Increased erythrocyte aggregation in patients with primary open angle glaucoma

Kilic‐Toprak, Emine; Toprak, İ̇brahim; Kilic-Erkek, Ozgen; Küçükatay, Vural; Bor-Küçükatay, Melek

doi:10.1111/cxo.12388

Cited by 3 publications

(3 citation statements)

References 30 publications

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“… 36 Kilic-Toprak et al showed that erythrocyte aggregation appears to be higher in patients with POAG. 37 All these are evidence that suggest there might be a pathological basis of hypercoagulability in glaucoma, and provide powerful support for our hypothesis.…”

Section: Discussionsupporting

confidence: 72%

Association between coagulation function and patients with primary angle closure glaucoma: a 5-year retrospective case–control study

Gao

Shao

et al. 2017

BMJ Open

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ObjectiveTo evaluate the association between coagulation function and patients with primary angle closure glaucoma (PACG).DesignA retrospective, hospital-based, case–control study.SettingShanghai, China.ParticipantsA total of 1778 subjects were recruited from the Eye & ENT Hospital of Fudan University from January 2010 to December 2015, including patients with PACG (male=296; female=569) and control subjects (male=290; female=623).Outcome measuresSociodemographic data and clinical data were collected. The one-way analysis of variance test was used to compare the levels of laboratory parameters among the mild, moderate and severe PACG groups. Multivariate logistic regression analyses were performed to identify the independent risk factors for PACG. The nomogram was constructed based on the logistic regression model using the R project for statistical computing (R V.3.3.2).ResultsThe activated partial thromboplastin time (APTT) of the PACG group was approximately 4% shorter (p<0.001) than that of the control group. The prothrombin time (PT) was approximately 2.40% shorter (p<0.001) in patients with PACG compared with the control group. The thrombin time was also approximately 2.14% shorter (p<0.001) in patients with PACG compared with the control group. The level of D-dimer was significantly higher (p=0.042) in patients with PACG. Moreover, the mean platelet volume (MPV) of the PACG group was significantly higher (p=0.013) than that of the control group. A similar trend was observed when coagulation parameters were compared between the PACG and control groups with respect to gender and/or age. Multiple logistic regression analyses revealed that APTT (OR=1.032, 95% CI 1.000 to 1.026), PT (OR=1.249, 95% CI 1.071 to 1.457) and MPV (OR=1.185, 95% CI 1.081 to 1.299) were independently associated with PACG.ConclusionPatients with PACG had a shorter coagulation time. Our results suggest that coagulation function is significantly associated with patients with PACG and may play an important role in the onset and development of PACG.

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Section: Discussionsupporting

confidence: 72%

Association between coagulation function and patients with primary angle closure glaucoma: a 5-year retrospective case–control study

Gao

Shao

et al. 2017

BMJ Open

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“…The pathogenesis of glaucoma has also been linked to alter ocular blood flow [40]. It has been speculated that rheology disorders, such as higher erythrocyte aggregation and deformability, may be involved in the pathogenesis of glaucoma by affecting the microvasculature of the optic nerve head and retina [37]. Similarly, increased MCV and monocyte count may be factors that affect the ocular microcirculation.…”

Section: Discussionmentioning

confidence: 99%

“…Sickle cell anemia has been associated with RNFL thinning as well as elevated IOP in the setting of hyphema [36]. Erythrocyte aggregation was reportedly higher in patients with POAG [37], while RNFL was thinner in severely anemic patients with hematologic malignancies [38]; higher lymphocyte ratio and higher platelet count were associated with faster RNFL thinning [14]. Red cell distribution width was suggested as a useful marker for predicting the presence of pseudoexfoliation syndrome and progression to pseudoexfoliation glaucoma [39].…”

Section: Hematopoietic Featuresmentioning

confidence: 99%

Glaucoma Prediction Models Based on Ocular and Systemic Findings

Landau Prat,

Kapelushnik,

Arazi

et al. 2023

Ophthalmic Res

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Introduction: Our aim was to explore the impact of various systemic and ocular findings on predicting the development of glaucoma. Methods: Medical records of 37,692 consecutive patients examined at a single medical center between 2001-2020 were analyzed using machine learning algorithms. Systemic and ocular features were included. Univariate and multivariate analyses followed by Cat Boost and Light Gradient-Boosting Machine (GBM) prediction models were performed. Main outcome measures were systemic and ocular features associated with progression to glaucoma. Results: 7,880 patients (mean age 54.7±12.6 years, 5520 males [70.1%]) were included in a 3-year prediction model, 314 patients (3.98%) had a final diagnosis of glaucoma. The combined model included 185 systemic and 42 ocular findings, and reached a ROC AUC of 0.84. The associated features were: intraocular pressure (48.6%), cup-to-disc ratio (22.7%), age (8.6%), mean corpuscle volume (MCV) of red blood cells (RBC) trend (5.2%), urinary system disease (3.3%), MCV (2.6%), creatinine level trend (2.1%), monocyte count trend (1.7%), ergometry metabolic equivalent task score (1.7%), dyslipidemia duration (1.6%), prostate-specific antigen level (1.2%), and musculoskeletal disease duration (0.5%). The ocular prediction model reached a ROC AUC of 0.86. Additional features included were: age-related macular degeneration (10.0%), anterior capsular cataract (3.3%), visual acuity (2.0%), and peripapillary atrophy (1.3%). Conclusions: Ocular and combined systemic-ocular models can strongly predict the development of glaucoma in the forthcoming 3 years. Novel progression indicators may include anterior subcapsular cataracts, urinary disorders, and complete blood test results (mainly increased MCV and monocyte count).

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