Microcystic adenoma of the pancreas (glycogen‐rich cystadenoma) with stromal amyloid deposits

Tripodi, Sa; Civitelli, Serenella; Schürfeld, Karin; Cintorino, Marcella

doi:10.1046/j.1365-2559.2000.00939.x

Cited by 12 publications

(5 citation statements)

References 9 publications

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“…Owing to slow growth, the presence of islets within the tumor may be expected 1 . The presence of stromal amyloid deposits was reported in a case of serous microcystic adenoma 14 . Staining for Congo red was negative in the present series and, in one case, studied ultrastructurally, thick collagen bundles were seen in the stroma, but no amyloid fibers were detected.…”

Section: Discussionsupporting

confidence: 41%

“…Thus, we applied keratin expression to a series of cases of serous microcystic adenoma in an attempt to elucidate the cell phenotype of this benign pancreatic cystic neoplasm. The presence of myoepithelial cells 13 and stromal amyloid deposits 14 in serous microcystic adenoma have been reported. In the present study, immunohistochemical expression of hormone receptors, keratins and actin, and the presence of stromal amyloid deposits were examined in 11 cases of serous microcystic adenoma of the pancreas.…”

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confidence: 97%

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Serous microcystic adenoma (glycogen‐rich cystadenoma) of the pancreas: Study of 11 cases showing clinicopathological and immunohistochemical correlations

Yasuhara

Sakaida

Uemura

et al. 2002

Pathology International

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Serous microcystic adenoma of the pancreas, also known as microcystic adenoma, glycogen-rich cystadenoma or serous cystadenoma, is an uncommon benign tumor. We have studied 11 cases involving eight women and three men. The average age at diagnosis was 61.7 years. Four tumors were discovered incidentally. Tumors varied from 1.2 to 20 cm in maximum diameter and all were multicystic. Within the pancreas, three were located in the pancreas head, one involved the head and body, one was located in the body, five were in the tail, and one occupied the whole pancreas. Central stellate scar was seen in five (45%) cases. Histologically, all tumors were composed of microglandular cysts lined by clear epithelial cells rich in glycogen, which were separated by fibrocollagenous stroma. The expression of keratin in clear epithelial cells resembled that in ductal and/or centroacinar cells, but not acinar cells. alpha-Smooth muscle actin (SMA)-positive myoepithelial cells and stromal amyloid deposits were not detected. Ultrastructurally, fibrocollagenous stroma was composed of alpha-SMA-positive myofibroblasts and endothelial cells embedded in thick collagen bundles. Regardless of female propensity, estrogen and progesterone receptors were not detected. Therefore, female predominance in this tumor remains to be elucidated.

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Section: Discussionsupporting

confidence: 41%

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confidence: 97%

Serous microcystic adenoma (glycogen‐rich cystadenoma) of the pancreas: Study of 11 cases showing clinicopathological and immunohistochemical correlations

Yasuhara

Sakaida

Uemura

et al. 2002

Pathology International

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“…There is no cytological atypia, nuclear pleomorphism, necrosis or mitosis. The stroma may be hyalinized and contain entrapped islets, nerve trunks, lymphocytic aggregates or amyloid deposits 18 . There may be irregular extension of the neoplasm into the adjacent pancreas, which shows obstructive/atrophic changes.…”

Section: Serous Cystic Neoplasmsmentioning

confidence: 99%

Cystic neoplasms of the exocrine pancreas

Campbell

Azadeh

2007

Histopathology

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The increasing use of radiological imaging has led to greater detection of small and asymptomatic cystic lesions of the pancreas. Most are resectable, but not all are neoplastic. This review provides an update on the histopathology, immunohistochemistry, molecular biology, pathogenesis and management of cystic neoplasms of the exocrine pancreas. These include the serous, the mucinous cystic, the intraductal papillary mucinous and the solid pseudopapillary neoplasms. Recently reported variants are described and very rare cystic variants of other pancreatic epithelial and mesenchymal neoplasms are briefly mentioned.

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“…Amyloid may also be found in the absence of clinical symptoms. [75], tumors of the skin (e.g., basal cell carcinomas and seborrheic keratosis) [76], cornea, meningiomas [29], pituitary and their adenomas [92], odontogenic tumors [6], medullary cancer of the thyroid, neuroendocine tumors of the lung [1], cardiac atria [101], intima and media of arteries [46,120], mesenteric and portal veins [95], islets of Langerhans [116], microcystic adenoma of the pancreas [113], gastroenteropancreatic endocrine tumors (i.e., insulinomas, vipomas, somatostatinomas) [16,74,119], renal angiomyolipoma [112], pheochromocytomas [107] and seminal vesicles [83]. Local deposits derived from immunoglobulin light chains (AL amyloid) have been found in various organ and tissue sites, often presenting as "amyloidoma".…”

Section: Clinical Featuresmentioning

confidence: 99%

Amyloid in surgical pathology

Röcken

Sletten

2003

Virchows Archiv

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Amyloid is defined as a proteinaceous tissue deposit that shows a typical green birefringence in polarized light after staining with Congo red, the presence of non-branching linear fibrils of indefinite length with a mean diameter of 10 nm, and a distinct X-ray diffraction pattern consistent with Pauling's model of a cross beta-fibril. Amyloid may deposit locally or may present as a systemic disease. The origin of amyloid is diverse: 25 different fibril proteins have been described so far. The precursor proteins differ from each other in their primary structures and functions. The only common denominator is the propensity to form anti-parallel cross beta-fibrils under certain circumstances. Early diagnosis of amyloid is still a major challenge in surgical pathology. Histological proof can be obtained using Congo-red staining and polarization microscopy. However, small deposits may be difficult to discern, and sensitivity can be improved using fluorescence microscopy. Classification of amyloid is mandatory, since amyloid is treatable and different treatment regimens are applied to different amyloid diseases. This review focuses on the epidemiology, clinical features, pathology and diagnosis of amyloid in surgical pathology.

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Microcystic adenoma of the pancreas (glycogen‐rich cystadenoma) with stromal amyloid deposits

Abstract: This is the first documented case of amyloid deposition in pancreatic serous adenoma. We indicate that the source of amyloid is an APP-like precursor secreted by stromal myofibroblasts.

Cited by 12 publications

References 9 publications

Serous microcystic adenoma (glycogen‐rich cystadenoma) of the pancreas: Study of 11 cases showing clinicopathological and immunohistochemical correlations

Serous microcystic adenoma (glycogen‐rich cystadenoma) of the pancreas: Study of 11 cases showing clinicopathological and immunohistochemical correlations

Cystic neoplasms of the exocrine pancreas

Amyloid in surgical pathology

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