammatory, vaginal drug delivery, neurodegenerative diseases, ocular dieses, autoimmune disease, and anticancer treatment for specially targeting the cancer cells, thereby reducing uptake into healthy cells. This nanogel drug delivery is a phenomenal system, and further depth study is required to explore their interaction at cellular and molecular levels and minimize the challenges.

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“…In another study, microcapsule formulations using palm oil and sorbitan monooleate of PRM were developed [112]. The irritation potential of both microparticulate systems on the nasal epithelial tissue was evaluated in vitro and in vivo, with comparison with pure PRM.…”

Section: Promethazinementioning

confidence: 99%

Nasal route: an alternative approach for antiemetic drug delivery

Özsoy

Güngör

2011

Expert Opinion on Drug Delivery

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Due to its superiorities, the nasal route could be considered as an attractive alternative to oral and parenteral routes. To overcome the barrier properties of the nasal epithelium and to enhance transport of antiemetic drugs, several approaches, including permeation enhancers, in situ gel formulations and micro- and nanoparticulate systems, have been evaluated. The results obtained are promising and indicate that nasal formulations of some antiemetic drugs may enter the market in the near future.

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Microcapsule-gel formulation of promethazine HCl for controlled nasal delivery: A motion sickness medication

Cited by 7 publications

References 6 publications

Mucoadhesive Microspheres: A Promising Tool in Drug Delivery

Mucoadhesive Microspheres: A Promising Tool in Drug Delivery

Overview of nanogel and its applications

Nasal route: an alternative approach for antiemetic drug delivery

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