Microcirculation and blood rheology in patients with cerebrovascular disorders

Тихомирова, И. А.; Oslyakova, Anna O; Михайлова, С. Г.

doi:10.3233/ch-2011-1480

Cited by 72 publications

(45 citation statements)

References 23 publications

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“…9 It is known that, RBC aggregation affects the fluidity of blood in larger blood vessels, where the shear rate is low enough to allow RBC to aggregate. 10,38 The reports on RBC aggregation parameters in patients with glaucoma are very scarce. In patients with normal tension glaucoma, higher aggregation index values were demonstrated, when compared to those of the healthy controls.…”

Section: Discussionmentioning

confidence: 99%

“…Erythrocyte (red blood cell [RBC]) deformability and aggregation, haematocrit, whole blood viscosity (WBV) and plasma viscosity (PV) are the main components of haemorrheology. 9,10 Erythrocyte deformability is ability of the entire cell to change shape under a given level of applied stress without haemolysing, and an increased elongation index (EI) at a given shear stress indicates greater cell deformation. 9 The RBC deformability is of crucial importance for performing its function of oxygen delivery.…”

mentioning

confidence: 99%

“…The physiological importance of erythrocyte aggregation, which is the reversible adhesion of adjacent erythrocytes in circulation, is its tendency to increase blood viscosity at low shear flow and disturb the passage in capillary circulation. 5,9,10 In small vessels, where cells have to deform to pass through, erythrocyte deformability and aggregation are the major determinants of resistance to flow and play an important role in pathogenesis of local ischaemia. [11][12][13][14] Hence, impaired RBC deformability and aggregation may be involved in glaucoma pathogenesis.…”

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confidence: 99%

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Increased erythrocyte aggregation in patients with primary open angle glaucoma

Kilic‐Toprak

Toprak

Kilic-Erkek

et al. 2016

Clinical and Experimental Optometry

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In patients with POAG, erythrocyte aggregation appears to be higher. It can be speculated that higher erythrocyte aggregation and deformability may be involved in the pathogenesis of glaucoma by affecting microperfusion of the optic nerve head and retina. Modification of rheological parameters in patients with glaucoma may be considered as an adjuvant future therapy in glaucoma management, whereas further studies in larger groups are needed.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Increased erythrocyte aggregation in patients with primary open angle glaucoma

Kilic‐Toprak

Toprak

Kilic-Erkek

et al. 2016

Clinical and Experimental Optometry

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“…contort, twist, change shape) when flowing through microvessels ranging in size from 100 μm arterioles down to the smallest 3 μm capillaries. [1-7] Alterations in RBC deformability have been associated with pathophysiological insults in conditions as diverse as diabetes mellitus, sickle cell anemia, malaria, sepsis, and postischaemic reperfusion. [8-14] A reduction in RBC deformability sometimes precedes more severe and often irreversible pathological changes in other vital organs and organ systems, and in some cases may even be the root cause of organ injury.…”

Section: Introductionmentioning

confidence: 99%

The relationship between red blood cell deformability metrics and perfusion of an artificial microvascular network

Sosa

Nielsen

Vignes

et al. 2014

Clinical Hemorheology and Microcirculation

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The ability of red blood cells (RBC) to undergo a wide range of deformations while traversing the microvasculature is crucial for adequate perfusion. Interpretation of RBC deformability measurements performed in vitro in the context of microvascular perfusion has been notoriously difficult. This study compares the measurements of RBC deformability performed using micropore filtration and ektacytometry with the RBC ability to perfuse an artificial microvascular network (AMVN). Human RBCs were collected from healthy consenting volunteers, leukoreduced, washed and exposed to graded concentrations (0% – 0.08%) of glutaraldehyde (a non-specific protein cross-linker) and diamide (a spectrin-specific protein cross-linker) to impair the deformability of RBCs. Samples comprising cells with two different levels of deformability were created by adding non-deformable RBCs (hardened by exposure to 0.08% glutaraldehyde) to the sample of normal healthy RBCs. Ektacytometry indicated a nearly linear decline in RBC deformability with increasing glutaraldehyde concentration. Micropore filtration showed a significant reduction only for concentrations of glutaraldehyde higher than 0.04%. Neither micropore filtration nor ektacytometry measurements could accurately predict the AMVN perfusion. Treatment with diamide reduced RBC deformability as indicated by ektacytometry, but had no significant effect on either micropore filtration or the AMVN perfusion. Both micropore filtration and ektacytometry showed a linear decline in effective RBC deformability with increasing fraction of non-deformable RBCs in the sample. The corresponding decline in the AMVN perfusion plateaued above 50%, reflecting the innate ability of blood flow in the microvasculature to bypass occluded capillaries. Our results suggest that in vitro measurements of RBC deformability performed using either micropore filtration or ektacytometry may not represent the ability of same RBCs to perfuse microvascular networks. Further development of biomimetic tools for measuring RBC deformability (e.g. the AMVN) could enable a more functionally relevant testing of RBC mechanical properties.

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“…In addition, we also found that subjects with greater than or equal to three risk factors had higher levels of HCT than those with one or two risk factors, indicating that the total number of cardiovascular risk factors was positively associated with the level of HCT. Although the exact mechanism of HCT in the association of cardiovascular risk factors is not clear yet, a potential explanation might be that high HCT levels would alter its function as a major determinant of blood viscosity, whose abnormalities may cause the disorders of blood circulation, alter microcirculatory perfusion, increase atherogenesis, promote plaque rupture, and thereby contributing to ischemia (10). In our study, the results also demonstrated that the HCT levels in the ultralow-risk group were significantly lower than in the low-risk, intermediate-risk, and high-risk/ultrahigh-risk groups, revealing that the HCT levels may be an important determinant of CVD risk grade.…”

Section: Discussionmentioning

confidence: 99%