Microcystin-la from a blue-green alga belonging to the stigonematales

Prinsep, Michèle R.; Caplan, Faith R.; Moore, Richard E.; Patterson, Gregory M. L.; Honkanen, Richard E.; Boynton, Alton L.

doi:10.1016/0031-9422(92)80269-k

Cited by 60 publications

(45 citation statements)

References 14 publications

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“…The production of the most common cyanobacterial toxins, microcystins, is almost exclusively limited to planktonic cyanobacteria (39). The only report of microcystin from a terrestrial cyanobacterium is from Hapalosiphon hibernicus strain BZ-3-1 (34). However, it is not clear if this strain was isolated from a soil sample or a freshwater mud sample (34).…”

mentioning

confidence: 99%

“…The only report of microcystin from a terrestrial cyanobacterium is from Hapalosiphon hibernicus strain BZ-3-1 (34). However, it is not clear if this strain was isolated from a soil sample or a freshwater mud sample (34).…”

mentioning

confidence: 99%

“…A Nostoc rivulare bloom in Texas caused intoxication of wild and domestic animals (8,39). However, despite the screening of cyanobacterial cultures and strains for microcystins and other bioactive compounds during the last decade (34,39), only two strains of the genus Nostoc, Nostoc sp. strain 152 isolated from Lake Sääskjärvi in Finland (40,42) and Nostoc sp.…”

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confidence: 99%

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Discovery of Rare and Highly Toxic Microcystins from Lichen-Associated Cyanobacterium Nostoc sp. Strain IO-102-I

Oksanen¹,

Jokela²,

Fewer³

et al. 2004

Appl Environ Microbiol

140

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The production of hepatotoxic cyclic heptapeptides, microcystins, is almost exclusively reported from planktonic cyanobacteria. Here we show that a terrestrial cyanobacterium Nostoc sp. strain IO-102-I isolated from a lichen association produces six different microcystins. Microcystins were identified with liquid chromatography-UV mass spectrometry by their retention times, UV spectra, mass fragmentation, and comparison to microcystins from the aquatic Nostoc sp. strain 152.

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Discovery of Rare and Highly Toxic Microcystins from Lichen-Associated Cyanobacterium Nostoc sp. Strain IO-102-I

Oksanen¹,

Jokela²,

Fewer³

et al. 2004

Appl Environ Microbiol

140

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“…In this sense, the ability of C. raciborskii to tolerate wide variations in nutrient availability and fix atmospheric nitrogen is well documented (Isvánovics et al 2000;Moisander et al 2012), as well the high ammonium and nitrate uptake affinity (Présing et al 1996). Literature review shows that C. raciborskii can present physiological trade-offs in abilities to acquire and utilize resources, especially the advantage over bacteria and/ or other phytoplankton to quickly assimilate P (Currie & Kalf 1984;Prinsep et al 2001;Marinho et al 2013), being considered an opportunistic species in its P-storage capacity (Isvánovics et al 2000). Due to this ecophysiology flexibility there is evidence that C. raciborskii from several parts of the world have different genotypes (Dyble et al 2002;Fathalli et al 2011) and ecotypes that are able to growth in lakes of different trophic status (Piccini et al 2011).…”

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Considerations regarding the dominance of Cylindrospermopsis raciborskii under low light availability in a low phosphorus lake

et al. 2015

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Although many studies have shown that the dispersion, increased abundance and dominance of cyanobacteria can be attributed to nutrient enrichment, we discuss features contributing to the dominance of Cylindrospermopsis raciborskii in a shallow, polymictic, subtropical coastal lake with low phosphorus and light limitation (Peri Lake). The presence and dominance of C. raciborskii in an environment with such characteristics emphasizes the idea that nutrients alone do not explain the high density of this cyanobacterium. Other features should be considered in explaining this species dominance, such as phosphorus storage and physiological flexibility, which seem to be key features to high densities in low phosphorus systems.

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“…Over sixty have been isolated and fully characterised from Microcystis, Anabaena, Oscillatoria, and Nostoc genera, as well as being found in terrestrial forms (Hapalosiphon hibernicus) (Prinsep et al, 1992). Microcystins are absorbed across the ileum and uptaken via the bile transport system; they are taken up by hepatocytes and bind covalently to protein phosphatase 1 and 2A.…”

Section: Introductionmentioning

confidence: 99%

Investigation of the toxicology and public health aspects of the marine cyanobacterium, Lyngbya majuscula

Osborne¹

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Lyngbya majuscula is a filamentous marine cyanobacterium with a worldwide distribution in temperate and tropical regions to a depth of 30m. Over 70 chemicals have been isolated and characterised from this organism, many of which are biologically active. Dramatic responses have been elicited after human exposure to lyngbyatoxin A (LA) and debromoaplysiatoxin (DAT), toxins extracted from L. majuscula. These chemicals have been found to cause irritation at concentrations as low as 100 pmol and exposure of humans to this cyanobacterium in the enviroimient is associated with irritant contact dermatitis, as well as eye and respiratory irritation. In an effort to understand the potential exposure of humans to the toxins of Z. majuscula the spatial and temporal distribution of LA and DAT were made in Eastern Moreton Bay and Northern Deception Bay. Not all samples of L. majuscula contained LA or DAT. More than ten-fold differences in DAT concentration were found at a single time at North Deception Bay (0.93-11.17 mg/kg freeze dry weight).LA was predominantly found at Eastem Moreton Bay while DAT was found only at North Deception Bay. Highest concentrations of toxin occurred when bloom size and density were also at their maximum (131.9 mg/kg LA and 43.0 mg/kg DAT). In an attempt to predict where L. majuscula biomass and toxins were maximal, and hence greatest chance of human exposure, a variety of physical and biotic parameters were obtained. Bloom intensity occurred when water temperature was maximal. Low precipitation periods were noted to occur before blooms. Total and dissolved reactive phosphorus were present at bloom initiation and peaks of chlorophyll-a in the water column were found at the peaks of Z,. majuscula bloom intensity.In an attempt to understand the extent of human exposure to the toxic effects of L. majuscula several epidemiological studies were completed. To assess the potential affects a survey of the health of ocean users in the North Deception Bay area, a residential area close to L. majuscula blooms, was undertaken. A postal survey was mailed to 5000 residents and a response rate of 27.4% was achieved.High numbers of people (78.2%) responding to the survey reported marine recreational water activity in Moreton Bay. Of those having marine recreational water activity, 34.6% reported at least one symptom, with skin itching the most reported symptom (22.7%) while fever was the least (0.4%). Younger participants had greater water exposure and symptoms than older participants. Participants with greater exposures were more likely to have skin and eye symptoms, suggesting agents in the marine enviroimient contributing to symptoms. Of those entering Moreton Bay waters 29 (2.7%) reported severe skin symptoms, 12 of who attended health professionals. Six (0.6%) reported the classic symptoms of recreational water exposure to L. majuscula, severe skin symptoms in the inguinal region. Participants with knowledge of L. majuscula reported less skin, gastrointestinal and fever and headache symptoms.

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Microcystin-la from a blue-green alga belonging to the stigonematales

Cited by 60 publications

References 14 publications

Discovery of Rare and Highly Toxic Microcystins from Lichen-Associated Cyanobacterium Nostoc sp. Strain IO-102-I

Discovery of Rare and Highly Toxic Microcystins from Lichen-Associated Cyanobacterium Nostoc sp. Strain IO-102-I

Considerations regarding the dominance of Cylindrospermopsis raciborskii under low light availability in a low phosphorus lake

Investigation of the toxicology and public health aspects of the marine cyanobacterium, Lyngbya majuscula

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