Microcystic Adnexal Carcinoma

Burns, Michael K.; Chen, Soo Peen; Goldberg, Leonard Harry

doi:10.1111/j.1524-4725.1994.tb03212.x

Cited by 100 publications

(34 citation statements)

References 28 publications

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“…Although patients usually present with this tumor in the fourth to sixth decade of life, the age range may be much wider, and there are several reports of tumors occurring in children in their second decade of life [10,11,12, 21]. In our study, the mean age at presentation was similar to previous reports.…”

Section: Discussionsupporting

confidence: 80%

“…No recurrence was seen after a 2-month follow-up period. Burns et al [10] described 1 patient with a medial canthal MAC, with no recurrence 6 months after MMS. Another report by Snow et al [13] described a patient with lower lid MAC treated with MMS, with no recurrence after 5 years of follow-up.…”

Section: Discussionmentioning

confidence: 99%

“…There are only a few reports on Mohs’ micrographic surgery (MMS) in the treatment of cutaneous MAC. These reports show more consistently favorable cure rates with a lower recurrence rate of 0–12% [10,11,12,13,14]. …”

Section: Introductionmentioning

confidence: 99%

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Periocular Microcystic Adnexal Carcinoma: Management and Outcome with Mohs’ Micrographic Surgery

et al. 2006

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Purpose: To report a series of patients with periocular microcystic adnexal carcinoma (MAC) treated with Mohs’ micrographic surgery (MMS). Design: Prospective, interventional case series. Methods: This series included all patients treated with MMS for periocular MAC, who were monitored by the Skin and Cancer Foundation Australia between 1993 and 2002. Results: There were 5 patients (4 males, 1 female) with a mean age of 52 ± 12 years. Four tumors were located in the medial canthus and one in the lower lid.The tumor was initially misdiagnosed as basal cell carcinoma in 3 patients and squamous cell carcinoma in 1 patient. The average number of excision levels required for complete removal of the tumor during MMS was 2.2 (range 1–6). Perineural invasion was recorded in one patient.Five-year follow-up data was available for 3 patients, and there was no tumor recurrence in any of these cases. Conclusion: The low 5-year recurrence rate of periocular MAC with MMS emphasizes the importance of margin-controlled excision of this tumor.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

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Periocular Microcystic Adnexal Carcinoma: Management and Outcome with Mohs’ Micrographic Surgery

et al. 2006

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“…It is a slow-growing, locally aggressive, deeply infiltrating tumor that can extend into muscles, fat and bones [8]. Perineural or intraneural involvement is characteristic.…”

Section: Discussionmentioning

confidence: 99%

Microcystic adnexal carcinoma (MAC)-like squamous cell carcinoma as a differential diagnosis to Bell's palsy: Review of guidelines for refractory facial nerve palsy

Müller

Iro

Lell

et al. 2017

Journal of Otolaryngology - Head & Neck Surgery

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BackgroundBell´s palsy is the most common cause of facial paralysis worldwide and the most common disorder of the cranial nerves. It is a diagnosis of exclusion, accounting for 60–75% of all acquired peripheral facial nerve palsies. Our case shows the first case of a microcystic adnexal carcinoma-like squamous cell carcinoma as a cause of facial nerve palsy.Case presentationThe patient, a 70-year-old Caucasian male, experienced subsequent functional impairment of the trigeminal and the glossopharyngeal nerve about 1½ years after refractory facial nerve palsy.An extensive clinical work-up and tissue biopsy of the surrounding parotid gland tissue was not able to determine the cause of the paralysis. Primary infiltration of the facial nerve with subsequent spreading to the trigeminal and glossopharyngeal nerve via neuroanastomoses was suspected. After discussing options with the patient, the main stem of the facial nerve was resected to ascertain the diagnosis of MAC-like squamous cell carcinoma, and radiochemotherapy was subsequently started.ConclusionThis case report shows that even rare neoplastic etiologies should be considered as a cause of refractory facial nerve palsy and that it is necessary to perform an extended diagnostic work-up to ascertain the diagnosis. This includes high-resolution MRI imaging and, as perilesional parotid biopsies might be inadequate for rare cases like ours, consideration of a direct nerve biopsy to establish the right diagnosis.

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“…MAC may have a highly aggressive local course with the ability of direct bone invasion [21], PNI [10, 13, 21, 28, 29] and/or intraneural extension [28, 29]. However, some cases of regional lymph node metastasis have been reported.…”

Section: Discussionmentioning

confidence: 99%

Microcystic Adnexal Carcinoma: Report of Seven Cases Including One with Lung Metastasis

et al. 2006

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Background: Microcystic adnexal carcinoma (MAC) is a rare cutaneous neoplasm, with a high rate of local recurrences. Objective: A series of MAC was analyzed and compared to previously published cases. Methods: Seven cases of MAC were identified in the register of the institution. Medical and pathological records were reviewed. Results: The primary MAC were located on the face in all patients, and 85% were initially misdiagnosed. The mean follow-up duration was 108 months. The recurrence rate was high: 4 patients developed recurrences. In 3 patients, the course of the disease was severe: one of them developed pathologically proven lung metastasis. Conclusion: The present study and review of the literature confirm the clinically aggressive evolution of MAC and its rare ability to give rise to metastasis. Long-term clinical follow-ups with imaging investigations are mandatory.

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Microcystic Adnexal Carcinoma

Abstract: We review the course of 10 patients with microcystic adnexal carcinoma of the face (six primary and four recurrent lesions) and their treatment by Mohs micrographic surgery.

Cited by 100 publications

References 28 publications

Periocular Microcystic Adnexal Carcinoma: Management and Outcome with Mohs’ Micrographic Surgery

Periocular Microcystic Adnexal Carcinoma: Management and Outcome with Mohs’ Micrographic Surgery

Microcystic adnexal carcinoma (MAC)-like squamous cell carcinoma as a differential diagnosis to Bell's palsy: Review of guidelines for refractory facial nerve palsy

Microcystic Adnexal Carcinoma: Report of Seven Cases Including One with Lung Metastasis

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